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Protein

Transcriptional activator protein Pur-alpha

Gene

PURA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q00577

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q00577

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional activator protein Pur-alpha
Alternative name(s):
Purine-rich single-stranded DNA-binding protein alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PURA
Synonyms:PUR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185129.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9701 PURA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600473 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q00577

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 31 (MRD31)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD31 patients manifest neonatal hypotonia, encephalopathy with or without epilepsy, and severe developmental delay.
See also OMIM:616158
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07269888 – 89IA → T in MRD31. 1 Publication2
Natural variantiVAR_07269989A → P in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587782999EnsemblClinVar.1
Natural variantiVAR_07270097K → E in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587782994EnsemblClinVar.1
Natural variantiVAR_072701100L → P in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587782995EnsemblClinVar.1
Natural variantiVAR_072702157M → K in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587782998EnsemblClinVar.1
Natural variantiVAR_072703199R → P in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587783001EnsemblClinVar.1
Natural variantiVAR_073993206I → F in MRD31. 1 PublicationCorresponds to variant dbSNP:rs786204834EnsemblClinVar.1
Natural variantiVAR_073994233Missing in MRD31. 1 Publication1
Natural variantiVAR_072704271Missing in MRD31. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5813

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PURA

MalaCards human disease database

More...
MalaCardsi
PURA
MIMi616158 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000185129

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
438216 PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome due to a point mutation
314655 Severe neonatal hypotonia-seizures-encephalopathy syndrome due to 5q31.3 microdeletion

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34045

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PURA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1346918

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971072 – 322Transcriptional activator protein Pur-alphaAdd BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei182PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q00577

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q00577

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q00577

PeptideAtlas

More...
PeptideAtlasi
Q00577

PRoteomics IDEntifications database

More...
PRIDEi
Q00577

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57857

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q00577

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q00577

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q00577

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185129 Expressed in 243 organ(s), highest expression level in substantia nigra

CleanEx database of gene expression profiles

More...
CleanExi
HS_PURA

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q00577 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, heterodimer with PURB and heterotrimer with PURB and YBX1/Y-box protein 1. Interacts with FMR1; this interaction occurs in association with polyribosome.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111772, 87 interactors

Protein interaction database and analysis system

More...
IntActi
Q00577, 18 interactors

Molecular INTeraction database

More...
MINTi
Q00577

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332706

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q00577

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q00577

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 53Gly-richAdd BLAST43
Compositional biasi293 – 322Gln/Glu-rich (part of the transcriptional activation domain)Add BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PUR DNA-binding protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3074 Eukaryota
ENOG410ZKKR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161749

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232132

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006888

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00577

KEGG Orthology (KO)

More...
KOi
K21772

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPYKVWS

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0JS7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q00577

TreeFam database of animal gene trees

More...
TreeFami
TF313701

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006628 PUR-bd_fam
IPR030500 PURalpha

