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Entry version 180 (12 Aug 2020)
Sequence version 4 (18 Mar 2008)
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Protein

POU domain, class 2, transcription factor 2

Gene

Pou2f2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2011512, PubMed:1281152). Regulates IL6 expression in B cells with POU2AF1 (PubMed:23045607). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.By similarity5 Publications
Activates octamer-containing promoters.2 Publications
Activates octamer-containing promoters.2 Publications
Activates octamer-containing promoters.2 Publications
Represses some promoters and activate others.2 Publications
Represses some promoters and activate others (PubMed:1281152, PubMed:2011512). Activates the U2 small nuclear RNA (snRNA) promoter (By similarity).By similarity2 Publications
Unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Transactivation activity is enhanced by transcriptional coactivator POU2AF1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi281 – 340HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6807505, RNA polymerase II transcribes snRNA genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POU domain, class 2, transcription factor 2Curated
Alternative name(s):
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
Octamer-binding protein 2
Short name:
Oct-2
Octamer-binding transcription factor 2
Short name:
OTF-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pou2f2Imported
Synonyms:Oct2, Otf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:101897, Pou2f2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants show normal development of germinal center B cells when infected by influenza virus.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007151 – 463POU domain, class 2, transcription factor 2Add BLAST463

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q00196

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q00196

PRoteomics IDEntifications database

More...
PRIDEi
Q00196

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q00196

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q00196

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest in B cells, but also present in brain (neuronal and glial cells), intestine, kidney, and testes.3 Publications
Expressed at higher levels in B-cells than in neuronal cells.1 Publication
Expressed in neuronal cell lines and brain, but not dorsal root ganglia.1 Publication
Expressed at lower levels in neuronal cells than in B cells.1 Publication
Expressed in neuronal cell lines, and at lower levels in neuroblastoma and dorsal root ganglia.1 Publication
Widely expressed in the developing nervous system but expression is confined to very specific regions in the adult brain, it is expressed at a lower level in B cells.1 Publication
Either absent in, or expressed at very low levels in neuronal cells and brain.1 Publication
Expressed in all tissues tested: mammary gland, liver, spleen, lung, kidney intestine, uterus and ovary of a virgin mouse. Levels of isoform OCT2.7 are highest in spleen and lung. In mammary gland, expression is localized to the alveolus epithelial cells.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely but not homogeneously expressed in developing nervous system. Expression levels in mammary glands are barely detectable in virgin mice, levels increase during pregnancy, reaching a maximum during late pregnancy, then decrease during lactation becoming very low post-lactation.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In B cells, expression is highly increased upon activation by LPS or CpG.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000008496, Expressed in brain and 135 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q00196, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NR3C1, AR and PGR.

Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104056

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q00196, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q00196

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini179 – 253POU-specificPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni373 – 394Leucine-zipperSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi77 – 82Poly-Pro6
Compositional biasi401 – 408Poly-Gly8
Compositional biasi421 – 424Poly-Pro4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3802, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160115

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013065_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00196

KEGG Orthology (KO)

More...
KOi
K09364

Identification of Orthologs from Complete Genome Data

More...
OMAi
DAGTETM

Database of Orthologous Groups

More...
OrthoDBi
873012at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q00196

TreeFam database of animal gene trees

More...
TreeFami
TF316413

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom
IPR000972, TF_octamer

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00029, OCTAMER
PR00028, POUDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform OCT2.1 (identifier: Q00196-1) [UniParc]FASTAAdd to basket
Also known as: Major form

