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Protein

Paired box protein Pax-8

Gene

Pax8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-8
Gene namesi
Name:Pax8
Synonyms:Pax-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97492 Pax8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501981 – 457Paired box protein Pax-8Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei304PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ00288
PaxDbiQ00288
PRIDEiQ00288

PTM databases

iPTMnetiQ00288
PhosphoSitePlusiQ00288

Expressioni

Tissue specificityi

Expressed in the developing excretory system and the thyroid gland.

Gene expression databases

BgeeiENSMUSG00000026976 Expressed in 125 organ(s), highest expression level in early tubule (mouse)
CleanExiMM_PAX8
ExpressionAtlasiQ00288 baseline and differential
GenevisibleiQ00288 MM

Interactioni

Subunit structurei

Interacts with WWTR1.By similarity

Protein-protein interaction databases

BioGridi202035, 2 interactors
IntActiQ00288, 1 interactor
STRINGi10090.ENSMUSP00000028355

Structurei

3D structure databases

ProteinModelPortaliQ00288
SMRiQ00288
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 135PairedPROSITE-ProRule annotationAdd BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi316 – 328Ser-richAdd BLAST13

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3862 Eukaryota
ENOG410ZT0S LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230938
HOVERGENiHBG009115
InParanoidiQ00288
KOiK09293
OMAiDTFSQHH
OrthoDBiEOG091G0S4E
TreeFamiTF315397

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q00288-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ
60 70 80 90 100
LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP
110 120 130 140 150
TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT
160 170 180 190 200
KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGNDNKRKMD
210 220 230 240 250
DSDQDSCRLS IDSQSSSSGP RKHLRTDTFS QHHLEALECP FERQHYPEAY
260 270 280 290 300
ASPSHTKGEQ GLYPLPLLNS ALDDGKATLT SSNTPLGRNL STHQTYPVVA
310 320 330 340 350
DPHSPFAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN
360 370 380 390 400
AFPHAASVYG QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG
410 420 430 440 450
MVAGSEYSGN AYSHTPYSSY SEAWRFPNSS LLSSPYYYSS TSRPSAPPTS

ATAFDHL
Length:457
Mass (Da):48,793
Last modified:July 27, 2011 - v3
Checksum:iAAACD3EE54AA4488
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AIU8A2AIU8_MOUSE
Paired box protein Pax-8
Pax8
169Annotation score:
A2AIU7A2AIU7_MOUSE
Paired box protein Pax-8
Pax8
404Annotation score:
A2AIU6A2AIU6_MOUSE
Paired box protein Pax-8
Pax8
412Annotation score:
G3UZ49G3UZ49_MOUSE
Paired box protein Pax-8
Pax8
322Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340G → D no nucleotide entry (PubMed:1516825).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57487 mRNA Translation: CAA40725.1
X99592
, X99593, X99594, X99595, X99596, X99597, X99598 Genomic DNA Translation: CAA67904.1
AL732528 Genomic DNA Translation: CAM17808.1
CH466542 Genomic DNA Translation: EDL08172.1
BC020526 mRNA Translation: AAH20526.1
CCDSiCCDS15738.1
PIRiA56925
RefSeqiNP_035170.1, NM_011040.4
UniGeneiMm.2533

Genome annotation databases

EnsembliENSMUST00000028355; ENSMUSP00000028355; ENSMUSG00000026976
GeneIDi18510
KEGGimmu:18510
UCSCiuc008ipb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57487 mRNA Translation: CAA40725.1
X99592
, X99593, X99594, X99595, X99596, X99597, X99598 Genomic DNA Translation: CAA67904.1
AL732528 Genomic DNA Translation: CAM17808.1
CH466542 Genomic DNA Translation: EDL08172.1
BC020526 mRNA Translation: AAH20526.1
CCDSiCCDS15738.1
PIRiA56925
RefSeqiNP_035170.1, NM_011040.4
UniGeneiMm.2533

3D structure databases

ProteinModelPortaliQ00288
SMRiQ00288
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202035, 2 interactors
IntActiQ00288, 1 interactor
STRINGi10090.ENSMUSP00000028355

PTM databases

iPTMnetiQ00288
PhosphoSitePlusiQ00288

Proteomic databases

MaxQBiQ00288
PaxDbiQ00288
PRIDEiQ00288

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028355; ENSMUSP00000028355; ENSMUSG00000026976
GeneIDi18510
KEGGimmu:18510
UCSCiuc008ipb.2 mouse

Organism-specific databases

CTDi7849
MGIiMGI:97492 Pax8

Phylogenomic databases

eggNOGiKOG3862 Eukaryota
ENOG410ZT0S LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230938
HOVERGENiHBG009115
InParanoidiQ00288
KOiK09293
OMAiDTFSQHH
OrthoDBiEOG091G0S4E
TreeFamiTF315397

Miscellaneous databases

PROiPR:Q00288
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026976 Expressed in 125 organ(s), highest expression level in early tubule (mouse)
CleanExiMM_PAX8
ExpressionAtlasiQ00288 baseline and differential
GenevisibleiQ00288 MM

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAX8_MOUSE
AccessioniPrimary (citable) accession number: Q00288
Secondary accession number(s): P97342, Q6GU20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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