UniProtKB - Q00403 (TF2B_HUMAN)
Transcription initiation factor IIB
GTF2B
Functioni
Catalytic activityi
- EC:2.3.1.481 Publication
Kineticsi
- KM=0.117 mM for acetyl-CoA1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 15 | ZincCombined sources2 Publications | 1 | |
Metal bindingi | 18 | Zinc; via tele nitrogenCombined sources2 Publications | 1 | |
Metal bindingi | 34 | ZincCombined sources2 Publications | 1 | |
Metal bindingi | 37 | ZincCombined sources2 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 11 – 42 | TFIIB-typePROSITE-ProRule annotationAdd BLAST | 32 |
GO - Molecular functioni
- acetyltransferase activity Source: UniProtKB
- core promoter sequence-specific DNA binding Source: UniProtKB
- histone acetyltransferase activity Source: UniProtKB-EC
- promoter-specific chromatin binding Source: UniProtKB
- RNA polymerase II complex binding Source: UniProtKB
- RNA polymerase II complex recruiting activity Source: GO_Central
- RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
- RNA polymerase II general transcription initiation factor activity Source: ARUK-UCL
- TBP-class protein binding Source: CAFA
- thyroid hormone receptor binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- DNA-templated transcription, initiation Source: GO_Central
- positive regulation by host of viral transcription Source: UniProtKB
- positive regulation of core promoter binding Source: CAFA
- positive regulation of transcription initiation from RNA polymerase II promoter Source: UniProtKB
- positive regulation of viral transcription Source: AgBase
- protein acetylation Source: UniProtKB
- RNA polymerase II core complex assembly Source: UniProtKB
- RNA polymerase II preinitiation complex assembly Source: UniProtKB
- snRNA transcription by RNA polymerase II Source: Reactome
- transcriptional start site selection at RNA polymerase II promoter Source: UniProtKB
- transcription by RNA polymerase II Source: ARUK-UCL
- transcription initiation from RNA polymerase II promoter Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Acyltransferase, DNA-binding, Transferase |
Biological process | Host-virus interaction, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q00403 |
Reactomei | R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6807505, RNA polymerase II transcribes snRNA genes R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
SIGNORi | Q00403 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor IIB1 Publication (EC:2.3.1.481 Publication)Alternative name(s): General transcription factor TFIIB1 Publication S300-II1 Publication |
Gene namesi | Name:GTF2B Synonyms:TF2B, TFIIB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137947.11 |
HGNCi | HGNC:4648, GTF2B |
MIMi | 189963, gene |
neXtProti | NX_Q00403 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Chromosome 1 Publication
Note: Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis (PubMed:24441171). Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle (PubMed:24441171).1 Publication
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- transcription factor TFIID complex Source: UniProtKB
Other locations
- chromosome Source: UniProtKB
- protein-DNA complex Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: UniProtKB
- transcription preinitiation complex Source: CAFA
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 37 | C → S: Does not inhibit interaction with TBP. Inhibits the recruitment of RNA polymerase II into the initiation complex. 1 Publication | 1 | |
Mutagenesisi | 51 – 56 | EWRTFS → AWRTFA: Partial loss of HIV-1 Vpr binding. 1 Publication | 6 | |
Mutagenesisi | 51 | E → R, A or D: Defects in transcription start site selection. Supports a level of transcription equivalent to wild-type. 1 Publication | 1 | |
Mutagenesisi | 52 | W → A: Partial loss of HIV-1 Vpr binding. 1 Publication | 1 | |
Mutagenesisi | 53 – 54 | RT → AA: Partial loss of HIV-1 Vpr binding. 1 Publication | 2 | |
Mutagenesisi | 55 | F → A: Partial loss of HIV-1 Vpr binding. 1 Publication | 1 | |
Mutagenesisi | 66 | R → A, E or K: Defects in transcription start site selection. Supports a level of transcription equivalent to wild-type. 1 Publication | 1 | |
Mutagenesisi | 153 | G → Q: Decreases BREd-dependent pre-initiation complex formation. 1 Publication | 1 | |
Mutagenesisi | 185 | R → E: Reduces interaction with SSU72; when associated with E-193 or E-200. Inhibits interaction with VP16; when associated with E-193. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription; when associated with E-193. 2 Publications | 1 | |
Mutagenesisi | 185 | R → L: Reduces interaction with VP16; when associated with L-189. 1 Publication | 1 | |
