UniProtKB - Q00535 (CDK5_HUMAN)
Cyclin-dependent-like kinase 5
CDK5
Functioni
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
21 PublicationsMiscellaneous
Catalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 126 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- acetylcholine receptor activator activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- ephrin receptor binding Source: Ensembl
- ErbB-2 class receptor binding Source: UniProtKB
- ErbB-3 class receptor binding Source: UniProtKB
- Hsp90 protein binding Source: Ensembl
- kinase activity Source: UniProtKB
- p53 binding Source: Ensembl
- protein kinase activity Source: ProtInc
- protein kinase binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- tau protein binding Source: ARUK-UCL
- tau-protein kinase activity Source: UniProtKB
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Source: Ensembl
GO - Biological processi
- axon extension Source: UniProtKB
- axonogenesis Source: GO_Central
- behavioral response to cocaine Source: Ensembl
- calcium ion import Source: Ensembl
- cell division Source: UniProtKB-KW
- cell-matrix adhesion Source: Ensembl
- cellular response to amyloid-beta Source: ARUK-UCL
- central nervous system neuron development Source: Ensembl
- cerebellar cortex formation Source: Ensembl
- chemical synaptic transmission Source: UniProtKB
- corpus callosum development Source: Ensembl
- cortical actin cytoskeleton organization Source: Ensembl
- dendrite morphogenesis Source: Ensembl
- excitatory postsynaptic potential Source: Ensembl
- hippocampus development Source: Ensembl
- histone phosphorylation Source: Ensembl
- intracellular protein transport Source: Ensembl
- layer formation in cerebral cortex Source: Ensembl
- microtubule cytoskeleton organization Source: ARUK-UCL
- mitochondrion organization Source: Ensembl
- motor neuron axon guidance Source: Ensembl
- negative regulation of axon extension Source: Ensembl
- negative regulation of cell cycle Source: Ensembl
- negative regulation of neuron death Source: ParkinsonsUK-UCL
- negative regulation of protein export from nucleus Source: Ensembl
- negative regulation of protein ubiquitination Source: Ensembl
- negative regulation of proteolysis Source: ParkinsonsUK-UCL
- negative regulation of synaptic plasticity Source: Ensembl
- negative regulation of transcription, DNA-templated Source: DFLAT
- neuron apoptotic process Source: GO_Central
- neuron differentiation Source: UniProtKB
- neuron migration Source: UniProtKB
- neuron projection development Source: UniProtKB
- nucleocytoplasmic transport Source: Ensembl
- oligodendrocyte differentiation Source: UniProtKB
- peptidyl-serine phosphorylation Source: UniProtKB
- peptidyl-threonine phosphorylation Source: ARUK-UCL
- phosphorylation Source: DFLAT
- positive regulation of actin cytoskeleton reorganization Source: UniProtKB
- positive regulation of calcium ion-dependent exocytosis Source: Ensembl
- positive regulation of glial cell apoptotic process Source: Ensembl
- positive regulation of neuron apoptotic process Source: UniProtKB
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein kinase activity Source: Ensembl
- positive regulation of protein targeting to membrane Source: Ensembl
- positive regulation of voltage-gated calcium channel activity Source: Ensembl
- protein autophosphorylation Source: Ensembl
- protein localization to synapse Source: Ensembl
- protein phosphorylation Source: GO_Central
- receptor catabolic process Source: Ensembl
- receptor clustering Source: Ensembl
- regulation of apoptotic process Source: UniProtKB
- regulation of cell cycle Source: UniProtKB
- regulation of cell migration Source: Ensembl
- regulation of dendritic spine morphogenesis Source: UniProtKB
- regulation of macroautophagy Source: ParkinsonsUK-UCL
- regulation of protein localization to plasma membrane Source: ARUK-UCL
- regulation of synaptic plasticity Source: UniProtKB
- regulation of synaptic transmission, glutamatergic Source: ARUK-UCL
- regulation of synaptic vesicle recycling Source: ParkinsonsUK-UCL
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: GO_Central
- response to wounding Source: Ensembl
- rhythmic process Source: UniProtKB-KW
- Schwann cell development Source: Ensembl
- sensory perception of pain Source: Ensembl
- serine phosphorylation of STAT protein Source: Ensembl
