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Entry version 188 (08 May 2019)
Sequence version 2 (16 Dec 2008)
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Protein

Vigilin

Gene

HDLBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8964011 HDL clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vigilin
Alternative name(s):
High density lipoprotein-binding protein
Short name:
HDL-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDLBP
Synonyms:HBP, VGL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4857 HDLBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142695 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q00341

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, HDL, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3069

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29235

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HDLBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
218511884

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000501312 – 1268VigilinAdd BLAST1267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei8PhosphothreonineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei35PhosphoserineBy similarity1
Modified residuei295PhosphothreonineSequence analysis1
Modified residuei296PhosphothreonineSequence analysis1
Modified residuei317PhosphoserineCombined sources1
Modified residuei437PhosphotyrosineCombined sources1
Modified residuei645PhosphoserineBy similarity1
Modified residuei991N6-acetyllysineBy similarity1
Modified residuei1247PhosphoserineCombined sources1
Modified residuei1252PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q00341

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q00341

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q00341

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q00341

PeptideAtlas

More...
PeptideAtlasi
Q00341

PRoteomics IDEntifications database

More...
PRIDEi
Q00341

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57845

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q00341

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q00341

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q00341

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115677 Expressed in 239 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q00341 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q00341 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026457
HPA004189

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CTCFP497114EBI-1049478,EBI-932887

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109319, 102 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q00341

Protein interaction database and analysis system

More...
IntActi
Q00341, 44 interactors

Molecular INTeraction database

More...
MINTi
Q00341

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375836

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VIGNMR-A432-502[»]
1VIHNMR-A432-502[»]
2CTENMR-A142-222[»]
2CTFNMR-A346-434[»]
2CTJNMR-A645-726[»]
2CTKNMR-A964-1054[»]
2CTLNMR-A1044-1127[»]
2CTMNMR-A1119-1200[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q00341

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q00341

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini158 – 229KH 1PROSITE-ProRule annotationAdd BLAST72
Domaini230 – 302KH 2PROSITE-ProRule annotationAdd BLAST73
Domaini303 – 371KH 3PROSITE-ProRule annotationAdd BLAST69
Domaini372 – 442KH 4PROSITE-ProRule annotationAdd BLAST71
Domaini443 – 514KH 5PROSITE-ProRule annotationAdd BLAST72
Domaini515 – 588KH 6PROSITE-ProRule annotationAdd BLAST74
Domaini589 – 660KH 7PROSITE-ProRule annotationAdd BLAST72
Domaini661 – 734KH 8PROSITE-ProRule annotationAdd BLAST74
Domaini735 – 807KH 9PROSITE-ProRule annotationAdd BLAST73
Domaini808 – 880KH 10PROSITE-ProRule annotationAdd BLAST73
Domaini881 – 979KH 11PROSITE-ProRule annotationAdd BLAST99
Domaini980 – 1059KH 12PROSITE-ProRule annotationAdd BLAST80
Domaini1060 – 1134KH 13PROSITE-ProRule annotationAdd BLAST75
Domaini1135 – 1209KH 14PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2208 Eukaryota
ENOG410XQFV LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007687

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00341

Database of Orthologous Groups

More...
OrthoDBi
248989at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q00341

