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Protein

Transcription initiation factor IIB

Gene

GTF2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:1876184, PubMed:1946368, PubMed:1517211, PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:7601352, PubMed:9420329, PubMed:12931194, PubMed:27193682). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:9420329, PubMed:16230532, PubMed:7675079, PubMed:10619841). Modulates transcription start site selection (PubMed:10318856). Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194).19 Publications

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.1 Publication

Kineticsi

  1. KM=0.117 mM for acetyl-CoA1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Metal bindingi15ZincCombined sources2 Publications1
    Metal bindingi18Zinc; via tele nitrogenCombined sources2 Publications1
    Metal bindingi34ZincCombined sources2 Publications1
    Metal bindingi37ZincCombined sources2 Publications1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri11 – 42TFIIB-typePROSITE-ProRule annotationAdd BLAST32

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionAcyltransferase, DNA-binding, Transferase
    Biological processHost-virus interaction, Transcription, Transcription regulation
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiR-HSA-167161 HIV Transcription Initiation
    R-HSA-167162 RNA Polymerase II HIV Promoter Escape
    R-HSA-167172 Transcription of the HIV genome
    R-HSA-674695 RNA Polymerase II Pre-transcription Events
    R-HSA-6807505 RNA polymerase II transcribes snRNA genes
    R-HSA-73776 RNA Polymerase II Promoter Escape
    R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    R-HSA-75953 RNA Polymerase II Transcription Initiation
    R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
    SIGNORiQ00403

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor IIB1 Publication (EC:2.3.1.481 Publication)
    Alternative name(s):
    General transcription factor TFIIB1 Publication
    S300-II1 Publication
    Gene namesi
    Name:GTF2B
    Synonyms:TF2B, TFIIB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 1

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000137947.11
    HGNCiHGNC:4648 GTF2B
    MIMi189963 gene
    neXtProtiNX_Q00403

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi37C → S: Does not inhibit interaction with TBP. Inhibits the recruitment of RNA polymerase II into the initiation complex. 1 Publication1
    Mutagenesisi51 – 56EWRTFS → AWRTFA: Partial loss of HIV-1 Vpr binding. 1 Publication6
    Mutagenesisi51E → R, A or D: Defects in transcription start site selection. Supports a level of transcription equivalent to wild-type. 1 Publication1
    Mutagenesisi52W → A: Partial loss of HIV-1 Vpr binding. 1 Publication1
    Mutagenesisi53 – 54RT → AA: Partial loss of HIV-1 Vpr binding. 1 Publication2
    Mutagenesisi55F → A: Partial loss of HIV-1 Vpr binding. 1 Publication1
    Mutagenesisi66R → A, E or K: Defects in transcription start site selection. Supports a level of transcription equivalent to wild-type. 1 Publication1
    Mutagenesisi153G → Q: Decreases BREd-dependent pre-initiation complex formation. 1 Publication1
    Mutagenesisi185R → E: Reduces interaction with SSU72; when associated with E-193 or E-200. Inhibits interaction with VP16; when associated with E-193. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription; when associated with E-193. 2 Publications1
    Mutagenesisi185R → L: Reduces interaction with VP16; when associated with L-189. 1 Publication1
    Mutagenesisi189K → E: Inhibits interaction with SSU72; when associated with E-193. Reduces interaction with SSU72; when associated with E-200. Inhibits interaction with VP16; when associated with E-200. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription; when associated with E-200. 2 Publications1
    Mutagenesisi189K → L: Reduces interaction with VP16; when associated with L-185. 1 Publication1
    Mutagenesisi193R → E: Inhibits interaction with SSU72; when associated with E-185 or E-189. Inhibits interaction with VP16; when associated with E-185. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription; when associated with E-185. 2 Publications1
    Mutagenesisi196K → L: Reduces interaction with VP16; when associated with L-200. 1 Publication1
    Mutagenesisi200 – 208KALETSVDL → GSGS: Reduces the formation of the TATA box-bound TBP ternary complex. 1 Publication9
    Mutagenesisi200K → E: Reduces interaction with SSU72; when associated with E-185 or E-189. Inhibits interaction with VP16; when associated with E-189. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription; when associated with E-189. 2 Publications1
    Mutagenesisi200K → KGSGS: Reduces the formation of the TATA box-bound TBP ternary complex. 1 Publication1
    Mutagenesisi200K → L: Reduces interaction with VP16; when associated with L-196. 1 Publication1
    Mutagenesisi208L → LGSGS: Does not inhibit the formation of the TATA box-bound TBP ternary complex. 1 Publication1
    Mutagenesisi238K → A: Abolishes autoacetylation, represses transcription activity, does not inhibit its association with chromatin to promoter-specific regions and decreases the association of GTF2F1 with chromatin to promoter-specific regions. 1 Publication1
    Mutagenesisi247G → V: Inhibits interaction with TBP. 1 Publication1
    Mutagenesisi283V → A: Reduces DNA-binding. 1 Publication1
    Mutagenesisi286R → A: Reduces DNA-binding. 1 Publication1
    Mutagenesisi286R → E: Inhibits interaction with RNA polymerase II; when associated with E-290 and E-295. 1 Publication1
    Mutagenesisi290R → E: Inhibits interaction with RNA polymerase II; when associated with E-286 and E-295. 1 Publication1
    Mutagenesisi295R → E: Inhibits interaction with RNA polymerase II; when associated with E-286 and E-290. 1 Publication1