- skeletal muscle tissue development Source: Ensembl
- synapse assembly Source: UniProtKB
- synapse pruning Source: Ensembl
- synaptic transmission, dopaminergic Source: Ensembl
- synaptic transmission, glutamatergic Source: Ensembl
- synaptic vesicle endocytosis Source: UniProtKB
- synaptic vesicle exocytosis Source: UniProtKB
- synaptic vesicle transport Source: GO_Central
- visual learning Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Biological rhythms, Cell cycle, Cell division, Neurogenesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | Q00535 |
Reactomei | R-HSA-180024, DARPP-32 events R-HSA-399956, CRMPs in Sema3A signaling R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-9031628, NGF-stimulated transcription R-HSA-9032845, Activated NTRK2 signals through CDK5 R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | Q00535 |
SIGNORi | Q00535 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent-like kinase 5 (EC:2.7.11.1)Alternative name(s): Cell division protein kinase 5 Serine/threonine-protein kinase PSSALRE Tau protein kinase II catalytic subunit Short name: TPKII catalytic subunit |
Gene namesi | Name:CDK5 Synonyms:CDKN5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1774, CDK5 |
MIMi | 123831, gene |
neXtProti | NX_Q00535 |
VEuPathDBi | HostDB:ENSG00000164885 |
Subcellular locationi
Cytoplasm and Cytosol
Plasma membrane
Other locations
- Perikaryon
- lamellipodium By similarity
- growth cone By similarity
- postsynaptic density By similarity
Note: In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5.By similarity
Nucleus
Cytoskeleton
- microtubule Source: Ensembl
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- axon Source: UniProtKB
- cell junction Source: HPA
- cyclin-dependent protein kinase holoenzyme complex Source: ComplexPortal
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB
- filopodium Source: Ensembl
- glutamatergic synapse Source: Ensembl
- growth cone Source: UniProtKB
- lamellipodium Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- neuromuscular junction Source: UniProtKB
- neuron projection Source: ARUK-UCL
- neuronal cell body Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
- postsynaptic density Source: UniProtKB
- presynapse Source: Ensembl
- protein kinase 5 complex Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, SynapsePathology & Biotechi
Involvement in diseasei
Lissencephaly 7, with cerebellar hypoplasia (LIS7)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 159 | S → A: No phenotype. 1 Publication | 1 | |
Mutagenesisi | 159 | S → T: Impaired p35/p25 (CDK5R1) binding. 1 Publication | 1 |
Keywords - Diseasei
Lissencephaly, NeurodegenerationOrganism-specific databases
DisGeNETi | 1020 |
MalaCardsi | CDK5 |
MIMi | 616342, phenotype |
OpenTargetsi | ENSG00000164885 |
PharmGKBi | PA26310 |
Miscellaneous databases
Pharosi | Q00535, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4036 |
DrugBanki | DB07364, 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE DB04014, Alsterpaullone DB03496, Alvocidib DB02950, Hymenialdisine DB02052, Indirubin-3'-monoxime DB02116, Olomoucine DB03428, SU9516 |
DrugCentrali | Q00535 |
GuidetoPHARMACOLOGYi | 1977 |
Genetic variation databases
BioMutai | CDK5 |
DMDMi | 4033704 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085784 | 1 – 292 | Cyclin-dependent-like kinase 5Add BLAST | 292 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | Phosphotyrosine; by ABL1, EPHA4 and FYN2 Publications | 1 | |
Modified residuei | 17 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 56 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 72 | PhosphoserineCombined sources | 1 | |
Modified residuei | 159 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q00535 |
jPOSTi | Q00535 |
MassIVEi | Q00535 |
MaxQBi | Q00535 |
PaxDbi | Q00535 |
PeptideAtlasi | Q00535 |
PRIDEi | Q00535 |
ProteomicsDBi | 57852 [Q00535-1] 57853 [Q00535-2] |
PTM databases
GlyGeni | Q00535, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q00535 |
PhosphoSitePlusi | Q00535 |
SwissPalmi | Q00535 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000164885, Expressed in prefrontal cortex and 196 other tissues |
ExpressionAtlasi | Q00535, baseline and differential |
Genevisiblei | Q00535, HS |
Organism-specific databases
HPAi | ENSG00000164885, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic.
