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Entry version 177 (12 Aug 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Cdc42 effector protein 1

Gene

CDC42EP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q00587

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q00587

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cdc42 effector protein 1
Alternative name(s):
Binder of Rho GTPases 5
Serum protein MSE55
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDC42EP1
Synonyms:BORG5, CEP1, MSE55
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000128283.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17014, CDC42EP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606084, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q00587

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi36 – 47DMISH…GDFRH → AMISHALGDFRA: No binding with CDC42. 1 PublicationAdd BLAST12

Organism-specific databases

DisGeNET

More...
DisGeNETi
11135

Open Targets

More...
OpenTargetsi
ENSG00000128283

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38430

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q00587, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDC42EP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
462623

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002126571 – 391Cdc42 effector protein 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei34PhosphothreonineBy similarity1
Modified residuei39PhosphoserineBy similarity1
Modified residuei53Omega-N-methylarginineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei139PhosphoserineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei303PhosphoserineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q00587

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q00587

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q00587

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q00587

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q00587

PeptideAtlas

More...
PeptideAtlasi
Q00587

PRoteomics IDEntifications database

More...
PRIDEi
Q00587

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57858 [Q00587-1]
57859 [Q00587-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q00587

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q00587

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Endothelial and bone marrow stromal cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128283, Expressed in fundus of stomach and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q00587, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q00587, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000128283, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116308, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q00587, 35 interactors

Molecular INTeraction database

More...
MINTi
Q00587

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000249014

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q00587, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q00587

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 52CRIBPROSITE-ProRule annotationAdd BLAST15
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati220 – 22617
Repeati227 – 23327
Repeati234 – 24037
Repeati241 – 24747
Repeati248 – 25457
Repeati255 – 26167
Repeati262 – 26877
Repeati269 – 27587

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni220 – 2758 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]Add BLAST56

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CRIB domain mediates interaction with CDC42.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RZ2H, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160068

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_787446_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00587

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLNQATY

Database of Orthologous Groups

More...
OrthoDBi
1244464at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q00587

TreeFam database of animal gene trees

More...
TreeFami
TF331725

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029273, Cdc42_effect
IPR000095, CRIB_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14957, BORG_CEP, 1 hit
PF00786, PBD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00285, PBD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50108, CRIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGPQGGRGA ATMSLGKLSP VGWVSSSQGK RRLTADMISH PLGDFRHTMH
60 70 80 90 100
VGRGGDVFGD TSFLSNHGGS SGSTHRSPRS FLAKKLQLVR RVGAPPRRMA
110 120 130 140 150
SPPAPSPAPP AISPIIKNAI SLPQLNQAAY DSLVVGKLSF DSSPTSSTDG
160 170 180 190 200
HSSYGLDSGF CTISRLPRSE KPHDRDRDGS FPSEPGLRRS DSLLSFRLDL
210 220 230 240 250
DLGPSLLSEL LGVMSLPEAP AAETPAPAAN PPAPTANPTG PAANPPATTA
260 270 280 290 300
NPPAPAANPS APAATPTGPA ANPPAPAASS TPHGHCPNGV TAGLGPVAEV
310 320 330 340 350
KSSPVGGGPR GPAGPALGRH WGAGWDGGHH YPEMDARQER VEVLPQARAS
360 370 380 390
WESLDEEWRA PQAGSRTPVP STVQANTFEF ADAEEDDEVK V
Length:391
Mass (Da):40,295
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i625EA3C71F20CF2B
GO
Isoform 2 (identifier: Q00587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-264: Missing.