Mutagenesisi | 189 | K → E: Inhibits interaction with SSU72; when associated with E-193. Reduces interaction with SSU72; when associated with E-200. Inhibits interaction with VP16; when associated with E-200. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription; when associated with E-200. 2 Publications | 1 | |
Mutagenesisi | 189 | K → L: Reduces interaction with VP16; when associated with L-185. 1 Publication | 1 | |
Mutagenesisi | 193 | R → E: Inhibits interaction with SSU72; when associated with E-185 or E-189. Inhibits interaction with VP16; when associated with E-185. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription; when associated with E-185. 2 Publications | 1 | |
Mutagenesisi | 196 | K → L: Reduces interaction with VP16; when associated with L-200. 1 Publication | 1 | |
Mutagenesisi | 200 – 208 | KALETSVDL → GSGS: Reduces the formation of the TATA box-bound TBP ternary complex. 1 Publication | 9 | |
Mutagenesisi | 200 | K → E: Reduces interaction with SSU72; when associated with E-185 or E-189. Inhibits interaction with VP16; when associated with E-189. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription; when associated with E-189. 2 Publications | 1 | |
Mutagenesisi | 200 | K → KGSGS: Reduces the formation of the TATA box-bound TBP ternary complex. 1 Publication | 1 | |
Mutagenesisi | 200 | K → L: Reduces interaction with VP16; when associated with L-196. 1 Publication | 1 | |
Mutagenesisi | 208 | L → LGSGS: Does not inhibit the formation of the TATA box-bound TBP ternary complex. 1 Publication | 1 | |
Mutagenesisi | 238 | K → A: Abolishes autoacetylation, represses transcription activity, does not inhibit its association with chromatin to promoter-specific regions and decreases the association of GTF2F1 with chromatin to promoter-specific regions. 1 Publication | 1 | |
Mutagenesisi | 247 | G → V: Inhibits interaction with TBP. 1 Publication | 1 | |
Mutagenesisi | 283 | V → A: Reduces DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 286 | R → A: Reduces DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 286 | R → E: Inhibits interaction with RNA polymerase II; when associated with E-290 and E-295. 1 Publication | 1 | |
Mutagenesisi | 290 | R → E: Inhibits interaction with RNA polymerase II; when associated with E-286 and E-295. 1 Publication | 1 | |
Mutagenesisi | 295 | R → E: Inhibits interaction with RNA polymerase II; when associated with E-286 and E-290. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2959 |
OpenTargetsi | ENSG00000137947 |
PharmGKBi | PA29035 |
Miscellaneous databases
Pharosi | Q00403, Tbio |
Polymorphism and mutation databases
BioMutai | GTF2B |
DMDMi | 135629 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119293 | 1 – 316 | Transcription initiation factor IIBAdd BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 70 | PhosphoserineCombined sources | 1 | |
Modified residuei | 76 | PhosphoserineCombined sources | 1 | |
Modified residuei | 92 | PhosphoserineCombined sources | 1 | |
Modified residuei | 238 | N6-acetyllysine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q00403 |
jPOSTi | Q00403 |
MassIVEi | Q00403 |
MaxQBi | Q00403 |
PaxDbi | Q00403 |
PeptideAtlasi | Q00403 |
PRIDEi | Q00403 |
ProteomicsDBi | 57846 |
PTM databases
iPTMneti | Q00403 |
MetOSitei | Q00403 |
PhosphoSitePlusi | Q00403 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000137947, Expressed in oocyte and 237 other tissues |
ExpressionAtlasi | Q00403, baseline and differential |
Genevisiblei | Q00403, HS |
Organism-specific databases
HPAi | ENSG00000137947, Low tissue specificity |
Interactioni
Subunit structurei
Found in a ternary complex with TATA box-bound TBP (PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:10619841, PubMed:29158257).
Part of a TFIID-containing RNA polymerase II pre-initiation complex (PIC) that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27193682). Associates with TFIID-TFIIA (DA complex) to form TFIID-TFIIA-TFIIB (DAB complex), which is then recognized by RNA polymerase II (Pol II) (PubMed:1876184, PubMed:2247058).
Found in a RNA polymerase II initiation complex (PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8516312, PubMed:7601352).
Interacts (via C-terminus) with TBP; this interaction with TATA box-bound TBP guides Pol II into the PIC (PubMed:8504927, PubMed:10619841).
Interacts (via N-terminus) with Pol II (PubMed:8504927, PubMed:8413225).
Interacts (via C-terminus) with SSU72; this interaction is inhibited by SYMPK (PubMed:29158257).
Interacts with NR2F1; this interaction is direct (PubMed:1517211).
Interacts with PGR (PubMed:1517211).
Interacts with ESR1 (PubMed:1517211).
Interacts with GTF2F1 (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2 (PubMed:8662660, PubMed:12931194).
Interacts with GTF2F2 (via N-terminus); this interaction is inhibited in presence of GTF2F1 (PubMed:8504927, PubMed:8662660).
