UniProtKB - Q00401 (HMH2_GIRTI)
Protein
Homeobox protein DTH-2
Gene
DTH-2
Organism
Girardia tigrina (Planarian) (Dugesia tigrina)
Status
Functioni
This protein might be involved in determination and/or differentiation of nerve cells in the continuous replacement of neurons in the cephalic region.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 133 – 192 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein DTH-2 |
Gene namesi | Name:DTH-2 |
Organismi | Girardia tigrina (Planarian) (Dugesia tigrina) |
Taxonomic identifieri | 6162 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Rhabditophora › Seriata › Tricladida › Continenticola › Geoplanoidea › Dugesiidae › Girardia |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049065 | 1 – 363 | Homeobox protein DTH-2Add BLAST | 363 |
Expressioni
Tissue specificityi
Intestine and unidentified peripheral parenchymal cells. Slightly higher levels in the cephalic region compared to other body regions.
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 29 – 42 | Ser-richAdd BLAST | 14 | |
Compositional biasi | 62 – 94 | Asn/Ser-richAdd BLAST | 33 | |
Compositional biasi | 319 – 331 | Ser-richAdd BLAST | 13 | |
Compositional biasi | 348 – 363 | Asn/Ser-richAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the NK-2 homeobox family.Curated
Keywords - Domaini
HomeoboxFamily and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q00401-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGIPGLAGM SSMSPYSAYA ALTQHTGVSS GSSPFGSQYC SSVNDFNPYS
60 70 80 90 100
DPRGSNTWYG MAASANASND PRMTMSRLMG SAAAAASSSM SAYSGIPTNF
110 120 130 140 150
HQGMHSAMGM ASLGAATYDH QKAAMQFNNM SQRRKRRILF SQAQIYELER
160 170 180 190 200
RFKQQKYLSA PEREHLANLI NLTPTQVKIW FQNHRYKCKR SQKDKEKEQQ
210 220 230 240 250
KEKSYHLKKN IVDDKERSPN KQICNASSSD RSTPEEPVAK AKESGLDFSN
260 270 280 290 300
HKIDNLNLKM EADLEPKSSL YSIIPPYLTN SYAQQTQSEA QTSPIINNVL
310 320 330 340 350
GSNLFPERKS TPTMGPLTSY SFGQSMDSIS SFYSPDFSLY NCAHPYMAAS
360
SSYFMNAASR PWN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56500 mRNA Translation: CAA39855.1 X69202 Genomic DNA Translation: CAA49140.1 |
PIRi | S33702 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56500 mRNA Translation: CAA39855.1 X69202 Genomic DNA Translation: CAA49140.1 |
PIRi | S33702 |
3D structure databases
SMRi | Q00401 |
ModBasei | Search... |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HMH2_GIRTI | |
Accessioni | Q00401Primary (citable) accession number: Q00401 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | October 7, 2020 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |