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Protein

Phosphatidylinositol transfer protein alpha isoform

Gene

PITPNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei60Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei85Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei89Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei96Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei194Phosphatidylinositol lipid headgroup1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Chemistry databases

SwissLipidsiSLP:000000415

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein alpha isoform
Short name:
PI-TP-alpha
Short name:
PtdIns transfer protein alpha
Short name:
PtdInsTP alpha
Gene namesi
Name:PITPNA
Synonyms:PITPN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000174238.14
HGNCiHGNC:9001 PITPNA
MIMi600174 gene
neXtProtiNX_Q00169

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5306
OpenTargetsiENSG00000174238
PharmGKBiPA33335

Polymorphism and mutation databases

BioMutaiPITPNA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916391 – 270Phosphatidylinositol transfer protein alpha isoformAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ00169
PaxDbiQ00169
PeptideAtlasiQ00169
PRIDEiQ00169
ProteomicsDBi57841

PTM databases

iPTMnetiQ00169
PhosphoSitePlusiQ00169

Expressioni

Tissue specificityi

Expressed in a wide range of tissues.

Gene expression databases

BgeeiENSG00000174238 Expressed in 231 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_PITPNA
ExpressionAtlasiQ00169 baseline and differential
GenevisibleiQ00169 HS

Organism-specific databases

HPAiHPA000528

Interactioni

Protein-protein interaction databases

BioGridi111323, 25 interactors
IntActiQ00169, 7 interactors
MINTiQ00169
STRINGi9606.ENSP00000316809

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ00169
SMRiQ00169
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00169

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3668 Eukaryota
COG5083 LUCA
GeneTreeiENSGT00760000119216
HOVERGENiHBG058915
InParanoidiQ00169
OMAiETWHKSD
PhylomeDBiQ00169
TreeFamiTF313279

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR001666 PI_transfer
IPR023393 START-like_dom_sf
PANTHERiPTHR10658 PTHR10658, 1 hit
PfamiView protein in Pfam
PF02121 IP_trans, 1 hit
PRINTSiPR00391 PITRANSFER

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q00169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK
60 70 80 90 100
DGEKGQYTHK IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN
110 120 130 140 150
EYMKEDFLIK IETWHKPDLG TQENVHKLEP EAWKHVEAVY IDIADRSQVL
160 170 180 190 200
SKDYKAEEDP AKFKSIKTGR GPLGPNWKQE LVNQKDCPYM CAYKLVTVKF
210 220 230 240 250
KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM DDIRRMEEET
260 270
KRQLDEMRQK DPVKGMTADD
Length:270
Mass (Da):31,806
Last modified:January 23, 2007 - v2
Checksum:i4531E6E38697C93B
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GWE5F5GWE5_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
270Annotation score:
I3L459I3L459_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
142Annotation score:
I3L4U7I3L4U7_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
121Annotation score:
I3NI10I3NI10_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
66Annotation score:
I3L3W1I3L3W1_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
44Annotation score:
I3L4C0I3L4C0_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
115Annotation score:
I3L2X8I3L2X8_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
83Annotation score:
I3L471I3L471_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
98Annotation score:
I3L4H1I3L4H1_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
209Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45N → P in BAA06276 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73704 mRNA Translation: AAA36441.1
D30036 mRNA Translation: BAA06276.1
BC082976 mRNA Translation: AAH82976.1
BC045108 mRNA Translation: AAH45108.1
CCDSiCCDS45563.1
PIRiI53775
RefSeqiNP_006215.1, NM_006224.3
UniGeneiHs.429819

Genome annotation databases

EnsembliENST00000313486; ENSP00000316809; ENSG00000174238
GeneIDi5306
KEGGihsa:5306

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73704 mRNA Translation: AAA36441.1
D30036 mRNA Translation: BAA06276.1
BC082976 mRNA Translation: AAH82976.1
BC045108 mRNA Translation: AAH45108.1
CCDSiCCDS45563.1
PIRiI53775
RefSeqiNP_006215.1, NM_006224.3
UniGeneiHs.429819

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UW5X-ray2.90A/B/C/D1-270[»]
ProteinModelPortaliQ00169
SMRiQ00169
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111323, 25 interactors
IntActiQ00169, 7 interactors
MINTiQ00169
STRINGi9606.ENSP00000316809

Chemistry databases

SwissLipidsiSLP:000000415

PTM databases

iPTMnetiQ00169
PhosphoSitePlusiQ00169

Polymorphism and mutation databases

BioMutaiPITPNA

Proteomic databases

EPDiQ00169
PaxDbiQ00169
PeptideAtlasiQ00169
PRIDEiQ00169
ProteomicsDBi57841

Protocols and materials databases

DNASUi5306
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313486; ENSP00000316809; ENSG00000174238
GeneIDi5306
KEGGihsa:5306

Organism-specific databases

CTDi5306
DisGeNETi5306
EuPathDBiHostDB:ENSG00000174238.14
GeneCardsiPITPNA
HGNCiHGNC:9001 PITPNA
HPAiHPA000528
MIMi600174 gene
neXtProtiNX_Q00169
OpenTargetsiENSG00000174238
PharmGKBiPA33335
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3668 Eukaryota
COG5083 LUCA
GeneTreeiENSGT00760000119216
HOVERGENiHBG058915
InParanoidiQ00169
OMAiETWHKSD
PhylomeDBiQ00169
TreeFamiTF313279

Enzyme and pathway databases

ReactomeiR-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Miscellaneous databases

ChiTaRSiPITPNA human
EvolutionaryTraceiQ00169
GeneWikiiPhosphatidylinositol_transfer_protein,_alpha
GenomeRNAii5306
PROiPR:Q00169
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174238 Expressed in 231 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_PITPNA
ExpressionAtlasiQ00169 baseline and differential
GenevisibleiQ00169 HS

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR001666 PI_transfer
IPR023393 START-like_dom_sf
PANTHERiPTHR10658 PTHR10658, 1 hit
PfamiView protein in Pfam
PF02121 IP_trans, 1 hit
PRINTSiPR00391 PITRANSFER
ProtoNetiSearch...

Entry informationi

Entry nameiPIPNA_HUMAN
AccessioniPrimary (citable) accession number: Q00169
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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