UniProtKB - Q00177 (XYNC_EMENI)

BLAST

>sp|Q00177|XYNC_EMENI Endo-1,4-beta-xylanase C OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=xlnC PE=1 SV=1
MVHLKTLAGSAVFASLATAAVLPRQSASLNDLFVAAGKSYFGTCSDQALLQNSQNEAIVA
SQFGVITPENSMKWDALEPSQGNFGWSGADYLVDYATQHNKKVRGHTLVWHSQLPSWVSS
IGDANTLRSVMTNHINEVVGRYKGKIMHWDVVNEIFNEDGTFRNSVFYNLLGEDFVRIAF
ETARAADPDAKLYINDYNLDSASYAKTQAMASYVKKWLAEGVPIDGIGSQAHYSSSHWSS
TEAAGALSSLANTGVSEVAITELDIAGAASSDYLNLLNACLNEQKCVGITVWGVSDKDSW
RASDSPLLFDGNYQPKDAYNAIVNALS

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History
Entry version 119 (20 Jun 2018)
Sequence version 1 (01 Nov 1996)
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Protein

Endo-1,4-beta-xylanase C

Gene

xlnC

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.2 Publications

Catalytic activityⁱ

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

pH dependenceⁱ

Optimum pH is 4.9.1 Publication

Temperature dependenceⁱ

Optimum temperature is 52 degrees Celsius.1 Publication

Pathwayⁱ: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	154	Proton donorBy similarity		1
Active siteⁱ	262	NucleophileBy similarity		1

GO - Molecular functionⁱ

endo-1,4-beta-xylanase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16844780

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

xylan catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16844780

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Biological process	Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

BRENDAⁱ	3.2.1.8 517
UniPathwayⁱ	UPA00114

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH10 Glycoside Hydrolase Family 10

CAZyⁱ

GH10 Glycoside Hydrolase Family 10

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endo-1,4-beta-xylanase C (EC:3.2.1.8) Short name: Xylanase C Alternative name(s): 1,4-beta-D-xylan xylanohydrolase C 34 kDa xylanase Xylanase X34
Gene namesⁱ	Name:xlnC ORF Names:AN1818
Organismⁱ	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifierⁱ	227321 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Emericella nidulans
Proteomesⁱ	UP000000560 Componentⁱ: Chromosome VII UP000005890 Componentⁱ: Unassembled WGS sequence

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	By similarityAdd BLAST		24
ChainⁱPRO_0000007974	25 – 327	Endo-1,4-beta-xylanase CAdd BLAST		303

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	25	Pyrrolidone carboxylic acidBy similarity		1
Disulfide bondⁱ	280 ↔ 286	1 Publication

Keywords - PTMⁱ

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEⁱ	Q00177

PRIDEⁱ

Q00177

Expressionⁱ

Inductionⁱ

Expressed in presence of xylan and repressed by glucose.1 Publication

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	29 – 35	Combined sources	7
Beta strandⁱ	39 – 45	Combined sources	7
Helixⁱ	47 – 51	Combined sources	5
Helixⁱ	53 – 62	Combined sources	10
Beta strandⁱ	64 – 70	Combined sources	7
Helixⁱ	74 – 77	Combined sources	4
Helixⁱ	87 – 98	Combined sources	12
Beta strandⁱ	102 – 109	Combined sources	8
Beta strandⁱ	111 – 113	Combined sources	3
Helixⁱ	116 – 119	Combined sources	4
Helixⁱ	124 – 141	Combined sources	18
Turnⁱ	142 – 144	Combined sources	3
Beta strandⁱ	147 – 154	Combined sources	8
Beta strandⁱ	160 – 162	Combined sources	3
Helixⁱ	166 – 171	Combined sources	6
Helixⁱ	174 – 186	Combined sources	13
Beta strandⁱ	190 – 197	Combined sources	8
Helixⁱ	205 – 219	Combined sources	15
Beta strandⁱ	226 – 229	Combined sources	4
Helixⁱ	240 – 242	Combined sources	3
Helixⁱ	243 – 251	Combined sources	9
Beta strandⁱ	256 – 265	Combined sources	10
Helixⁱ	270 – 281	Combined sources	12
Beta strandⁱ	286 – 292	Combined sources	7
Helixⁱ	296 – 298	Combined sources	3
Helixⁱ	302 – 304	Combined sources	3
Beta strandⁱ	307 – 309	Combined sources	3
Helixⁱ	317 – 326	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	Q00177
SMRⁱ	Q00177
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q00177

EvolutionaryTraceⁱ

Q00177

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 325	GH10PROSITE-ProRule annotationAdd BLAST		282

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 10 (cellulase F) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

HOGENOMⁱ	HOG000019847
InParanoidⁱ	Q00177
KEGG Orthology (KO) More...KOⁱ	K01181
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C45ID

