Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vigilin

Gene

HDLBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • lipid binding Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-HSA-8964011 HDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Vigilin
Alternative name(s):
High density lipoprotein-binding protein
Short name:
HDL-binding protein
Gene namesi
Name:HDLBP
Synonyms:HBP, VGL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115677.16
HGNCiHGNC:4857 HDLBP
MIMi142695 gene
neXtProtiNX_Q00341

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, HDL, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3069
PharmGKBiPA29235

Polymorphism and mutation databases

BioMutaiHDLBP
DMDMi218511884

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000501312 – 1268VigilinAdd BLAST1267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei8PhosphothreonineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei35PhosphoserineBy similarity1
Modified residuei295PhosphothreonineSequence analysis1
Modified residuei296PhosphothreonineSequence analysis1
Modified residuei317PhosphoserineCombined sources1
Modified residuei437PhosphotyrosineCombined sources1
Modified residuei645PhosphoserineBy similarity1
Modified residuei991N6-acetyllysineBy similarity1
Modified residuei1247PhosphoserineCombined sources1
Modified residuei1252PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ00341
MaxQBiQ00341
PaxDbiQ00341
PeptideAtlasiQ00341
PRIDEiQ00341
ProteomicsDBi57845

PTM databases

iPTMnetiQ00341
PhosphoSitePlusiQ00341
SwissPalmiQ00341

Expressioni

Gene expression databases

BgeeiENSG00000115677 Expressed in 239 organ(s), highest expression level in testis
CleanExiHS_HDLBP
ExpressionAtlasiQ00341 baseline and differential
GenevisibleiQ00341 HS

Organism-specific databases

HPAiCAB026457
HPA004189

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTCFP497114EBI-1049478,EBI-932887

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109319, 93 interactors
CORUMiQ00341
IntActiQ00341, 36 interactors
MINTiQ00341
STRINGi9606.ENSP00000312042

Structurei

Secondary structure

11268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ00341
SMRiQ00341
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00341

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 229KH 1PROSITE-ProRule annotationAdd BLAST72
Domaini230 – 302KH 2PROSITE-ProRule annotationAdd BLAST73
Domaini303 – 371KH 3PROSITE-ProRule annotationAdd BLAST69
Domaini372 – 442KH 4PROSITE-ProRule annotationAdd BLAST71
Domaini443 – 514KH 5PROSITE-ProRule annotationAdd BLAST72
Domaini515 – 588KH 6PROSITE-ProRule annotationAdd BLAST74
Domaini589 – 660KH 7PROSITE-ProRule annotationAdd BLAST72
Domaini661 – 734KH 8PROSITE-ProRule annotationAdd BLAST74
Domaini735 – 807KH 9PROSITE-ProRule annotationAdd BLAST73
Domaini808 – 880KH 10PROSITE-ProRule annotationAdd BLAST73
Domaini881 – 979KH 11PROSITE-ProRule annotationAdd BLAST99
Domaini980 – 1059KH 12PROSITE-ProRule annotationAdd BLAST80
Domaini1060 – 1134KH 13PROSITE-ProRule annotationAdd BLAST75
Domaini1135 – 1209KH 14PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2208 Eukaryota
ENOG410XQFV LUCA
HOGENOMiHOG000007687
HOVERGENiHBG054107
InParanoidiQ00341
PhylomeDBiQ00341
TreeFamiTF323767

