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Protein

CCAAT/enhancer-binding protein delta

Gene

Cebpd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:7594592, PubMed:19641492). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity).By similarity2 Publications

GO - Molecular functioni

  • DNA binding Source: MGI
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  • fat cell differentiation Source: MGI
  • hematopoietic progenitor cell differentiation Source: MGI
  • inner ear development Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein delta
Short name:
C/EBP delta
Alternative name(s):
C/EBP-related protein 31 Publication
Gene namesi
Name:Cebpd
Synonyms:Crp31 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:103573 Cebpd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000766222 – 268CCAAT/enhancer-binding protein deltaAdd BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ00322
PRIDEiQ00322

PTM databases

iPTMnetiQ00322
PhosphoSitePlusiQ00322

Expressioni

Gene expression databases

CleanExiMM_CEBPD
ExpressionAtlasiQ00322 baseline and differential

Interactioni

Subunit structurei

Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE (PubMed:1884998). Interacts with SPI1/PU.1 (PubMed:7594592). Interacts with PRDM16 (PubMed:19641492).3 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi198670, 6 interactors
DIPiDIP-41645N
IntActiQ00322, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ00322
SMRiQ00322
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 254bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni195 – 222Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni226 – 254Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063192
HOVERGENiHBG050879
InParanoidiQ00322
KOiK10050
OMAiVPNLELC
PhylomeDBiQ00322

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR016468 C/EBP_chordates
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
PIRSFiPIRSF005879 CCAAT/enhancer-binding, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALFSLDS PVRGTPWPTE PAAFYEPGRV DKPGRGPEPG DLGELGSTTP
60 70 80 90 100
AMYDDESAID FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAAGAGGLEL
110 120 130 140 150
LQGGPTRPPG VGSVARGPLK REPDWGDGDA PGSLLPAQVA VCAQTVVSLA
160 170 180 190 200
AAAQPTPPTS PEPPRGSPGP SLAPGTVREK GAGKRGPDRG SPEYRQRRER
210 220 230 240 250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLAGLRQF
260
FKKLPSPPFL PPTGADCR
Length:268
Mass (Da):28,631
Last modified:November 13, 2007 - v2
Checksum:i151F765946CDB275
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41D → E in CAA43905 (PubMed:1840554).Curated1
Sequence conflicti255 – 258PSPP → AQPA in BAC35305 (PubMed:16141072).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61800 mRNA Translation: CAA43905.1
M85144 Genomic DNA No translation available.
AK053190 mRNA Translation: BAC35305.1
AK151958 mRNA Translation: BAE30830.1
CCDSiCCDS84207.1
PIRiB37279
RefSeqiNP_031705.3, NM_007679.4
UniGeneiMm.347407

Genome annotation databases

EnsembliENSMUST00000096232; ENSMUSP00000148145; ENSMUSG00000071637
GeneIDi12609
KEGGimmu:12609
UCSCiuc007yhx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCEBPD_MOUSE
AccessioniPrimary (citable) accession number: Q00322
Secondary accession number(s): Q3U937, Q8BW92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 13, 2007
Last modified: June 20, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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