TreeFam database of animal gene trees

More...
TreeFami
TF323767

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.10, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00013 KH_1, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00322 KH, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54791 SSF54791, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50084 KH_TYPE_1, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 23 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00341-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEESDPPTY KDAFPPLPEK
60 70 80 90 100
AACLESAQEP SGAWGNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ
110 120 130 140 150
AKICLEIMQR TGAHLELSLA KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ
160 170 180 190 200
ASATVAIPKE HHRFVIGKNG EKLQDLELKT ATKIQIPRPD DPSNQIKITG
210 220 230 240 250
TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP YNRLVGEIMQ
260 270 280 290 300
ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV
310 320 330 340 350
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL
360 370 380 390 400
GQALTEVYAK ANSFTVSSVA APSWLHRFII GKKGQNLAKI TQQMPKVHIE
410 420 430 440 450
FTEGEDKITL EGPTEDVNVA QEQIEGMVKD LINRMDYVEI NIDHKFHRHL
460 470 480 490 500
IGKSGANINR IKDQYKVSVR IPPDSEKSNL IRIEGDPQGV QQAKRELLEL
510 520 530 540 550
ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV IINFPDPAQK
560 570 580 590 600
SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG
610 620 630 640 650
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL
660 670 680 690 700
ANIAEVEVSI PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV
710 720 730 740 750
VIRGPSSDVE KAKKQLLHLA EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI
760 770 780 790 800
RKVRDSTGAR VIFPAAEDKD QDLITIIGKE DAVREAQKEL EALIQNLDNV
810 820 830 840 850
VEDSMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS GTQSDKVTLK
860 870 880 890 900
GAKDCVEAAK KRIQEIIEDL EAQVTLECAI PQKFHRSVMG PKGSRIQQIT
910 920 930 940 950
RDFSVQIKFP DREENAVHST EPVVQENGDE AGEGREAKDC DPGSPRRCDI
960 970 980 990 1000
IIISGRKEKC EAAKEALEAL VPVTIEVEVP FDLHRYVIGQ KGSGIRKMMD
1010 1020 1030 1040 1050
EFEVNIHVPA PELQSDIIAI TGLAANLDRA KAGLLERVKE LQAEQEDRAL
1060 1070 1080 1090 1100
RSFKLSVTVD PKYHPKIIGR KGAVITQIRL EHDVNIQFPD KDDGNQPQDQ
1110 1120 1130 1140 1150
ITITGYEKNT EAARDAILRI VGELEQMVSE DVPLDHRVHA RIIGARGKAI
1160 1170 1180 1190 1200
RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD
1210 1220 1230 1240 1250
VVDSEALQVY MKPPAHEEAK APSRGFVVRD APWTASSSEK APDMSSSEEF
1260
PSFGAQVAPK TLPWGPKR
Length:1,268
Mass (Da):141,456
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i530C61A3CA9239CD
GO
Isoform 2 (identifier: Q00341-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTM
     291-359: Missing.

Note: No experimental confirmation available.
Show »
Length:1,235
Mass (Da):137,987
Checksum:i9A49873E7937B9D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 23 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024R4E5A0A024R4E5_HUMAN
High density lipoprotein binding pr...
HDLBP hCG_33048
1,268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIZ1C9JIZ1_HUMAN
Vigilin
HDLBP
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5E5C9J5E5_HUMAN
Vigilin
HDLBP
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0A4H7C0A4_HUMAN
Vigilin
HDLBP
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2D1H7C2D1_HUMAN
Vigilin
HDLBP
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y394H0Y394_HUMAN
Vigilin
HDLBP
973Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3D0H7C3D0_HUMAN
Vigilin
HDLBP
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZC3H7BZC3_HUMAN
Vigilin
HDLBP
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JK79C9JK79_HUMAN
Vigilin
HDLBP
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEJ8C9JEJ8_HUMAN
Vigilin
HDLBP
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04797661S → ACombined sources3 PublicationsCorresponds to variant dbSNP:rs11891776Ensembl.1
Natural variantiVAR_055981229V → I. Corresponds to variant dbSNP:rs7572799Ensembl.1
Natural variantiVAR_024511418N → S. Corresponds to variant dbSNP:rs7578199Ensembl.1
Natural variantiVAR_036052568K → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036053939D → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0292791264W → L. Corresponds to variant dbSNP:rs12281Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449241M → MHLAERDRWLFVATVMMHFV SIKSGFPGLCVGVRSTM in isoform 2. 1 Publication1
Alternative sequenceiVSP_044925291 – 359Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M64098 mRNA Translation: AAA35962.1
AK300312 mRNA Translation: BAG62064.1
AC104841 Genomic DNA Translation: AAY14717.1
BC001179 mRNA Translation: AAH01179.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2547.1 [Q00341-1]
CCDS58760.1 [Q00341-2]

