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Protein

Cyclin-dependent kinase 17

Gene

CDK17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei221ATPPROSITE-ProRule annotation1
Active sitei313Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 206ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
SignaLinkiQ00537

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 17 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 17
PCTAIRE-motif protein kinase 2
Serine/threonine-protein kinase PCTAIRE-2
Gene namesi
Name:CDK17
Synonyms:PCTAIRE2, PCTK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000059758.7
HGNCiHGNC:8750 CDK17
MIMi603440 gene
neXtProtiNX_Q00537

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5128
OpenTargetsiENSG00000059758
PharmGKBiPA33096

Chemistry databases

ChEMBLiCHEMBL5790

Polymorphism and mutation databases

BioMutaiCDK17
DMDMi59803097

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864871 – 523Cyclin-dependent kinase 17Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ00537
MaxQBiQ00537
PaxDbiQ00537
PeptideAtlasiQ00537
PRIDEiQ00537
ProteomicsDBi57855
57856 [Q00537-2]

PTM databases

iPTMnetiQ00537
PhosphoSitePlusiQ00537

Expressioni

Gene expression databases

BgeeiENSG00000059758 Expressed in 228 organ(s), highest expression level in corpus callosum
CleanExiHS_PCTK2
ExpressionAtlasiQ00537 baseline and differential
GenevisibleiQ00537 HS

Organism-specific databases

HPAiHPA015325

Interactioni

Subunit structurei

Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
YWHAZP631042EBI-624648,EBI-347088

Protein-protein interaction databases

BioGridi111155, 36 interactors
IntActiQ00537, 18 interactors
MINTiQ00537
STRINGi9606.ENSP00000261211

Chemistry databases

BindingDBiQ00537

Structurei

3D structure databases

ProteinModelPortaliQ00537
SMRiQ00537
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 473Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00900000140869
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ00537
KOiK15595
OMAiMKHAYFR
OrthoDBiEOG091G0CH0
PhylomeDBiQ00537
TreeFamiTF106508

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00537-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEENSSKDNE PIVKNGRPPT
60 70 80 90 100
SHSMHSFLHQ YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN
110 120 130 140 150
LKMGSDGESD QASGTSSDEV QSPTGVCLRN RIHRRISMED LNKRLSLPAD
160 170 180 190 200
IRIPDGYLEK LQINSPPFDQ PMSRRSRRAS LSEIGFGKME TYIKLEKLGE
210 220 230 240 250
GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKDLKHANI
260 270 280 290 300
VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG
310 320 330 340 350
LAYCHRRKVL HRDLKPQNLL INEKGELKLA DFGLARAKSV PTKTYSNEVV
360 370 380 390 400
TLWYRPPDVL LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL
410 420 430 440 450
IFRLLGTPSQ ETWPGISSNE EFKNYNFPKY KPQPLINHAP RLDSEGIELI
460 470 480 490 500
TKFLQYESKK RVSAEEAMKH VYFRSLGPRI HALPESVSIF SLKEIQLQKD
510 520
PGFRNSSYPE TGHGKNRRQS MLF
Length:523
Mass (Da):59,582
Last modified:February 15, 2005 - v2
Checksum:i429ABD1DCBB5A082
GO
Isoform 2 (identifier: Q00537-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-523: HGKNRRQSMLF → VFVINHFTCRS