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHSSMGAPE IRMSKPLEAE KQSLDSPSEH TDTERNGPDI NHQNPQNKAS
60 70 80 90 100
PFSVSPTGPS TKIKAEDPSG DSAPAAPPPP QPAQPHLPQA QLMLTGSQLA
110 120 130 140 150
GDIQQLLQLQ QLVLVPGHHL QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ
160 170 180 190 200
TQGALLTSQP RAGLPTQPPK CLEPPSHPEE PSDLEELEQF ARTFKQRRIK
210 220 230 240 250
LGFTQGDVGL AMGKLYGNDF SQTTISRFEA LNLSFKNMCK LKPLLEKWLN
260 270 280 290 300
DAETMSVDSS LPSPNQLSSP SLGFDGLPGR RRKKRTSIET NVRFALEKSF
310 320 330 340 350
LANQKPTSEE ILLIAEQLHM EKEVIRVWFC NRRQKEKRIN PCSAAPMLPS
360 370 380 390 400
PGKPTSYSPH LVTPQGGAGT LPLSQASSSL STTVTTLSSA VGTLHPSRTA
410 420 430 440 450
GGGGGGGGAA PPLNSIPSVT PPPPATTNST NPSPQGSHSA IGLSGLNPSA
460
GPGLWWNPAP YQP
Length:463
Mass (Da):49,439
Last modified:March 18, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6669B5885ABD789
GO
Isoform OCT2.2 (identifier: Q00196-2) [UniParc]FASTAAdd to basket
Also known as: OCT2a

The sequence of this isoform differs from the canonical sequence as follows:
     167-167: Q → QAMTRPTLPDPHLSHPQ

Note: The isoform OCT2b described in PubMed:7888080 corresponds to the isoform OCT2a of PubMed:1976089. To avoid any confusion, we use the nomenclature from PubMed:2011512 to describe the different isoforms.
Show »
Length:479
Mass (Da):51,219
Checksum:i54F4280848EA87AA
GO
Isoform OCT2.3 (identifier: Q00196-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: K → KVGILSGLHLTFWGPGPCLSPPQ

Show »
Length:485
Mass (Da):51,698
Checksum:i737D181B5B999C4E
GO
Isoform OCT2.4 (identifier: Q00196-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     384-400: VTTLSSAVGTLHPSRTA → AQTRALKAATRLLACRA
     401-463: Missing.

Show »
Length:400
Mass (Da):43,649
Checksum:iDEEBC8432E8A900E
GO
Isoform OCT2.5 (identifier: Q00196-5) [UniParc]FASTAAdd to basket
Also known as: OCT2b

The sequence of this isoform differs from the canonical sequence as follows:
     452-463: PGLWWNPAPYQP → STMVGLSSGL...GGPEAGSKAE

Note: The isoform OCT2b described in PubMed:7888080 corresponds to the isoform OCT2a of PubMed:1976089. To avoid any confusion, we use the nomenclature from PubMed:2011512 to describe the different isoforms.
Show »
Length:583
Mass (Da):60,141
Checksum:iDC702E46F07A7C55
GO
Isoform OCT2.6 (identifier: Q00196-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-101: Missing.

Show »
Length:424
Mass (Da):45,572
Checksum:i53F6B1E7C65A2BBA
GO
Isoform OCT2.7 (identifier: Q00196-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: K → KVGILSGLHLTFWGPGPCLSPPQ
     452-463: PGLWWNPAPYQP → STMVGLSSGL...LHPHLSSGKV