Protein sequence database of the Protein Information Resource

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PIRi
A44125

NCBI Reference Sequences

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RefSeqi
NP_001230829.1, NM_001243900.2
NP_001307894.1, NM_001320965.1
NP_001307895.1, NM_001320966.1
NP_005327.1, NM_005336.5
NP_976221.1, NM_203346.4
XP_005247059.2, XM_005247002.3
XP_005247060.2, XM_005247003.4
XP_006712538.1, XM_006712475.3
XP_011509360.1, XM_011511058.2
XP_011509362.1, XM_011511060.2
XP_016859429.1, XM_017003940.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000427183; ENSP00000399139; ENSG00000115677

Database of genes from NCBI RefSeq genomes

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GeneIDi
3069

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3069

UCSC genome browser

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UCSCi
uc021vzg.1 human [Q00341-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64098 mRNA Translation: AAA35962.1
AK300312 mRNA Translation: BAG62064.1
AC104841 Genomic DNA Translation: AAY14717.1
BC001179 mRNA Translation: AAH01179.1
CCDSiCCDS2547.1 [Q00341-1]
CCDS58760.1 [Q00341-2]
PIRiA44125
RefSeqiNP_001230829.1, NM_001243900.2
NP_001307894.1, NM_001320965.1
NP_001307895.1, NM_001320966.1
NP_005327.1, NM_005336.5
NP_976221.1, NM_203346.4
XP_005247059.2, XM_005247002.3
XP_005247060.2, XM_005247003.4
XP_006712538.1, XM_006712475.3
XP_011509360.1, XM_011511058.2
XP_011509362.1, XM_011511060.2
XP_016859429.1, XM_017003940.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VIGNMR-A432-502[»]
1VIHNMR-A432-502[»]
2CTENMR-A142-222[»]
2CTFNMR-A346-434[»]
2CTJNMR-A645-726[»]
2CTKNMR-A964-1054[»]
2CTLNMR-A1044-1127[»]
2CTMNMR-A1119-1200[»]
SMRiQ00341
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109319, 102 interactors
CORUMiQ00341
IntActiQ00341, 44 interactors
MINTiQ00341
STRINGi9606.ENSP00000375836

PTM databases

iPTMnetiQ00341
PhosphoSitePlusiQ00341
SwissPalmiQ00341

Polymorphism and mutation databases

BioMutaiHDLBP
DMDMi218511884

Proteomic databases

EPDiQ00341
jPOSTiQ00341
MaxQBiQ00341
PaxDbiQ00341
PeptideAtlasiQ00341
PRIDEiQ00341
ProteomicsDBi57845

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3069
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427183; ENSP00000399139; ENSG00000115677
GeneIDi3069
KEGGihsa:3069
UCSCiuc021vzg.1 human [Q00341-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3069
DisGeNETi3069

GeneCards: human genes, protein and diseases

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GeneCardsi
HDLBP
HGNCiHGNC:4857 HDLBP
HPAiCAB026457
HPA004189
MIMi142695 gene
neXtProtiNX_Q00341
PharmGKBiPA29235

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2208 Eukaryota
ENOG410XQFV LUCA
HOGENOMiHOG000007687
InParanoidiQ00341
OrthoDBi248989at2759
PhylomeDBiQ00341
TreeFamiTF323767

Enzyme and pathway databases

ReactomeiR-HSA-8964011 HDL clearance

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HDLBP human
EvolutionaryTraceiQ00341

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HDLBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3069

Protein Ontology

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PROi
PR:Q00341

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115677 Expressed in 239 organ(s), highest expression level in testis
ExpressionAtlasiQ00341 baseline and differential
GenevisibleiQ00341 HS

Family and domain databases

Gene3Di3.30.1370.10, 14 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 14 hits
SMARTiView protein in SMART
SM00322 KH, 14 hits
SUPFAMiSSF54791 SSF54791, 12 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVIGLN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00341
Secondary accession number(s): B4DTQ2
, E7EM71, Q53QU2, Q9UCY3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 16, 2008
Last modified: May 8, 2019
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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