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Protein

Cyclin-dependent-like kinase 5

Gene

CDK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.21 Publications

Miscellaneous

Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson, and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), 1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1 (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39) by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Biological rhythms, Cell cycle, Cell division, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
ReactomeiR-HSA-180024 DARPP-32 events
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-9032845 Activated NTRK2 signals through CDK5
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiQ00535
SIGNORiQ00535

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent-like kinase 5 (EC:2.7.11.1)
Alternative name(s):
Cell division protein kinase 5
Serine/threonine-protein kinase PSSALRE
Tau protein kinase II catalytic subunit
Short name:
TPKII catalytic subunit
Gene namesi
Name:CDK5
Synonyms:CDKN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164885.12
HGNCiHGNC:1774 CDK5
MIMi123831 gene
neXtProtiNX_Q00535

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Lissencephaly 7, with cerebellar hypoplasia (LIS7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lissencephaly, a disorder of cortical development characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. LIS7 patients manifest lack of psychomotor development, facial dysmorphism, arthrogryposis, and early-onset intractable seizures resulting in death in infancy.
See also OMIM:616342

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi159S → A: No phenotype. 1 Publication1
Mutagenesisi159S → T: Impaired p35/p25 (CDK5R1) binding. 1 Publication1

Keywords - Diseasei

Lissencephaly, Neurodegeneration

Organism-specific databases

DisGeNETi1020
MalaCardsiCDK5
MIMi616342 phenotype
OpenTargetsiENSG00000164885
PharmGKBiPA26310

Chemistry databases

ChEMBLiCHEMBL4036
DrugBankiDB04014 Alsterpaullone
DB03496 Flavopiridol
DB02950 Hymenialdisine
DB02052 Indirubin-3'-Monoxime
DB02116 Olomoucine
DB03428 SU9516
GuidetoPHARMACOLOGYi1977

Polymorphism and mutation databases

BioMutaiCDK5
DMDMi4033704

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857841 – 292Cyclin-dependent-like kinase 5Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15Phosphotyrosine; by ABL1, EPHA4 and FYN2 Publications1
Modified residuei17PhosphothreonineCombined sources1
Modified residuei56N6-acetyllysineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei159Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity.3 Publications
Phosphorylation at Ser-159 is essential for maximal catalytic activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ00535
MaxQBiQ00535
PaxDbiQ00535
PeptideAtlasiQ00535
PRIDEiQ00535
ProteomicsDBi57852
57853 [Q00535-2]

PTM databases

iPTMnetiQ00535
PhosphoSitePlusiQ00535
SwissPalmiQ00535

Expressioni

Tissue specificityi

Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.2 Publications

Gene expression databases

BgeeiENSG00000164885 Expressed in 182 organ(s), highest expression level in frontal cortex
CleanExiHS_CDK5
ExpressionAtlasiQ00535 baseline and differential
GenevisibleiQ00535 HS

Organism-specific databases

HPAiCAB008909
HPA064535

Interactioni

Subunit structurei

Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts with PTK2/FAK1 (By similarity). The complex p35/CDK5 interacts with CLOCK. Interacts with HTR6 (By similarity).By similarity9 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107455, 110 interactors
ComplexPortaliCPX-2201 Cyclin-dependent protein kinase 5 holoenzyme complex, p35 variant
CPX-3141 Cyclin-dependent protein kinase 5 holoenzyme complex, p39 variant
CPX-3142 Cyclin-dependent protein kinase 5 holoenzyme complex, p25 variant
CORUMiQ00535
DIPiDIP-24221N
ELMiQ00535
IntActiQ00535, 53 interactors
MINTiQ00535
STRINGi9606.ENSP00000419782

Chemistry databases

BindingDBiQ00535

Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ00535
SMRiQ00535
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00535

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00910000144030
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ00535
KOiK02090
OMAiTVRSFMY
OrthoDBiEOG091G0CH0
PhylomeDBiQ00535
TreeFamiTF101023

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q00535-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR
60 70 80 90 100
EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP
110 120 130 140 150
EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA
160 170 180 190 200
FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR
210 220 230 240 250
PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN
260 270 280 290
VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP
Length:292
Mass (Da):33,304
Last modified:December 15, 1998 - v3
Checksum:i54D10495F017D527
GO
Isoform 2 (identifier: Q00535-2) [UniParc]FASTAAdd to basket
Also known as: CDK5-SV

The sequence of this isoform differs from the canonical sequence as follows:
     105-136: Missing.