Note: No experimental confirmation available.
Show »
Length:523
Mass (Da):59,531
Checksum:i5FD1C9DFC4B050C6
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6Z0F5H6Z0_HUMAN
Cyclin-dependent kinase 17
CDK17
470Annotation score:
F8VQZ9F8VQZ9_HUMAN
Cyclin-dependent kinase 17
CDK17
179Annotation score:
F8VZY6F8VZY6_HUMAN
Cyclin-dependent kinase 17
CDK17
161Annotation score:
F8W1S5F8W1S5_HUMAN
Cyclin-dependent kinase 17
CDK17
129Annotation score:
F8VUX2F8VUX2_HUMAN
Cyclin-dependent kinase 17
CDK17
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti367S → L in CAA47004 (PubMed:1639063).Curated1
Sequence conflicti433Q → E in CAA47004 (PubMed:1639063).Curated1
Sequence conflicti451T → R in CAA47004 (PubMed:1639063).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064743214T → I Found in a renal cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764448325Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043295513 – 523HGKNRRQSMLF → VFVINHFTCRS in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66360 mRNA Translation: CAA47004.1
AK290011 mRNA Translation: BAF82700.1
AK315214 mRNA Translation: BAG37649.1
AC125612 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97566.1
CH471054 Genomic DNA Translation: EAW97567.1
BC033005 mRNA Translation: AAH33005.1
CCDSiCCDS53819.1 [Q00537-2]
CCDS9061.1 [Q00537-1]
PIRiS23384
RefSeqiNP_001163935.1, NM_001170464.2 [Q00537-2]
NP_002586.2, NM_002595.4 [Q00537-1]
XP_016874894.1, XM_017019405.1 [Q00537-1]
XP_016874895.1, XM_017019406.1 [Q00537-1]
UniGeneiHs.506415

Genome annotation databases

EnsembliENST00000261211; ENSP00000261211; ENSG00000059758 [Q00537-1]
ENST00000543119; ENSP00000444459; ENSG00000059758 [Q00537-2]
GeneIDi5128
KEGGihsa:5128
UCSCiuc001tep.3 human [Q00537-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66360 mRNA Translation: CAA47004.1
AK290011 mRNA Translation: BAF82700.1
AK315214 mRNA Translation: BAG37649.1
AC125612 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97566.1
CH471054 Genomic DNA Translation: EAW97567.1
BC033005 mRNA Translation: AAH33005.1
CCDSiCCDS53819.1 [Q00537-2]
CCDS9061.1 [Q00537-1]
PIRiS23384
RefSeqiNP_001163935.1, NM_001170464.2 [Q00537-2]
NP_002586.2, NM_002595.4 [Q00537-1]
XP_016874894.1, XM_017019405.1 [Q00537-1]
XP_016874895.1, XM_017019406.1 [Q00537-1]
UniGeneiHs.506415

3D structure databases

ProteinModelPortaliQ00537
SMRiQ00537
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111155, 36 interactors
IntActiQ00537, 18 interactors
MINTiQ00537
STRINGi9606.ENSP00000261211

Chemistry databases

BindingDBiQ00537
ChEMBLiCHEMBL5790

PTM databases

iPTMnetiQ00537
PhosphoSitePlusiQ00537

Polymorphism and mutation databases

BioMutaiCDK17
DMDMi59803097

Proteomic databases

EPDiQ00537
MaxQBiQ00537
PaxDbiQ00537
PeptideAtlasiQ00537
PRIDEiQ00537
ProteomicsDBi57855
57856 [Q00537-2]

Protocols and materials databases

DNASUi5128
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261211; ENSP00000261211; ENSG00000059758 [Q00537-1]
ENST00000543119; ENSP00000444459; ENSG00000059758 [Q00537-2]
GeneIDi5128
KEGGihsa:5128
UCSCiuc001tep.3 human [Q00537-1]

Organism-specific databases

CTDi5128
DisGeNETi5128
EuPathDBiHostDB:ENSG00000059758.7
GeneCardsiCDK17
HGNCiHGNC:8750 CDK17
HPAiHPA015325
MIMi603440 gene
neXtProtiNX_Q00537
OpenTargetsiENSG00000059758
PharmGKBiPA33096
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00900000140869
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ00537
KOiK15595
OMAiMKHAYFR
OrthoDBiEOG091G0CH0
PhylomeDBiQ00537
TreeFamiTF106508

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
SignaLinkiQ00537

Miscellaneous databases

ChiTaRSiCDK17 human
GeneWikiiPCTK2
GenomeRNAii5128
PROiPR:Q00537
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000059758 Expressed in 228 organ(s), highest expression level in corpus callosum
CleanExiHS_PCTK2
ExpressionAtlasiQ00537 baseline and differential
GenevisibleiQ00537 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDK17_HUMAN
AccessioniPrimary (citable) accession number: Q00537
Secondary accession number(s): A8K1U6, B2RCQ2, Q8NEB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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