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UniProtKB - Q00310 (MNT1_CANAL)
Protein
Glycolipid 2-alpha-mannosyltransferase 1
Gene
MNT1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Functioni
Involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Mainly responsible for the addition of the second mannose residue in an O-linked mannose pentamer. Can also substitute for MNT2 by adding the third mannose residue. Important for adherence to host surfaces and for virulence.
1 Publication: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 318 | NucleophileSequence analysis | 1 |
GO - Molecular functioni
- alpha-1,2-mannosyltransferase activity Source: CGD
GO - Biological processi
- cell adhesion involved in multi-species biofilm formation Source: CGD
- cell-cell adhesion Source: CGD
- cell-matrix adhesion Source: CGD
- cell wall mannoprotein biosynthetic process Source: GO_Central
- mannoprotein biosynthetic process Source: CGD
- mannosylation Source: GO_Central
- mitigation of host defenses by symbiont Source: CGD
- protein N-linked glycosylation Source: GO_Central
- protein O-linked glycosylation Source: CGD
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT15, Glycosyltransferase Family 15 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycolipid 2-alpha-mannosyltransferase 1 (EC:2.4.1.-)Alternative name(s): Alpha-1,2-mannosyltransferase 1 |
Gene namesi | Name:MNT1 Synonyms:KRE2, KTR1 Ordered Locus Names:CAALFM_C301810CA ORF Names:CaO19.1665, CaO19.9234 |
Organismi | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Taxonomic identifieri | 237561 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0000188662, MNT1 |
VEuPathDBi | FungiDB:C3_01810C_A |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane Curated; Single-pass type II membrane protein Curated
Extracellular region or secreted
- extracellular region Source: CGD
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: CGD
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: CGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 10 – 28 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 19 | |
Topological domaini | 29 – 431 | LumenalSequence analysisAdd BLAST | 403 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208240 | 1 – 431 | Glycolipid 2-alpha-mannosyltransferase 1Add BLAST | 431 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 73 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 35 – 49 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the glycosyltransferase 15 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4472, Eukaryota |
HOGENOMi | CLU_024327_0_1_1 |
InParanoidi | Q00310 |
OMAi | LTDAPIH |
OrthoDBi | 948664at2759 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR002685, Glyco_trans_15 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR31121, PTHR31121, 1 hit |
Pfami | View protein in Pfam PF01793, Glyco_transf_15, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
Q00310-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASTRSNARL IRFGIFALVL IGCGYILTRG SSFQPPNYQQ TQSPAAHEKQ
60 70 80 90 100
TGNVAAGGGA GSGSAGAQVP LGKNRGPIPK AIMGAGEGGS DAPVPQQDIP
110 120 130 140 150
DSYTLNDKIK ATFVTLARNS DLYSLAESIR HVEDRFNKKF HYDWVFLNDE
160 170 180 190 200
EFNDEFKETV GSLVSGNTKF GLIPKEHWSY PPWIDQEKAA LVREQMREKK
210 220 230 240 250
IIYGHSESYR HMCRFESGFF WRQEILNDYD YYWRVEPDIK LYCDIDYDIF
260 270 280 290 300
KWMKDNNKDY AFTISLPEYK ETIPTLWDTT KEFIEKNPQY LAQNNLMDWV
310 320 330 340 350
SDDKGQTYNG CHFWSNFEIG SLAFWRSEAY RKYFEHLDKA GGFFYERWGD
360 370 380 390 400
APVHSIAAAL FLPREKIHFF EDVGYYHVPF TNCPVDKEVR KARNCNCDPN
410 420 430
KDFTWRGYSC TTKYYTLNNF KRQKGWEKYT A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99619 Genomic DNA Translation: CAA67930.1 CP017625 Genomic DNA Translation: AOW28222.1 |
RefSeqi | XP_721742.1, XM_716649.1 |
Genome annotation databases
GeneIDi | 3636585 |
KEGGi | cal:CAALFM_C301810CA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99619 Genomic DNA Translation: CAA67930.1 CP017625 Genomic DNA Translation: AOW28222.1 |
RefSeqi | XP_721742.1, XM_716649.1 |
3D structure databases
SMRi | Q00310 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 237561.Q00310 |
Protein family/group databases
CAZyi | GT15, Glycosyltransferase Family 15 |
Genome annotation databases
GeneIDi | 3636585 |
KEGGi | cal:CAALFM_C301810CA |
Organism-specific databases
CGDi | CAL0000188662, MNT1 |
VEuPathDBi | FungiDB:C3_01810C_A |
Phylogenomic databases
eggNOGi | KOG4472, Eukaryota |
HOGENOMi | CLU_024327_0_1_1 |
InParanoidi | Q00310 |
OMAi | LTDAPIH |
OrthoDBi | 948664at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Miscellaneous databases
PHI-basei | PHI:104 |
PROi | PR:Q00310 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR002685, Glyco_trans_15 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR31121, PTHR31121, 1 hit |
Pfami | View protein in Pfam PF01793, Glyco_transf_15, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MNT1_CANAL | |
Accessioni | Q00310Primary (citable) accession number: Q00310 Secondary accession number(s): A0A1D8PJA3, Q5AJC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Candida albicans
Candida albicans: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families