Show »
Length:260
Mass (Da):29,544
Checksum:i808E46028B657622
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041977225E → D1 PublicationCorresponds to variant dbSNP:rs35186917Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041948105 – 136Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66364 mRNA Translation: CAA47007.1
DQ411039 mRNA Translation: ABD66016.1
AY049778 mRNA Translation: AAL15435.1
BT006680 mRNA Translation: AAP35326.1
AC010973 Genomic DNA No translation available.
BC005115 mRNA Translation: AAH05115.1
CCDSiCCDS47748.1 [Q00535-1]
CCDS55184.1 [Q00535-2]
PIRiS23386
RefSeqiNP_001157882.1, NM_001164410.2 [Q00535-2]
NP_004926.1, NM_004935.3 [Q00535-1]
UniGeneiHs.647078

Genome annotation databases

EnsembliENST00000297518; ENSP00000297518; ENSG00000164885 [Q00535-2]
ENST00000485972; ENSP00000419782; ENSG00000164885 [Q00535-1]
GeneIDi1020
KEGGihsa:1020
UCSCiuc003wir.3 human [Q00535-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66364 mRNA Translation: CAA47007.1
DQ411039 mRNA Translation: ABD66016.1
AY049778 mRNA Translation: AAL15435.1
BT006680 mRNA Translation: AAP35326.1
AC010973 Genomic DNA No translation available.
BC005115 mRNA Translation: AAH05115.1
CCDSiCCDS47748.1 [Q00535-1]
CCDS55184.1 [Q00535-2]
PIRiS23386
RefSeqiNP_001157882.1, NM_001164410.2 [Q00535-2]
NP_004926.1, NM_004935.3 [Q00535-1]
UniGeneiHs.647078

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H4LX-ray2.65A/B1-292[»]
1LFRmodel-A1-292[»]
1UNGX-ray2.30A/B1-292[»]
1UNHX-ray2.35A/B1-292[»]
1UNLX-ray2.20A/B1-292[»]
3O0GX-ray1.95A/B1-292[»]
4AU8X-ray1.90A/B2-292[»]
ProteinModelPortaliQ00535
SMRiQ00535
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107455, 110 interactors
ComplexPortaliCPX-2201 Cyclin-dependent protein kinase 5 holoenzyme complex, p35 variant
CPX-3141 Cyclin-dependent protein kinase 5 holoenzyme complex, p39 variant
CPX-3142 Cyclin-dependent protein kinase 5 holoenzyme complex, p25 variant
CORUMiQ00535
DIPiDIP-24221N
ELMiQ00535
IntActiQ00535, 53 interactors
MINTiQ00535
STRINGi9606.ENSP00000419782

Chemistry databases

BindingDBiQ00535
ChEMBLiCHEMBL4036
DrugBankiDB04014 Alsterpaullone
DB03496 Flavopiridol
DB02950 Hymenialdisine
DB02052 Indirubin-3'-Monoxime
DB02116 Olomoucine
DB03428 SU9516
GuidetoPHARMACOLOGYi1977

PTM databases

iPTMnetiQ00535
PhosphoSitePlusiQ00535
SwissPalmiQ00535

Polymorphism and mutation databases

BioMutaiCDK5
DMDMi4033704

Proteomic databases

EPDiQ00535
MaxQBiQ00535
PaxDbiQ00535
PeptideAtlasiQ00535
PRIDEiQ00535
ProteomicsDBi57852
57853 [Q00535-2]

Protocols and materials databases

DNASUi1020
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297518; ENSP00000297518; ENSG00000164885 [Q00535-2]
ENST00000485972; ENSP00000419782; ENSG00000164885 [Q00535-1]
GeneIDi1020
KEGGihsa:1020
UCSCiuc003wir.3 human [Q00535-1]

Organism-specific databases

CTDi1020
DisGeNETi1020
EuPathDBiHostDB:ENSG00000164885.12
GeneCardsiCDK5
HGNCiHGNC:1774 CDK5
HPAiCAB008909
HPA064535
MalaCardsiCDK5
MIMi123831 gene
616342 phenotype
neXtProtiNX_Q00535
OpenTargetsiENSG00000164885
PharmGKBiPA26310
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00910000144030
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ00535
KOiK02090
OMAiTVRSFMY
OrthoDBiEOG091G0CH0
PhylomeDBiQ00535
TreeFamiTF101023

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
ReactomeiR-HSA-180024 DARPP-32 events
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-9032845 Activated NTRK2 signals through CDK5
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiQ00535
SIGNORiQ00535

Miscellaneous databases

ChiTaRSiCDK5 human
EvolutionaryTraceiQ00535
GeneWikiiCyclin-dependent_kinase_5
GenomeRNAii1020
PROiPR:Q00535
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164885 Expressed in 182 organ(s), highest expression level in frontal cortex
CleanExiHS_CDK5
ExpressionAtlasiQ00535 baseline and differential
GenevisibleiQ00535 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDK5_HUMAN
AccessioniPrimary (citable) accession number: Q00535
Secondary accession number(s): A1XKG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 207 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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