    Organism-specific databases

    DisGeNETi2959
    OpenTargetsiENSG00000137947
    PharmGKBiPA29035

    Polymorphism and mutation databases

    BioMutaiGTF2B
    DMDMi135629

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001192931 – 316Transcription initiation factor IIBAdd BLAST316

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei70PhosphoserineCombined sources1
    Modified residuei76PhosphoserineCombined sources1
    Modified residuei92PhosphoserineCombined sources1
    Modified residuei238N6-acetyllysine; by autocatalysis1 Publication1

    Post-translational modificationi

    Acetylated (PubMed:24441171). Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation (PubMed:12931194).2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    EPDiQ00403
    MaxQBiQ00403
    PaxDbiQ00403
    PeptideAtlasiQ00403
    PRIDEiQ00403
    ProteomicsDBi57846

    PTM databases

    iPTMnetiQ00403
    PhosphoSitePlusiQ00403

    Miscellaneous databases

    PMAP-CutDBiQ00403

    Expressioni

    Tissue specificityi

    Expressed in the inner cell mass forming the embryoblast (PubMed:24441171). Not detected in cells from the outer thin layer trophoblast (at protein level) (PubMed:24441171).1 Publication

    Gene expression databases

    BgeeiENSG00000137947 Expressed in 224 organ(s), highest expression level in oocyte
    CleanExiHS_GTF2B
    ExpressionAtlasiQ00403 baseline and differential
    GenevisibleiQ00403 HS

    Organism-specific databases

    HPAiHPA061626

    Interactioni

    Subunit structurei

    Found in a ternary complex with TATA box-bound TBP (PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:10619841, PubMed:29158257). Part of a TFIID-containing RNA polymerase II pre-initiation complex (PIC) that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27193682). Associates with TFIID-TFIIA (DA complex) to form TFIID-TFIIA-TFIIB (DAB complex), which is then recognized by RNA polymerase II (Pol II) (PubMed:1876184, PubMed:2247058). Found in a RNA polymerase II initiation complex (PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8516312, PubMed:7601352). Interacts (via C-terminus) with TBP; this interaction with TATA box-bound TBP guides Pol II into the PIC (PubMed:8504927, PubMed:10619841). Interacts (via N-terminus) with Pol II (PubMed:8504927, PubMed:8413225). Interacts (via C-terminus) with SSU72; this interaction is inhibited by SYMPK (PubMed:29158257). Interacts with NR2F1; this interaction is direct (PubMed:1517211). Interacts with PGR (PubMed:1517211). Interacts with ESR1 (PubMed:1517211). Interacts with GTF2F1 (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2 (PubMed:8662660, PubMed:12931194). Interacts with GTF2F2 (via N-terminus); this interaction is inhibited in presence of GTF2F1 (PubMed:8504927, PubMed:8662660). Interacts with the transcription elongation factor TCEA2 (PubMed:8566795). Interacts with HSF1 (via transactivation domain) (PubMed:11005381). Interacts with GPBP1 (By similarity).By similarity18 Publications
    (Microbial infection) Interacts with HIV-1 Vpr.1 Publication
    (Microbial infection) Interacts with Epstein-Barr virus EBNA2.1 Publication
    (Microbial infection) Interacts with Herpes simplex virus 1 protein ICP4.1 Publication
    (Microbial infection) Interacts (via C-terminus) with the Herpes simplex virus activator VP16; this interaction stimulates RNA Pol II transcription by increasing the extent of pre-initiation complex assembly.2 Publications

    Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi109214, 90 interactors
    CORUMiQ00403
    DIPiDIP-1077N
    IntActiQ00403, 37 interactors
    MINTiQ00403
    STRINGi9606.ENSP00000359531

    Structurei

    Secondary structure

    1316
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliQ00403
    SMRiQ00403
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ00403