Family and domain databases

InterProⁱ	View protein in InterPro IPR001000 GH10 IPR017853 Glycoside_hydrolase_SF
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00331 Glyco_hydro_10, 1 hit
PRINTSⁱ	PR00134 GLHYDRLASE10
SMARTⁱ	View protein in SMART SM00633 Glyco_10, 1 hit
SUPFAMⁱ	SSF51445 SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS51760 GH10_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q00177-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVHLKTLAGS AVFASLATAA VLPRQSASLN DLFVAAGKSY FGTCSDQALL 
        60         70         80         90        100
QNSQNEAIVA SQFGVITPEN SMKWDALEPS QGNFGWSGAD YLVDYATQHN 
       110        120        130        140        150
KKVRGHTLVW HSQLPSWVSS IGDANTLRSV MTNHINEVVG RYKGKIMHWD 
       160        170        180        190        200
VVNEIFNEDG TFRNSVFYNL LGEDFVRIAF ETARAADPDA KLYINDYNLD 
       210        220        230        240        250
SASYAKTQAM ASYVKKWLAE GVPIDGIGSQ AHYSSSHWSS TEAAGALSSL 
       260        270        280        290        300
ANTGVSEVAI TELDIAGAAS SDYLNLLNAC LNEQKCVGIT VWGVSDKDSW 
       310        320 
RASDSPLLFD GNYQPKDAYN AIVNALS

Length:327

Mass (Da):35,441

Last modified:November 1, 1996 - v1

Checksum:ⁱB59CF4DE435F6F20

Sequence cautionⁱ

The sequence CBF85620 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence EAA64983 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z49894 Genomic DNA Translation: CAA90075.1 DQ490475 mRNA Translation: ABF50851.1 AACD01000029 Genomic DNA Translation: EAA64983.1 Sequence problems. BN001307 Genomic DNA Translation: CBF85620.1 Sequence problems.
PIRⁱ	JC5034
NCBI Reference Sequences More...RefSeqⁱ	XP_659422.1, XM_654330.1

Genome annotation databases

EnsemblFungiⁱ	EAA64983; EAA64983; AN1818.2
GeneIDⁱ	2874673
KEGGⁱ	ani:AN1818.2

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q00177	Endo-1,4-beta-xylanase F1		ASPOR		327	UniRef50_Q00177
Probable endo-1,4-beta-xylanase F3		ASPFN		324
Endo-1,4-beta-xylanase A		ASPKW		327
Probable endo-1,4-beta-xylanase C	)	ASPNC		327
Probable endo-1,4-beta-xylanase C		ASPNG		327
+136

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z49894 Genomic DNA Translation: CAA90075.1 DQ490475 mRNA Translation: ABF50851.1 AACD01000029 Genomic DNA Translation: EAA64983.1 Sequence problems. BN001307 Genomic DNA Translation: CBF85620.1 Sequence problems.
PIRⁱ	JC5034
RefSeqⁱ	XP_659422.1, XM_654330.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1TA3	X-ray	1.70	B	25-327	[»]
ProteinModelPortalⁱ	Q00177
SMRⁱ	Q00177
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

CAZyⁱ	GH10 Glycoside Hydrolase Family 10

CAZyⁱ

GH10 Glycoside Hydrolase Family 10

Proteomic databases

PRIDEⁱ	Q00177

PRIDEⁱ

Q00177

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	EAA64983; EAA64983; AN1818.2
GeneIDⁱ	2874673
KEGGⁱ	ani:AN1818.2

Phylogenomic databases

HOGENOMⁱ	HOG000019847
InParanoidⁱ	Q00177
KOⁱ	K01181
OrthoDBⁱ	EOG092C45ID

Enzyme and pathway databases

UniPathwayⁱ	UPA00114
BRENDAⁱ	3.2.1.8 517

Miscellaneous databases

EvolutionaryTraceⁱ	Q00177

EvolutionaryTraceⁱ

Q00177

Family and domain databases

InterProⁱ	View protein in InterPro IPR001000 GH10 IPR017853 Glycoside_hydrolase_SF
Pfamⁱ	View protein in Pfam PF00331 Glyco_hydro_10, 1 hit
PRINTSⁱ	PR00134 GLHYDRLASE10
SMARTⁱ	View protein in SMART SM00633 Glyco_10, 1 hit
SUPFAMⁱ	SSF51445 SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS51760 GH10_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	XYNC_EMENI
Accessionⁱ	Q00177Primary (citable) accession number: Q00177 Secondary accession number(s): C8VPM8, Q1HFU9, Q5BCB2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	June 20, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q00177 (XYNC_EMENI)

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Endo-1,4-beta-xylanase C

xlnC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Temperature dependencei

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: xylan degradation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

pH dependenceⁱ

Temperature dependenceⁱ

Pathwayⁱ: xylan degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