Interacts with the transcription elongation factor TCEA2 (PubMed:8566795).
Interacts with HSF1 (via transactivation domain) (PubMed:11005381).
Interacts with GPBP1 (By similarity).
By similarity18 Publications(Microbial infection) Interacts with HIV-1 Vpr.
1 Publication(Microbial infection) Interacts with Epstein-Barr virus EBNA2.
1 Publication(Microbial infection) Interacts with Herpes simplex virus 1 protein ICP4.
1 Publication(Microbial infection) Interacts (via C-terminus) with the Herpes simplex virus activator VP16; this interaction stimulates RNA Pol II transcription by increasing the extent of pre-initiation complex assembly.
2 PublicationsBinary interactionsi
Hide detailsQ00403
GO - Molecular functioni
- RNA polymerase II complex binding Source: UniProtKB
- RNA polymerase II complex recruiting activity Source: GO_Central
- TBP-class protein binding Source: CAFA
- thyroid hormone receptor binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109214, 96 interactors |
CORUMi | Q00403 |
DIPi | DIP-1077N |
IntActi | Q00403, 55 interactors |
MINTi | Q00403 |
STRINGi | 9606.ENSP00000359531 |
Miscellaneous databases
RNActi | Q00403, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q00403 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q00403 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 124 – 200 | 1Add BLAST | 77 | |
Repeati | 218 – 294 | 2Add BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 189 – 193 | Core promoter DNA-binding1 Publication | 5 | |
Regioni | 244 – 316 | Necessary for TATA box-bound TBP complex formation2 PublicationsAdd BLAST | 73 | |
Regioni | 249 – 252 | Core promoter DNA-binding1 Publication | 4 | |
Regioni | 283 – 286 | Core promoter DNA-binding2 Publications | 4 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 11 – 42 | TFIIB-typePROSITE-ProRule annotationAdd BLAST | 32 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1597, Eukaryota |
GeneTreei | ENSGT00390000006671 |
InParanoidi | Q00403 |
OMAi | DQRMKRS |
OrthoDBi | 729732at2759 |
PhylomeDBi | Q00403 |
TreeFami | TF105953 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
IDEALi | IID00314 |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR000812, TFIIB IPR023486, TFIIB_CS IPR013150, TFIIB_cyclin IPR013137, Znf_TFIIB |
PANTHERi | PTHR11618, PTHR11618, 1 hit |
Pfami | View protein in Pfam PF08271, TF_Zn_Ribbon, 1 hit PF00382, TFIIB, 2 hits |
PRINTSi | PR00685, TIFACTORIIB |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00782, TFIIB, 2 hits PS51134, ZF_TFIIB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS
60 70 80 90 100
EWRTFSNDKA TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK
110 120 130 140 150
YQNRRTMSSS DRAMMNAFKE ITTMADRINL PRNIVDRTNN LFKQVYEQKS
160 170 180 190 200
LKGRANDAIA SACLYIACRQ EGVPRTFKEI CAVSRISKKE IGRCFKLILK
210 220 230 240 250
ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV ELDLVPGRSP
260 270 280 290 300
ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF
310
PTDFKFDTPV DKLPQL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1APE2 | B1APE2_HUMAN | General transcription factor TFIIB | GTF2B | 231 | Annotation score: | ||
B1APE1 | B1APE1_HUMAN | General transcription factor TFIIB | GTF2B | 224 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011977 | 19 | P → S. Corresponds to variant dbSNP:rs1804499Ensembl. | 1 | |
Natural variantiVAR_035722 | 132 | R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs144944840Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59268 mRNA Translation: CAA41958.1 M76766 mRNA Translation: AAA61149.1 AK289822 mRNA Translation: BAF82511.1 AB451296 mRNA Translation: BAG70110.1 AL445991 Genomic DNA No translation available. BC020597 mRNA Translation: AAH20597.1 S44184 mRNA Translation: AAB23144.1 |
CCDSi | CCDS715.1 |
PIRi | S17654, TWHU2B |
RefSeqi | NP_001505.1, NM_001514.5 |
Genome annotation databases
Ensembli | ENST00000370500; ENSP00000359531; ENSG00000137947 |
GeneIDi | 2959 |
KEGGi | hsa:2959 |