Show »
Length:384
Mass (Da):39,686
Checksum:i3D056D62399AE422
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYC6B0QYC6_HUMAN
Cdc42 effector protein 1
CDC42EP1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYC7B0QYC7_HUMAN
Cdc42 effector protein 1
CDC42EP1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYC8B0QYC8_HUMAN
Cdc42 effector protein 1
CDC42EP1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004325258 – 264Missing in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M88338 mRNA Translation: AAA36606.1
CR456524 mRNA Translation: CAG30410.1
AK292190 mRNA Translation: BAF84879.1
AL022315 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60164.1
BC009356 mRNA Translation: AAH09356.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13949.1 [Q00587-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A42973

NCBI Reference Sequences

More...
RefSeqi
NP_689449.1, NM_152243.2 [Q00587-1]
XP_006724170.1, XM_006724107.1
XP_006724171.1, XM_006724108.1
XP_006724172.1, XM_006724109.1
XP_016884030.1, XM_017028541.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000249014; ENSP00000249014; ENSG00000128283 [Q00587-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11135

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11135

UCSC genome browser

More...
UCSCi
uc003asz.5, human [Q00587-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88338 mRNA Translation: AAA36606.1
CR456524 mRNA Translation: CAG30410.1
AK292190 mRNA Translation: BAF84879.1
AL022315 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60164.1
BC009356 mRNA Translation: AAH09356.1
CCDSiCCDS13949.1 [Q00587-1]
PIRiA42973
RefSeqiNP_689449.1, NM_152243.2 [Q00587-1]
XP_006724170.1, XM_006724107.1
XP_006724171.1, XM_006724108.1
XP_006724172.1, XM_006724109.1
XP_016884030.1, XM_017028541.1

3D structure databases

SMRiQ00587
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116308, 26 interactors
IntActiQ00587, 35 interactors
MINTiQ00587
STRINGi9606.ENSP00000249014

PTM databases

iPTMnetiQ00587
PhosphoSitePlusiQ00587

Polymorphism and mutation databases

BioMutaiCDC42EP1
DMDMi462623

Proteomic databases

EPDiQ00587
jPOSTiQ00587
MassIVEiQ00587
MaxQBiQ00587
PaxDbiQ00587
PeptideAtlasiQ00587
PRIDEiQ00587
ProteomicsDBi57858 [Q00587-1]
57859 [Q00587-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
299, 127 antibodies

The DNASU plasmid repository

More...
DNASUi
11135

Genome annotation databases

EnsembliENST00000249014; ENSP00000249014; ENSG00000128283 [Q00587-1]
GeneIDi11135
KEGGihsa:11135
UCSCiuc003asz.5, human [Q00587-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11135
DisGeNETi11135
EuPathDBiHostDB:ENSG00000128283.6

GeneCards: human genes, protein and diseases

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GeneCardsi
CDC42EP1
HGNCiHGNC:17014, CDC42EP1
HPAiENSG00000128283, Low tissue specificity
MIMi606084, gene
neXtProtiNX_Q00587
OpenTargetsiENSG00000128283
PharmGKBiPA38430

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502RZ2H, Eukaryota
GeneTreeiENSGT00940000160068
HOGENOMiCLU_787446_0_0_1
InParanoidiQ00587
OMAiQLNQATY
OrthoDBi1244464at2759
PhylomeDBiQ00587
TreeFamiTF331725

Enzyme and pathway databases

PathwayCommonsiQ00587
SignaLinkiQ00587

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
11135, 4 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CDC42EP1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CDC42EP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11135
PharosiQ00587, Tbio

Protein Ontology

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PROi
PR:Q00587
RNActiQ00587, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000128283, Expressed in fundus of stomach and 208 other tissues
ExpressionAtlasiQ00587, baseline and differential
GenevisibleiQ00587, HS

Family and domain databases

InterProiView protein in InterPro
IPR029273, Cdc42_effect
IPR000095, CRIB_dom
PfamiView protein in Pfam
PF14957, BORG_CEP, 1 hit
PF00786, PBD, 1 hit
SMARTiView protein in SMART
SM00285, PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108, CRIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBORG5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00587
Secondary accession number(s): A8K825, Q96GN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 12, 2020
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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