Show »
Length:549
Mass (Da):58,076
Checksum:iC48D3795D52A998C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BKB7H3BKB7_MOUSE
POU domain protein
Pou2f2
467Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6X6U7F6X6U7_MOUSE
POU domain, class 2, transcription ...
Pou2f2
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAU95617 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAE33673 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti409A → R in CAA41004 (PubMed:2011512).Curated1
Sequence conflicti409A → R in CAA41005 (PubMed:2011512).Curated1
Sequence conflicti409A → R in CAA41006 (PubMed:2011512).Curated1
Sequence conflicti409A → R in CAA41008 (PubMed:2011512).Curated1
Sequence conflicti409A → R in CAA41009 (PubMed:2011512).Curated1
Sequence conflicti411P → L in CAA41004 (PubMed:2011512).Curated1
Sequence conflicti411P → L in CAA41005 (PubMed:2011512).Curated1
Sequence conflicti411P → L in CAA41006 (PubMed:2011512).Curated1
Sequence conflicti411P → L in CAA41008 (PubMed:2011512).Curated1
Sequence conflicti411P → L in CAA41009 (PubMed:2011512).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00232662K → KVGILSGLHLTFWGPGPCLS PPQ in isoform OCT2.3 and isoform OCT2.7. 3 Publications1
Alternative sequenceiVSP_00232763 – 101Missing in isoform OCT2.6. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_002328167Q → QAMTRPTLPDPHLSHPQ in isoform OCT2.2. 2 Publications1
Alternative sequenceiVSP_002329384 – 400VTTLS…PSRTA → AQTRALKAATRLLACRA in isoform OCT2.4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_002330401 – 463Missing in isoform OCT2.4. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_002331452 – 463PGLWW…APYQP → STMVGLSSGLSPALMSNNPL ATIQALASGGTLPLTSLDGS GNLVLGAAGAAPGSPSLVTS PLFLNHTGLPLLSAPPGVGL VSAAAAAVAASISSKSPGLS SSSSSSSSSTCSDVAAQTPG GPGGPEAGSKAE in isoform OCT2.5. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_032188452 – 463PGLWW…APYQP → STMVGLSSGLSPALMSNNPL ATIQGACCLMSPHCHQSCPL LGLEPTLPHCCPSHAIPPPC SLHCSPLHPHLSSGKV in isoform OCT2.7. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X53654 mRNA Translation: CAA37702.1
X57936 mRNA Translation: CAA41004.1
X57937 mRNA Translation: CAA41005.1
X57938 mRNA Translation: CAA41006.1
X57939 mRNA Translation: CAA41007.1
X57940 mRNA Translation: CAA41008.1
X57941 mRNA Translation: CAA41009.1
AY746973 mRNA Translation: AAU95616.1
AY746974 mRNA Translation: AAU95617.1 Different initiation.
AK156322 mRNA Translation: BAE33673.1 Frameshift.
BC104488 mRNA Translation: AAI04489.1
BC105647 mRNA Translation: AAI05648.1
BC105920 mRNA Translation: AAI05921.1
BC105921 mRNA Translation: AAI05922.1
X81031 Genomic DNA Translation: CAA56934.1
X51961 mRNA Translation: CAA36220.1
X57089 mRNA Translation: CAA40369.1
S55236 mRNA Translation: AAA11815.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39834.1 [Q00196-2]
CCDS52143.1 [Q00196-1]
CCDS52144.1 [Q00196-5]
CCDS52145.1 [Q00196-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
S22539
S22542
S22543
S22544

NCBI Reference Sequences

More...
RefSeqi
NP_001157026.1, NM_001163554.1 [Q00196-5]
NP_001157027.1, NM_001163555.1 [Q00196-3]
NP_001157028.1, NM_001163556.1 [Q00196-1]
NP_035268.2, NM_011138.2 [Q00196-2]
XP_006539722.1, XM_006539659.2 [Q00196-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000098679; ENSMUSP00000096276; ENSMUSG00000008496 [Q00196-7]
ENSMUST00000108413; ENSMUSP00000104051; ENSMUSG00000008496 [Q00196-4]
ENSMUST00000108415; ENSMUSP00000104053; ENSMUSG00000008496 [Q00196-2]
ENSMUST00000108416; ENSMUSP00000104054; ENSMUSG00000008496 [Q00196-6]
ENSMUST00000108417; ENSMUSP00000104055; ENSMUSG00000008496 [Q00196-3]
ENSMUST00000108418; ENSMUSP00000104056; ENSMUSG00000008496 [Q00196-5]
ENSMUST00000175774; ENSMUSP00000135075; ENSMUSG00000008496 [Q00196-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18987