Family and domain databases

Gene3Di3.30.1370.10, 14 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 14 hits
SMARTiView protein in SMART
SM00322 KH, 14 hits
SUPFAMiSSF54791 SSF54791, 12 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 14 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 23 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00341-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEESDPPTY KDAFPPLPEK
60 70 80 90 100
AACLESAQEP SGAWGNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ
110 120 130 140 150
AKICLEIMQR TGAHLELSLA KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ
160 170 180 190 200
ASATVAIPKE HHRFVIGKNG EKLQDLELKT ATKIQIPRPD DPSNQIKITG
210 220 230 240 250
TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP YNRLVGEIMQ
260 270 280 290 300
ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV
310 320 330 340 350
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL
360 370 380 390 400
GQALTEVYAK ANSFTVSSVA APSWLHRFII GKKGQNLAKI TQQMPKVHIE
410 420 430 440 450
FTEGEDKITL EGPTEDVNVA QEQIEGMVKD LINRMDYVEI NIDHKFHRHL
460 470 480 490 500
IGKSGANINR IKDQYKVSVR IPPDSEKSNL IRIEGDPQGV QQAKRELLEL
510 520 530 540 550
ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV IINFPDPAQK
560 570 580 590 600
SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG
610 620 630 640 650
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL
660 670 680 690 700
ANIAEVEVSI PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV
710 720 730 740 750
VIRGPSSDVE KAKKQLLHLA EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI
760 770 780 790 800
RKVRDSTGAR VIFPAAEDKD QDLITIIGKE DAVREAQKEL EALIQNLDNV
810 820 830 840 850
VEDSMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS GTQSDKVTLK
860 870 880 890 900
GAKDCVEAAK KRIQEIIEDL EAQVTLECAI PQKFHRSVMG PKGSRIQQIT
910 920 930 940 950
RDFSVQIKFP DREENAVHST EPVVQENGDE AGEGREAKDC DPGSPRRCDI
960 970 980 990 1000
IIISGRKEKC EAAKEALEAL VPVTIEVEVP FDLHRYVIGQ KGSGIRKMMD
1010 1020 1030 1040 1050
EFEVNIHVPA PELQSDIIAI TGLAANLDRA KAGLLERVKE LQAEQEDRAL
1060 1070 1080 1090 1100
RSFKLSVTVD PKYHPKIIGR KGAVITQIRL EHDVNIQFPD KDDGNQPQDQ
1110 1120 1130 1140 1150
ITITGYEKNT EAARDAILRI VGELEQMVSE DVPLDHRVHA RIIGARGKAI
1160 1170 1180 1190 1200
RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD
1210 1220 1230 1240 1250
VVDSEALQVY MKPPAHEEAK APSRGFVVRD APWTASSSEK APDMSSSEEF
1260
PSFGAQVAPK TLPWGPKR
Length:1,268
Mass (Da):141,456
Last modified:December 16, 2008 - v2
Checksum:i530C61A3CA9239CD
GO
Isoform 2 (identifier: Q00341-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTM
     291-359: Missing.

Note: No experimental confirmation available.
Show »
Length:1,235
Mass (Da):137,987
Checksum:i9A49873E7937B9D4
GO

Computationally mapped potential isoform sequencesi

There are 23 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024R4E5A0A024R4E5_HUMAN
High density lipoprotein binding pr...
HDLBP hCG_33048
1,268Annotation score:
C9JIZ1C9JIZ1_HUMAN
Vigilin
HDLBP
224Annotation score:
C9J5E5C9J5E5_HUMAN
Vigilin
HDLBP
221Annotation score:
H7C0A4H7C0A4_HUMAN
Vigilin
HDLBP
332Annotation score:
H7C2D1H7C2D1_HUMAN
Vigilin
HDLBP
308Annotation score:
H0Y394H0Y394_HUMAN
Vigilin
HDLBP
973Annotation score:
H7C3D0H7C3D0_HUMAN
Vigilin
HDLBP
126Annotation score:
H7BZC3H7BZC3_HUMAN
Vigilin
HDLBP
267Annotation score:
C9JZI8C9JZI8_HUMAN
Vigilin
HDLBP
164Annotation score:
C9JES8C9JES8_HUMAN
Vigilin
HDLBP
147Annotation score:
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04797661S → ACombined sources3 PublicationsCorresponds to variant dbSNP:rs11891776Ensembl.1
Natural variantiVAR_055981229V → I. Corresponds to variant dbSNP:rs7572799Ensembl.1
Natural variantiVAR_024511418N → S. Corresponds to variant dbSNP:rs7578199Ensembl.1
Natural variantiVAR_036052568K → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036053939D → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0292791264W → L. Corresponds to variant dbSNP:rs12281Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449241M → MHLAERDRWLFVATVMMHFV SIKSGFPGLCVGVRSTM in isoform 2. 1 Publication1
Alternative sequenceiVSP_044925291 – 359Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64098 mRNA Translation: AAA35962.1
AK300312 mRNA Translation: BAG62064.1
AC104841 Genomic DNA Translation: AAY14717.1
BC001179 mRNA Translation: AAH01179.1
CCDSiCCDS2547.1 [Q00341-1]
CCDS58760.1 [Q00341-2]
PIRiA44125
RefSeqiNP_001230829.1, NM_001243900.2
NP_001307894.1, NM_001320965.1
NP_001307895.1, NM_001320966.1
NP_005327.1, NM_005336.5
NP_976221.1, NM_203346.4
XP_005247059.2, XM_005247002.3
XP_005247060.2, XM_005247003.4
XP_006712538.1, XM_006712475.3
XP_011509360.1, XM_011511058.2
XP_011509362.1, XM_011511060.2
XP_016859429.1, XM_017003940.1
UniGeneiHs.471851
Hs.732361