The PANTHER Classification System

More...
PANTHERi
PTHR12611 PTHR12611, 1 hit
PTHR12611:SF2 PTHR12611:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04845 PurA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00712 PUR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q00577-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADRDSGSEQ GGAALGSGGS LGHPGSGSGS GGGGGGGGGG GGSGGGGGGA
60 70 80 90 100
PGGLQHETQE LASKRVDIQN KRFYLDVKQN AKGRFLKIAE VGAGGNKSRL
110 120 130 140 150
TLSMSVAVEF RDYLGDFIEH YAQLGPSQPP DLAQAQDEPR RALKSEFLVR
160 170 180 190 200
ENRKYYMDLK ENQRGRFLRI RQTVNRGPGL GSTQGQTIAL PAQGLIEFRD
210 220 230 240 250
ALAKLIDDYG VEEEPAELPE GTSLTVDNKR FFFDVGSNKY GVFMRVSEVK
260 270 280 290 300
PTYRNSITVP YKVWAKFGHT FCKYSEEMKK IQEKQREKRA ACEQLHQQQQ
310 320
QQQEETAAAT LLLQGEEEGE ED
Length:322
Mass (Da):34,911
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i797968504D01B356
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07269888 – 89IA → T in MRD31. 1 Publication2
Natural variantiVAR_07269989A → P in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587782999EnsemblClinVar.1
Natural variantiVAR_07270097K → E in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587782994EnsemblClinVar.1
Natural variantiVAR_072701100L → P in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587782995EnsemblClinVar.1
Natural variantiVAR_072702157M → K in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587782998EnsemblClinVar.1
Natural variantiVAR_072703199R → P in MRD31. 1 PublicationCorresponds to variant dbSNP:rs587783001EnsemblClinVar.1
Natural variantiVAR_073993206I → F in MRD31. 1 PublicationCorresponds to variant dbSNP:rs786204834EnsemblClinVar.1
Natural variantiVAR_073994233Missing in MRD31. 1 Publication1
Natural variantiVAR_072704271Missing in MRD31. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M96684 mRNA Translation: AAA60229.1
U02098 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4220.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45036

NCBI Reference Sequences

More...
RefSeqi
NP_005850.1, NM_005859.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.443121
Hs.733524

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331327; ENSP00000332706; ENSG00000185129

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5813

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5813

UCSC genome browser

More...
UCSCi
uc003lfa.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96684 mRNA Translation: AAA60229.1
U02098 mRNA No translation available.
CCDSiCCDS4220.1
PIRiA45036
RefSeqiNP_005850.1, NM_005859.4
UniGeneiHs.443121
Hs.733524

3D structure databases

ProteinModelPortaliQ00577
SMRiQ00577
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111772, 87 interactors
IntActiQ00577, 18 interactors
MINTiQ00577
STRINGi9606.ENSP00000332706

PTM databases

iPTMnetiQ00577
PhosphoSitePlusiQ00577
SwissPalmiQ00577

Polymorphism and mutation databases

BioMutaiPURA
DMDMi1346918

Proteomic databases

EPDiQ00577
MaxQBiQ00577
PaxDbiQ00577
PeptideAtlasiQ00577
PRIDEiQ00577
ProteomicsDBi57857

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331327; ENSP00000332706; ENSG00000185129
GeneIDi5813
KEGGihsa:5813
UCSCiuc003lfa.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5813
DisGeNETi5813
EuPathDBiHostDB:ENSG00000185129.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PURA
GeneReviewsiPURA
HGNCiHGNC:9701 PURA
MalaCardsiPURA
MIMi600473 gene
616158 phenotype
neXtProtiNX_Q00577
OpenTargetsiENSG00000185129
Orphaneti438216 PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome due to a point mutation
314655 Severe neonatal hypotonia-seizures-encephalopathy syndrome due to 5q31.3 microdeletion
PharmGKBiPA34045

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3074 Eukaryota
ENOG410ZKKR LUCA
GeneTreeiENSGT00940000161749
HOGENOMiHOG000232132
HOVERGENiHBG006888
InParanoidiQ00577
KOiK21772
OMAiVPYKVWS
OrthoDBiEOG091G0JS7
PhylomeDBiQ00577
TreeFamiTF313701

Enzyme and pathway databases

SignaLinkiQ00577
SIGNORiQ00577

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PURA human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PURA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5813

Protein Ontology

More...
PROi
PR:Q00577

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185129 Expressed in 243 organ(s), highest expression level in substantia nigra
CleanExiHS_PURA
GenevisibleiQ00577 HS

Family and domain databases

InterProiView protein in InterPro
IPR006628 PUR-bd_fam
IPR030500 PURalpha
PANTHERiPTHR12611 PTHR12611, 1 hit
PTHR12611:SF2 PTHR12611:SF2, 1 hit
PfamiView protein in Pfam
PF04845 PurA, 1 hit
SMARTiView protein in SMART
SM00712 PUR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPURA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00577
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: December 5, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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