Found in a trimolecular complex with CABLES1 and ABL1.
Interacts with CABLES1 and CABLES2 (By similarity).
Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1.
Interacts with delta-catenin/CTNND2 and APEX1.
Interacts with P53/TP53 in neurons.
Interacts with EPHA4; may mediate the activation of NGEF by EPHA4.
Interacts with PTK2/FAK1 (By similarity). The complex p35/CDK5 interacts with CLOCK.
Interacts with HTR6 (By similarity).
By similarity9 PublicationsBinary interactionsi
Q00535
GO - Molecular functioni
- ephrin receptor binding Source: Ensembl
- ErbB-2 class receptor binding Source: UniProtKB
- ErbB-3 class receptor binding Source: UniProtKB
- Hsp90 protein binding Source: Ensembl
- p53 binding Source: Ensembl
- protein kinase binding Source: Ensembl
- tau protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 107455, 156 interactors |
ComplexPortali | CPX-2201, Cyclin-dependent protein kinase 5 holoenzyme complex, p35 variant CPX-3141, Cyclin-dependent protein kinase 5 holoenzyme complex, p39 variant CPX-3142, Cyclin-dependent protein kinase 5 holoenzyme complex, p25 variant |
CORUMi | Q00535 |
DIPi | DIP-24221N |
ELMi | Q00535 |
IntActi | Q00535, 72 interactors |
MINTi | Q00535 |
STRINGi | 9606.ENSP00000419782 |
Chemistry databases
BindingDBi | Q00535 |
Miscellaneous databases
RNActi | Q00535, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q00535 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q00535 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 286 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 283 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0662, Eukaryota |
GeneTreei | ENSGT00940000160805 |
HOGENOMi | CLU_000288_181_1_1 |
InParanoidi | Q00535 |
OMAi | QHPWFND |
PhylomeDBi | Q00535 |
TreeFami | TF101023 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR
60 70 80 90 100
EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP
110 120 130 140 150
EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA
160 170 180 190 200
FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR
210 220 230 240 250
PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN
260 270 280 290
VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041977 | 225 | E → D1 PublicationCorresponds to variant dbSNP:rs35186917Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041948 | 105 – 136 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66364 mRNA Translation: CAA47007.1 DQ411039 mRNA Translation: ABD66016.1 AY049778 mRNA Translation: AAL15435.1 BT006680 mRNA Translation: AAP35326.1 AC010973 Genomic DNA No translation available. BC005115 mRNA Translation: AAH05115.1 |
CCDSi | CCDS47748.1 [Q00535-1] CCDS55184.1 [Q00535-2] |
PIRi | S23386 |
RefSeqi | NP_001157882.1, NM_001164410.2 [Q00535-2] NP_004926.1, NM_004935.3 [Q00535-1] |
Genome annotation databases
Ensembli | ENST00000297518; ENSP00000297518; ENSG00000164885 [Q00535-2] ENST00000485972; ENSP00000419782; ENSG00000164885 |
GeneIDi | 1020 |
KEGGi | hsa:1020 |
MANE-Selecti | ENST00000485972.6; ENSP00000419782.1; NM_004935.4; NP_004926.1 |
UCSCi | uc003wir.3, human [Q00535-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66364 mRNA Translation: CAA47007.1 DQ411039 mRNA Translation: ABD66016.1 AY049778 mRNA Translation: AAL15435.1 BT006680 mRNA Translation: AAP35326.1 AC010973 Genomic DNA No translation available. BC005115 mRNA Translation: AAH05115.1 |
CCDSi | CCDS47748.1 [Q00535-1] CCDS55184.1 [Q00535-2] |
PIRi | S23386 |
RefSeqi | NP_001157882.1, NM_001164410.2 [Q00535-2] NP_004926.1, NM_004935.3 [Q00535-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1H4L | X-ray | 2.65 | A/B | 1-292 | [»] | |