UCSC genome browser

More...
UCSCi
uc009frm.1, mouse [Q00196-7]
uc009frn.2, mouse [Q00196-2]
uc009fro.2, mouse [Q00196-5]
uc009frp.2, mouse [Q00196-1]
uc009frq.2, mouse [Q00196-3]
uc009frr.2, mouse [Q00196-4]
uc012ffp.1, mouse [Q00196-6]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53654 mRNA Translation: CAA37702.1
X57936 mRNA Translation: CAA41004.1
X57937 mRNA Translation: CAA41005.1
X57938 mRNA Translation: CAA41006.1
X57939 mRNA Translation: CAA41007.1
X57940 mRNA Translation: CAA41008.1
X57941 mRNA Translation: CAA41009.1
AY746973 mRNA Translation: AAU95616.1
AY746974 mRNA Translation: AAU95617.1 Different initiation.
AK156322 mRNA Translation: BAE33673.1 Frameshift.
BC104488 mRNA Translation: AAI04489.1
BC105647 mRNA Translation: AAI05648.1
BC105920 mRNA Translation: AAI05921.1
BC105921 mRNA Translation: AAI05922.1
X81031 Genomic DNA Translation: CAA56934.1
X51961 mRNA Translation: CAA36220.1
X57089 mRNA Translation: CAA40369.1
S55236 mRNA Translation: AAA11815.1
CCDSiCCDS39834.1 [Q00196-2]
CCDS52143.1 [Q00196-1]
CCDS52144.1 [Q00196-5]
CCDS52145.1 [Q00196-3]
PIRiS22539
S22542
S22543
S22544
RefSeqiNP_001157026.1, NM_001163554.1 [Q00196-5]
NP_001157027.1, NM_001163555.1 [Q00196-3]
NP_001157028.1, NM_001163556.1 [Q00196-1]
NP_035268.2, NM_011138.2 [Q00196-2]
XP_006539722.1, XM_006539659.2 [Q00196-7]

3D structure databases

SMRiQ00196
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104056

PTM databases

iPTMnetiQ00196
PhosphoSitePlusiQ00196

Proteomic databases

MaxQBiQ00196
PaxDbiQ00196
PRIDEiQ00196

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3745, 551 antibodies

Genome annotation databases

EnsembliENSMUST00000098679; ENSMUSP00000096276; ENSMUSG00000008496 [Q00196-7]
ENSMUST00000108413; ENSMUSP00000104051; ENSMUSG00000008496 [Q00196-4]
ENSMUST00000108415; ENSMUSP00000104053; ENSMUSG00000008496 [Q00196-2]
ENSMUST00000108416; ENSMUSP00000104054; ENSMUSG00000008496 [Q00196-6]
ENSMUST00000108417; ENSMUSP00000104055; ENSMUSG00000008496 [Q00196-3]
ENSMUST00000108418; ENSMUSP00000104056; ENSMUSG00000008496 [Q00196-5]
ENSMUST00000175774; ENSMUSP00000135075; ENSMUSG00000008496 [Q00196-1]
GeneIDi18987
KEGGimmu:18987
UCSCiuc009frm.1, mouse [Q00196-7]
uc009frn.2, mouse [Q00196-2]
uc009fro.2, mouse [Q00196-5]
uc009frp.2, mouse [Q00196-1]
uc009frq.2, mouse [Q00196-3]
uc009frr.2, mouse [Q00196-4]
uc012ffp.1, mouse [Q00196-6]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5452
MGIiMGI:101897, Pou2f2

Phylogenomic databases

eggNOGiKOG3802, Eukaryota
GeneTreeiENSGT00940000160115
HOGENOMiCLU_013065_4_1_1
InParanoidiQ00196
KOiK09364
OMAiDAGTETM
OrthoDBi873012at2759
PhylomeDBiQ00196
TreeFamiTF316413

Enzyme and pathway databases

ReactomeiR-MMU-6807505, RNA polymerase II transcribes snRNA genes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18987, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pou2f2, mouse

Protein Ontology

More...
PROi
PR:Q00196
RNActiQ00196, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000008496, Expressed in brain and 135 other tissues
GenevisibleiQ00196, MM

Family and domain databases

CDDicd00086, homeodomain, 1 hit
Gene3Di1.10.260.40, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom
IPR000972, TF_octamer
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit
PRINTSiPR00029, OCTAMER
PR00028, POUDOMAIN
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPO2F2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00196
Secondary accession number(s): Q00197
, Q00198, Q00199, Q00200, Q00201, Q05882, Q3KR47, Q3U127, Q5XML1, Q5XML2, Q61995, Q61996, Q64245
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 18, 2008
Last modified: August 12, 2020
This is version 180 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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