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Repeati124 – 2001Add BLAST77
    Repeati218 – 2942Add BLAST77

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni189 – 193Core promoter DNA-binding1 Publication5
    Regioni244 – 316Necessary for TATA box-bound TBP complex formation2 PublicationsAdd BLAST73
    Regioni249 – 252Core promoter DNA-binding1 Publication4
    Regioni283 – 286Core promoter DNA-binding2 Publications4

    Domaini

    The TFIIB-type zinc-binding domain is necessary for the interaction and recruitment of RNA polymerase II to the core promoter, the formation of a fully competent pre-initiation complex (PIC) assembly and basal transcription initiation (PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:8413225). The C-terminus is necessary and sufficient for interaction with the TATA box-bound TBP complex and for the formation of PIC (PubMed:8515820, PubMed:8516311, PubMed:8413225).4 Publications

    Sequence similaritiesi

    Belongs to the TFIIB family.Curated

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri11 – 42TFIIB-typePROSITE-ProRule annotationAdd BLAST32

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiKOG1597 Eukaryota
    COG1405 LUCA
    GeneTreeiENSGT00390000006671
    HOGENOMiHOG000108634
    HOVERGENiHBG017914
    InParanoidiQ00403
    KOiK03124
    OMAiNLGLPNM
    OrthoDBiEOG091G0E7S
    PhylomeDBiQ00403
    TreeFamiTF105953

    Family and domain databases

    CDDicd00043 CYCLIN, 2 hits
    InterProiView protein in InterPro
    IPR013763 Cyclin-like
    IPR036915 Cyclin-like_sf
    IPR000812 TFIIB
    IPR023486 TFIIB_CS
    IPR013150 TFIIB_cyclin
    IPR013137 Znf_TFIIB
    PANTHERiPTHR11618 PTHR11618, 1 hit
    PfamiView protein in Pfam
    PF08271 TF_Zn_Ribbon, 1 hit
    PF00382 TFIIB, 2 hits
    PRINTSiPR00685 TIFACTORIIB
    SMARTiView protein in SMART
    SM00385 CYCLIN, 2 hits
    SUPFAMiSSF47954 SSF47954, 2 hits
    PROSITEiView protein in PROSITE
    PS00782 TFIIB, 2 hits
    PS51134 ZF_TFIIB, 1 hit

    Sequence (1+)i

    Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q00403-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS
    60 70 80 90 100
    EWRTFSNDKA TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK
    110 120 130 140 150
    YQNRRTMSSS DRAMMNAFKE ITTMADRINL PRNIVDRTNN LFKQVYEQKS
    160 170 180 190 200
    LKGRANDAIA SACLYIACRQ EGVPRTFKEI CAVSRISKKE IGRCFKLILK
    210 220 230 240 250
    ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV ELDLVPGRSP
    260 270 280 290 300
    ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF
    310
    PTDFKFDTPV DKLPQL
    Length:316
    Mass (Da):34,833
    Last modified:December 1, 1992 - v1
    Checksum:i9CC7E102526C2722
    GO

    Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B1APE1B1APE1_HUMAN
    Transcription initiation factor IIB
    GTF2B
    224Annotation score:
    B1APE2B1APE2_HUMAN
    Transcription initiation factor IIB
    GTF2B
    231Annotation score:

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_01197719P → S. Corresponds to variant dbSNP:rs1804499Ensembl.1
    Natural variantiVAR_035722132R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs144944840Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X59268 mRNA Translation: CAA41958.1
    M76766 mRNA Translation: AAA61149.1
    AK289822 mRNA Translation: BAF82511.1
    AB451296 mRNA Translation: BAG70110.1
    AL445991 Genomic DNA No translation available.
    BC020597 mRNA Translation: AAH20597.1
    S44184 mRNA Translation: AAB23144.1
    CCDSiCCDS715.1
    PIRiS17654 TWHU2B
    RefSeqiNP_001505.1, NM_001514.5
    UniGeneiHs.481852

    Genome annotation databases

    EnsembliENST00000370500; ENSP00000359531; ENSG00000137947
    GeneIDi2959
    KEGGihsa:2959
    UCSCiuc001dmo.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X59268 mRNA Translation: CAA41958.1
    M76766 mRNA Translation: AAA61149.1
    AK289822 mRNA Translation: BAF82511.1
    AB451296 mRNA Translation: BAG70110.1
    AL445991 Genomic DNA No translation available.
    BC020597 mRNA Translation: AAH20597.1
    S44184 mRNA Translation: AAB23144.1
    CCDSiCCDS715.1
    PIRiS17654 TWHU2B
    RefSeqiNP_001505.1, NM_001514.5
    UniGeneiHs.481852

