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Protein

GTP-binding protein GTR1

Gene

GTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Functionally associated with the inorganic phosphate transporter PHO84. It is probably required for modulation of PHO84 or involved in its intracellular localization.

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPSequence analysis8
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

  • cellular response to amino acid stimulus Source: GO_Central
  • cellular response to starvation Source: GO_Central
  • chromatin silencing at telomere Source: SGD
  • negative regulation of autophagy Source: SGD
  • phosphate ion transport Source: SGD
  • positive regulation of TORC1 signaling Source: SGD
  • protein localization to vacuolar membrane Source: SGD
  • protein transport Source: UniProtKB-KW
  • transcription by RNA polymerase I Source: SGD
  • transcription by RNA polymerase III Source: SGD

Keywordsi

Biological processPhosphate transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32701-MONOMER
ReactomeiR-SCE-165159 mTOR signalling

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein GTR1
Gene namesi
Name:GTR1
Ordered Locus Names:YML121W
ORF Names:YM7056.05
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML121W
SGDiS000004590 GTR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224861 – 310GTP-binding protein GTR1Add BLAST310

Proteomic databases

MaxQBiQ00582
PaxDbiQ00582
PRIDEiQ00582

Interactioni

Subunit structurei

Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi35083, 402 interactors
ComplexPortaliCPX-3172 EGO complex
CPX-3233 GSE complex
DIPiDIP-1358N
IntActiQ00582, 21 interactors
MINTiQ00582
STRINGi4932.YML121W

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi19 – 27Combined sources9
Helixi33 – 37Combined sources5
Beta strandi43 – 51Combined sources9
Turni52 – 54Combined sources3
Beta strandi55 – 62Combined sources8
Helixi66 – 73Combined sources8
Turni74 – 76Combined sources3
Helixi77 – 81Combined sources5
Beta strandi85 – 92Combined sources8
Helixi98 – 115Combined sources18
Beta strandi120 – 126Combined sources7
Helixi128 – 130Combined sources3
Helixi133 – 152Combined sources20
Turni153 – 155Combined sources3
Beta strandi160 – 163Combined sources4
Helixi170 – 180Combined sources11
Helixi186 – 200Combined sources15
Beta strandi202 – 209Combined sources8
Turni210 – 212Combined sources3
Beta strandi215 – 218Combined sources4
Helixi242 – 257Combined sources16
Helixi258 – 260Combined sources3
Beta strandi264 – 269Combined sources6
Turni270 – 272Combined sources3
Beta strandi273 – 279Combined sources7
Beta strandi282 – 289Combined sources8
Helixi295 – 301Combined sources7
Turni302 – 305Combined sources4

3D structure databases

ProteinModelPortaliQ00582
SMRiQ00582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTR/RAG GTP-binding protein family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074769
HOGENOMiHOG000173258
InParanoidiQ00582
KOiK16185
OMAiSNYIARD
OrthoDBiEOG092C4MSK

Family and domain databases

InterProiView protein in InterPro
IPR006762 Gtr1_RagA
IPR027417 P-loop_NTPase
PANTHERiPTHR11259 PTHR11259, 1 hit
PfamiView protein in Pfam
PF04670 Gtr1_RagA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q00582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNNRKKLL LMGRSGSGKS SMRSIIFSNY SAFDTRRLGA TIDVEHSHLR
60 70 80 90 100
FLGNMTLNLW DCGGQDVFME NYFTKQKDHI FQMVQVLIHV FDVESTEVLK
110 120 130 140 150
DIEIFAKALK QLRKYSPDAK IFVLLHKMDL VQLDKREELF QIMMKNLSET
160 170 180 190 200
SSEFGFPNLI GFPTSIWDES LYKAWSQIVC SLIPNMSNHQ SNLKKFKEIM
210 220 230 240 250
NALEIILFER TTFLVICSSN GENSNENHDS SDNNNVLLDP KRFEKISNIM
260 270 280 290 300
KNFKQSCTKL KSGFKTLILN NNIYVSELSS NMVCFIVLKD MNIPQELVLE
310
NIKKAKEFFQ
Length:310
Mass (Da):35,847
Last modified:October 1, 1993 - v1
Checksum:iB79CE7FE7AD2FDBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10018 Genomic DNA Translation: BAA00907.1
Z49218 Genomic DNA Translation: CAA89159.1
AY692917 Genomic DNA Translation: AAT92936.1
BK006946 Genomic DNA Translation: DAA09777.1
PIRiS31303
RefSeqiNP_013585.1, NM_001182484.1

Genome annotation databases

EnsemblFungiiYML121W; YML121W; YML121W
GeneIDi854918
KEGGisce:YML121W

Similar proteinsi

Entry informationi

Entry nameiGTR1_YEAST
AccessioniPrimary (citable) accession number: Q00582
Secondary accession number(s): D6W0G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 18, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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