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Protein

Syntaxin-2

Gene

Stx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.2 Publications

GO - Molecular functioni

  • calcium-dependent protein binding Source: HGNC
  • protein dimerization activity Source: MGI
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-2
Alternative name(s):
Epimorphin
Gene namesi
Name:Stx2
Synonyms:Epim
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108059 Stx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 265CytoplasmicSequence analysisAdd BLAST265
Transmembranei266 – 289Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101971 – 289Syntaxin-2Add BLAST289

Proteomic databases

EPDiQ00262
MaxQBiQ00262
PaxDbiQ00262
PeptideAtlasiQ00262
PRIDEiQ00262

PTM databases

iPTMnetiQ00262
PhosphoSitePlusiQ00262

Expressioni

Gene expression databases

CleanExiMM_STX2

Interactioni

Subunit structurei

Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031378

Structurei

3D structure databases

ProteinModelPortaliQ00262
SMRiQ00262
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 254t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili68 – 101Sequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiQ00262
PhylomeDBiQ00262

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR028671 STX2
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF36 PTHR19957:SF36, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q00262-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDRLPDLTA CRTNDDGDTA VVIVEKDHFM DGFFHQVEEI RSSIARIAQH
60 70 80 90 100
VEDVKKNHSI ILSAPNPEGK IKEELEDLDK EIKKTANRIR GKLKSIEQSC
110 120 130 140 150
DQDENGNRTS VDLRIRRTQH SVLSRKFVDV MTEYNEAQIL FRERSKGRIQ
160 170 180 190 200
RQLEITGRTT TDDELEEMLE SGKPSIFISD IISDSQITRQ ALNEIESRHK
210 220 230 240 250
DIMKLETSIR ELHEMFMDMA MFVETQGEMV NNIERNVVNS VDYVEHAKEE
260 270 280
TKKAIKYQSK ARRKKWIIAA VAVAVIAVLA LIIGLSVGK
Length:289
Mass (Da):33,178
Last modified:December 1, 1992 - v1
Checksum:i9D82330D0F5CA2F4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80W45Q80W45_MOUSE
Syntaxin-2
Stx2 Epim
289Annotation score:
Q3TJ55Q3TJ55_MOUSE
Syntaxin-2
Stx2 Epim
288Annotation score:
D3YY94D3YY94_MOUSE
Syntaxin-2
Stx2
85Annotation score:
A0A0G2JE94A0A0G2JE94_MOUSE
Syntaxin-2
Stx2
42Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10475 mRNA Translation: BAA01278.1
CCDSiCCDS19692.1
PIRiA38216 S51193
UniGeneiMm.260716

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10475 mRNA Translation: BAA01278.1
CCDSiCCDS19692.1
PIRiA38216 S51193
UniGeneiMm.260716

3D structure databases

ProteinModelPortaliQ00262
SMRiQ00262
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031378

PTM databases

iPTMnetiQ00262
PhosphoSitePlusiQ00262

Proteomic databases

EPDiQ00262
MaxQBiQ00262
PaxDbiQ00262
PeptideAtlasiQ00262
PRIDEiQ00262

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108059 Stx2

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiQ00262
PhylomeDBiQ00262

Miscellaneous databases

ChiTaRSiStx2 mouse
PROiPR:Q00262
SOURCEiSearch...

Gene expression databases

CleanExiMM_STX2

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR028671 STX2
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF36 PTHR19957:SF36, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX2_MOUSE
AccessioniPrimary (citable) accession number: Q00262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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