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1C9BX-ray2.65A/E/I/M/Q110-316[»]
    1DL6NMR-A2-59[»]
    1RLYNMR-A1-60[»]
    1RO4NMR-A1-60[»]
    1TFBNMR-A112-316[»]
    1VOLX-ray2.70A113-316[»]
    2PHGNMR-A112-316[»]
    5IY6electron microscopy7.20M1-316[»]
    5IY7electron microscopy8.60M1-316[»]
    5IY8electron microscopy7.90M1-316[»]
    5IY9electron microscopy6.30M1-316[»]
    5IYAelectron microscopy5.40M1-316[»]
    5IYBelectron microscopy3.90M1-316[»]
    5IYCelectron microscopy3.90M1-316[»]
    5IYDelectron microscopy3.90M1-316[»]
    5WH1X-ray3.39A/B/C/D107-316[»]
    ProteinModelPortaliQ00403
    SMRiQ00403
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi109214, 90 interactors
    CORUMiQ00403
    DIPiDIP-1077N
    IntActiQ00403, 37 interactors
    MINTiQ00403
    STRINGi9606.ENSP00000359531

    PTM databases

    iPTMnetiQ00403
    PhosphoSitePlusiQ00403

    Polymorphism and mutation databases

    BioMutaiGTF2B
    DMDMi135629

    Proteomic databases

    EPDiQ00403
    MaxQBiQ00403
    PaxDbiQ00403
    PeptideAtlasiQ00403
    PRIDEiQ00403
    ProteomicsDBi57846

    Protocols and materials databases

    DNASUi2959
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000370500; ENSP00000359531; ENSG00000137947
    GeneIDi2959
    KEGGihsa:2959
    UCSCiuc001dmo.5 human

    Organism-specific databases

    CTDi2959
    DisGeNETi2959
    EuPathDBiHostDB:ENSG00000137947.11
    GeneCardsiGTF2B
    HGNCiHGNC:4648 GTF2B
    HPAiHPA061626
    MIMi189963 gene
    neXtProtiNX_Q00403
    OpenTargetsiENSG00000137947
    PharmGKBiPA29035
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1597 Eukaryota
    COG1405 LUCA
    GeneTreeiENSGT00390000006671
    HOGENOMiHOG000108634
    HOVERGENiHBG017914
    InParanoidiQ00403
    KOiK03124
    OMAiNLGLPNM
    OrthoDBiEOG091G0E7S
    PhylomeDBiQ00403
    TreeFamiTF105953

    Enzyme and pathway databases

    ReactomeiR-HSA-167161 HIV Transcription Initiation
    R-HSA-167162 RNA Polymerase II HIV Promoter Escape
    R-HSA-167172 Transcription of the HIV genome
    R-HSA-674695 RNA Polymerase II Pre-transcription Events
    R-HSA-6807505 RNA polymerase II transcribes snRNA genes
    R-HSA-73776 RNA Polymerase II Promoter Escape
    R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    R-HSA-75953 RNA Polymerase II Transcription Initiation
    R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
    SIGNORiQ00403

    Miscellaneous databases

    ChiTaRSiGTF2B human
    EvolutionaryTraceiQ00403
    GeneWikiiTranscription_factor_II_B
    GenomeRNAii2959
    PMAP-CutDBiQ00403
    PROiPR:Q00403
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000137947 Expressed in 224 organ(s), highest expression level in oocyte
    CleanExiHS_GTF2B
    ExpressionAtlasiQ00403 baseline and differential
    GenevisibleiQ00403 HS

    Family and domain databases

    CDDicd00043 CYCLIN, 2 hits
    InterProiView protein in InterPro
    IPR013763 Cyclin-like
    IPR036915 Cyclin-like_sf
    IPR000812 TFIIB
    IPR023486 TFIIB_CS
    IPR013150 TFIIB_cyclin
    IPR013137 Znf_TFIIB
    PANTHERiPTHR11618 PTHR11618, 1 hit
    PfamiView protein in Pfam
    PF08271 TF_Zn_Ribbon, 1 hit
    PF00382 TFIIB, 2 hits
    PRINTSiPR00685 TIFACTORIIB
    SMARTiView protein in SMART
    SM00385 CYCLIN, 2 hits
    SUPFAMiSSF47954 SSF47954, 2 hits
    PROSITEiView protein in PROSITE
    PS00782 TFIIB, 2 hits
    PS51134 ZF_TFIIB, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiTF2B_HUMAN
    AccessioniPrimary (citable) accession number: Q00403
    Secondary accession number(s): A8K1A7, Q5JS30
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: November 7, 2018
    This is version 204 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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