UCSCi | uc001dmo.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59268 mRNA Translation: CAA41958.1 M76766 mRNA Translation: AAA61149.1 AK289822 mRNA Translation: BAF82511.1 AB451296 mRNA Translation: BAG70110.1 AL445991 Genomic DNA No translation available. BC020597 mRNA Translation: AAH20597.1 S44184 mRNA Translation: AAB23144.1 |
CCDSi | CCDS715.1 |
PIRi | S17654, TWHU2B |
RefSeqi | NP_001505.1, NM_001514.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1C9B | X-ray | 2.65 | A/E/I/M/Q | 110-316 | [»] | |
1DL6 | NMR | - | A | 2-59 | [»] | |
1RLY | NMR | - | A | 1-60 | [»] | |
1RO4 | NMR | - | A | 1-60 | [»] | |
1TFB | NMR | - | A | 112-316 | [»] | |
1VOL | X-ray | 2.70 | A | 113-316 | [»] | |
2PHG | NMR | - | A | 112-316 | [»] | |
5IY6 | electron microscopy | 7.20 | M | 1-316 | [»] | |
5IY7 | electron microscopy | 8.60 | M | 1-316 | [»] | |
5IY8 | electron microscopy | 7.90 | M | 1-316 | [»] | |
5IY9 | electron microscopy | 6.30 | M | 1-316 | [»] | |
5IYA | electron microscopy | 5.40 | M | 1-316 | [»] | |
5IYB | electron microscopy | 3.90 | M | 1-316 | [»] | |
5IYC | electron microscopy | 3.90 | M | 1-316 | [»] | |
5IYD | electron microscopy | 3.90 | M | 1-316 | [»] | |
5WH1 | X-ray | 3.39 | A/B/C/D | 107-316 | [»] | |
6O9L | electron microscopy | 7.20 | M | 1-316 | [»] | |
SMRi | Q00403 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109214, 96 interactors |
CORUMi | Q00403 |
DIPi | DIP-1077N |
IntActi | Q00403, 55 interactors |
MINTi | Q00403 |
STRINGi | 9606.ENSP00000359531 |
PTM databases
iPTMneti | Q00403 |
MetOSitei | Q00403 |
PhosphoSitePlusi | Q00403 |
Polymorphism and mutation databases
BioMutai | GTF2B |
DMDMi | 135629 |
Proteomic databases
EPDi | Q00403 |
jPOSTi | Q00403 |
MassIVEi | Q00403 |
MaxQBi | Q00403 |
PaxDbi | Q00403 |
PeptideAtlasi | Q00403 |
PRIDEi | Q00403 |
ProteomicsDBi | 57846 |
Protocols and materials databases
Antibodypediai | 19819, 417 antibodies |
DNASUi | 2959 |
Genome annotation databases
Ensembli | ENST00000370500; ENSP00000359531; ENSG00000137947 |
GeneIDi | 2959 |
KEGGi | hsa:2959 |
UCSCi | uc001dmo.5, human |
Organism-specific databases
CTDi | 2959 |
DisGeNETi | 2959 |
EuPathDBi | HostDB:ENSG00000137947.11 |
GeneCardsi | GTF2B |
HGNCi | HGNC:4648, GTF2B |
HPAi | ENSG00000137947, Low tissue specificity |
MIMi | 189963, gene |
neXtProti | NX_Q00403 |
OpenTargetsi | ENSG00000137947 |
PharmGKBi | PA29035 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1597, Eukaryota |
GeneTreei | ENSGT00390000006671 |
InParanoidi | Q00403 |
OMAi | DQRMKRS |
OrthoDBi | 729732at2759 |
PhylomeDBi | Q00403 |
TreeFami | TF105953 |
Enzyme and pathway databases
PathwayCommonsi | Q00403 |
Reactomei | R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6807505, RNA polymerase II transcribes snRNA genes R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
SIGNORi | Q00403 |
Miscellaneous databases
BioGRID-ORCSi | 2959, 762 hits in 850 CRISPR screens |
ChiTaRSi | GTF2B, human |
EvolutionaryTracei | Q00403 |
GeneWikii | Transcription_factor_II_B |
GenomeRNAii | 2959 |
Pharosi | Q00403, Tbio |
PROi | PR:Q00403 |
RNActi | Q00403, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137947, Expressed in oocyte and 237 other tissues |
ExpressionAtlasi | Q00403, baseline and differential |
Genevisiblei | Q00403, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
IDEALi | IID00314 |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR000812, TFIIB IPR023486, TFIIB_CS IPR013150, TFIIB_cyclin IPR013137, Znf_TFIIB |
PANTHERi | PTHR11618, PTHR11618, 1 hit |
Pfami | View protein in Pfam PF08271, TF_Zn_Ribbon, 1 hit PF00382, TFIIB, 2 hits |
PRINTSi | PR00685, TIFACTORIIB |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00782, TFIIB, 2 hits PS51134, ZF_TFIIB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TF2B_HUMAN | |
Accessioni | Q00403Primary (citable) accession number: Q00403 Secondary accession number(s): A8K1A7, Q5JS30 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 219 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations