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Protein

Cyclin-dependent kinase 3

Gene

CDK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei127Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: UniProtKB
  • cellular response to DNA damage stimulus Source: MGI
  • G0 to G1 transition Source: UniProtKB
  • G1/S transition of mitotic cell cycle Source: UniProtKB
  • multicellular organism development Source: GO_Central
  • positive regulation of cell proliferation Source: GO_Central
  • protein phosphorylation Source: GO_Central
  • regulation of G2/M transition of mitotic cell cycle Source: GO_Central
  • regulation of gene expression Source: GO_Central
  • response to organic substance Source: GO_Central
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
SignaLinkiQ00526
SIGNORiQ00526

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 3 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 3
Gene namesi
Name:CDK3
Synonyms:CDKN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000250506.6
HGNCiHGNC:1772 CDK3
MIMi123828 gene
neXtProtiNX_Q00526

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1018
OpenTargetsiENSG00000250506
PharmGKBiPA26309

Chemistry databases

ChEMBLiCHEMBL4442
GuidetoPHARMACOLOGYi1975

Polymorphism and mutation databases

BioMutaiCDK3
DMDMi231726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857761 – 305Cyclin-dependent kinase 3Add BLAST305

Proteomic databases

EPDiQ00526
MaxQBiQ00526
PaxDbiQ00526
PeptideAtlasiQ00526
PRIDEiQ00526
ProteomicsDBi57848

PTM databases

iPTMnetiQ00526
PhosphoSitePlusiQ00526

Expressioni

Tissue specificityi

Expressed in cancer cell lines and glioblastoma tissue.1 Publication

Gene expression databases

BgeeiENSG00000250506
CleanExiHS_CDK3
ExpressionAtlasiQ00526 baseline and differential
GenevisibleiQ00526 HS

Organism-specific databases

HPAiHPA007420

Interactioni

Subunit structurei

Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107453, 50 interactors
ComplexPortaliCPX-330 Cyclin C-CDK3 complex
CORUMiQ00526
DIPiDIP-686N
ELMiQ00526
IntActiQ00526, 43 interactors
MINTiQ00526
STRINGi9606.ENSP00000400088

Chemistry databases

BindingDBiQ00526

Structurei

3D structure databases

ProteinModelPortaliQ00526
SMRiQ00526
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00910000144030
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ00526
KOiK02088
OMAiCVLERFC
OrthoDBiEOG091G0CH0
PhylomeDBiQ00526
TreeFamiTF101021

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q00526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMFQKVEKI GEGTYGVVYK AKNRETGQLV ALKKIRLDLE MEGVPSTAIR
60 70 80 90 100
EISLLKELKH PNIVRLLDVV HNERKLYLVF EFLSQDLKKY MDSTPGSELP
110 120 130 140 150
LHLIKSYLFQ LLQGVSFCHS HRVIHRDLKP QNLLINELGA IKLADFGLAR
160 170 180 190 200
AFGVPLRTYT HEVVTLWYRA PEILLGSKFY TTAVDIWSIG CIFAEMVTRK
210 220 230 240 250
ALFPGDSEID QLFRIFRMLG TPSEDTWPGV TQLPDYKGSF PKWTRKGLEE
260 270 280 290 300
IVPNLEPEGR DLLMQLLQYD PSQRITAKTA LAHPYFSSPE PSPAARQYVL

QRFRH
Length:305
Mass (Da):35,046
Last modified:April 1, 1993 - v1
Checksum:i1128BE0096EA262A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041973106S → N in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_041974124I → T1 PublicationCorresponds to variant dbSNP:rs34918446Ensembl.1
Natural variantiVAR_041975214R → H1 PublicationCorresponds to variant dbSNP:rs34670267Ensembl.1
Natural variantiVAR_021101226T → I1 PublicationCorresponds to variant dbSNP:rs2069532Ensembl.1
Natural variantiVAR_021102264M → T2 PublicationsCorresponds to variant dbSNP:rs17884251Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66357 mRNA Translation: CAA47001.1
AY789470 Genomic DNA Translation: AAV40830.1
CCDSiCCDS11736.1
PIRiS23382
RefSeqiNP_001249.1, NM_001258.2
UniGeneiHs.706766

Genome annotation databases

EnsembliENST00000425876; ENSP00000410561; ENSG00000250506
ENST00000448471; ENSP00000400088; ENSG00000250506
GeneIDi1018
KEGGihsa:1018
UCSCiuc010dgt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCDK3_HUMAN
AccessioniPrimary (citable) accession number: Q00526
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 20, 2018
This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

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