1UNG | X-ray | 2.30 | A/B | 1-292 | [»] | |
1UNH | X-ray | 2.35 | A/B | 1-292 | [»] | |
1UNL | X-ray | 2.20 | A/B | 1-292 | [»] | |
3O0G | X-ray | 1.95 | A/B | 1-292 | [»] | |
4AU8 | X-ray | 1.90 | A/B | 2-292 | [»] | |
SMRi | Q00535 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107455, 156 interactors |
ComplexPortali | CPX-2201, Cyclin-dependent protein kinase 5 holoenzyme complex, p35 variant CPX-3141, Cyclin-dependent protein kinase 5 holoenzyme complex, p39 variant CPX-3142, Cyclin-dependent protein kinase 5 holoenzyme complex, p25 variant |
CORUMi | Q00535 |
DIPi | DIP-24221N |
ELMi | Q00535 |
IntActi | Q00535, 72 interactors |
MINTi | Q00535 |
STRINGi | 9606.ENSP00000419782 |
Chemistry databases
BindingDBi | Q00535 |
ChEMBLi | CHEMBL4036 |
DrugBanki | DB07364, 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE DB04014, Alsterpaullone DB03496, Alvocidib DB02950, Hymenialdisine DB02052, Indirubin-3'-monoxime DB02116, Olomoucine DB03428, SU9516 |
DrugCentrali | Q00535 |
GuidetoPHARMACOLOGYi | 1977 |
PTM databases
GlyGeni | Q00535, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q00535 |
PhosphoSitePlusi | Q00535 |
SwissPalmi | Q00535 |
Genetic variation databases
BioMutai | CDK5 |
DMDMi | 4033704 |
Proteomic databases
EPDi | Q00535 |
jPOSTi | Q00535 |
MassIVEi | Q00535 |
MaxQBi | Q00535 |
PaxDbi | Q00535 |
PeptideAtlasi | Q00535 |
PRIDEi | Q00535 |
ProteomicsDBi | 57852 [Q00535-1] 57853 [Q00535-2] |
Protocols and materials databases
Antibodypediai | 4556, 1032 antibodies from 42 providers |
DNASUi | 1020 |
Genome annotation databases
Ensembli | ENST00000297518; ENSP00000297518; ENSG00000164885 [Q00535-2] ENST00000485972; ENSP00000419782; ENSG00000164885 |
GeneIDi | 1020 |
KEGGi | hsa:1020 |
MANE-Selecti | ENST00000485972.6; ENSP00000419782.1; NM_004935.4; NP_004926.1 |
UCSCi | uc003wir.3, human [Q00535-1] |
Organism-specific databases
CTDi | 1020 |
DisGeNETi | 1020 |
GeneCardsi | CDK5 |
HGNCi | HGNC:1774, CDK5 |
HPAi | ENSG00000164885, Tissue enhanced (brain) |
MalaCardsi | CDK5 |
MIMi | 123831, gene 616342, phenotype |
neXtProti | NX_Q00535 |
OpenTargetsi | ENSG00000164885 |
PharmGKBi | PA26310 |
VEuPathDBi | HostDB:ENSG00000164885 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0662, Eukaryota |
GeneTreei | ENSGT00940000160805 |
HOGENOMi | CLU_000288_181_1_1 |
InParanoidi | Q00535 |
OMAi | QHPWFND |
PhylomeDBi | Q00535 |
TreeFami | TF101023 |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | Q00535 |
Reactomei | R-HSA-180024, DARPP-32 events R-HSA-399956, CRMPs in Sema3A signaling R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-9031628, NGF-stimulated transcription R-HSA-9032845, Activated NTRK2 signals through CDK5 R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | Q00535 |
SIGNORi | Q00535 |
Miscellaneous databases
BioGRID-ORCSi | 1020, 23 hits in 1088 CRISPR screens |
ChiTaRSi | CDK5, human |
EvolutionaryTracei | Q00535 |
GeneWikii | Cyclin-dependent_kinase_5 |
GenomeRNAii | 1020 |
Pharosi | Q00535, Tchem |
PROi | PR:Q00535 |
RNActi | Q00535, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164885, Expressed in prefrontal cortex and 196 other tissues |
ExpressionAtlasi | Q00535, baseline and differential |
Genevisiblei | Q00535, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDK5_HUMAN | |
Accessioni | Q00535Primary (citable) accession number: Q00535 Secondary accession number(s): A1XKG3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 229 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families