Genome annotation databases

EnsembliENST00000427183; ENSP00000399139; ENSG00000115677
GeneIDi3069
KEGGihsa:3069
UCSCiuc021vzg.1 human [Q00341-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64098 mRNA Translation: AAA35962.1
AK300312 mRNA Translation: BAG62064.1
AC104841 Genomic DNA Translation: AAY14717.1
BC001179 mRNA Translation: AAH01179.1
CCDSiCCDS2547.1 [Q00341-1]
CCDS58760.1 [Q00341-2]
PIRiA44125
RefSeqiNP_001230829.1, NM_001243900.2
NP_001307894.1, NM_001320965.1
NP_001307895.1, NM_001320966.1
NP_005327.1, NM_005336.5
NP_976221.1, NM_203346.4
XP_005247059.2, XM_005247002.3
XP_005247060.2, XM_005247003.4
XP_006712538.1, XM_006712475.3
XP_011509360.1, XM_011511058.2
XP_011509362.1, XM_011511060.2
XP_016859429.1, XM_017003940.1
UniGeneiHs.471851
Hs.732361

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VIGNMR-A432-502[»]
1VIHNMR-A432-502[»]
2CTENMR-A142-222[»]
2CTFNMR-A346-434[»]
2CTJNMR-A645-726[»]
2CTKNMR-A964-1054[»]
2CTLNMR-A1044-1127[»]
2CTMNMR-A1119-1200[»]
ProteinModelPortaliQ00341
SMRiQ00341
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109319, 93 interactors
CORUMiQ00341
IntActiQ00341, 36 interactors
MINTiQ00341
STRINGi9606.ENSP00000312042

PTM databases

iPTMnetiQ00341
PhosphoSitePlusiQ00341
SwissPalmiQ00341

Polymorphism and mutation databases

BioMutaiHDLBP
DMDMi218511884

Proteomic databases

EPDiQ00341
MaxQBiQ00341
PaxDbiQ00341
PeptideAtlasiQ00341
PRIDEiQ00341
ProteomicsDBi57845

Protocols and materials databases

DNASUi3069
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427183; ENSP00000399139; ENSG00000115677
GeneIDi3069
KEGGihsa:3069
UCSCiuc021vzg.1 human [Q00341-1]

Organism-specific databases

CTDi3069
DisGeNETi3069
EuPathDBiHostDB:ENSG00000115677.16
GeneCardsiHDLBP
HGNCiHGNC:4857 HDLBP
HPAiCAB026457
HPA004189
MIMi142695 gene
neXtProtiNX_Q00341
PharmGKBiPA29235
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2208 Eukaryota
ENOG410XQFV LUCA
HOGENOMiHOG000007687
HOVERGENiHBG054107
InParanoidiQ00341
PhylomeDBiQ00341
TreeFamiTF323767

Enzyme and pathway databases

ReactomeiR-HSA-8964011 HDL clearance

Miscellaneous databases

ChiTaRSiHDLBP human
EvolutionaryTraceiQ00341
GeneWikiiHDLBP
GenomeRNAii3069
PROiPR:Q00341
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115677 Expressed in 239 organ(s), highest expression level in testis
CleanExiHS_HDLBP
ExpressionAtlasiQ00341 baseline and differential
GenevisibleiQ00341 HS

Family and domain databases

Gene3Di3.30.1370.10, 14 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 14 hits
SMARTiView protein in SMART
SM00322 KH, 14 hits
SUPFAMiSSF54791 SSF54791, 12 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 14 hits
ProtoNetiSearch...

Entry informationi

Entry nameiVIGLN_HUMAN
AccessioniPrimary (citable) accession number: Q00341
Secondary accession number(s): B4DTQ2
, E7EM71, Q53QU2, Q9UCY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again