PITPNA

Functionⁱ

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	58	Phosphatidylinositol lipid headgroup1 Publication	1
Binding siteⁱ	60	Phosphatidylinositol lipid headgroup1 Publication	1
Binding siteⁱ	85	Phosphatidylinositol lipid headgroup1 Publication	1
Binding siteⁱ	89	Phosphatidylinositol lipid headgroup1 Publication	1
Binding siteⁱ	96	Phosphatidylinositol lipid headgroup1 Publication	1
Binding siteⁱ	194	Phosphatidylinositol lipid headgroup1 Publication	1

GO - Molecular functionⁱ

phosphatidylcholine binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224
- 22822086
phosphatidylcholine transporter activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224
- 22822086
phosphatidylglycerol binding
Source: BHF-UCL
Traceable author statementⁱ
- 22822086
phosphatidylinositol binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224
- 22822086
phosphatidylinositol transporter activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224
- 22822086

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axonogenesis Source: Ensembl
interleukin-12-mediated signaling pathway Source: Reactome
lipid metabolic process
Source: ProtInc
Non-traceable author statementⁱ
- 8194769
phospholipid transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224
- 22822086
visual perception
Source: ProtInc
Traceable author statementⁱ
- 7914867

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418890 Role of second messengers in netrin-1 signaling R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Reactomeⁱ

R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Chemistry databases

SwissLipidsⁱ	SLP:000000415

SwissLipidsⁱ

SLP:000000415

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphatidylinositol transfer protein alpha isoform Short name: PI-TP-alpha Short name: PtdIns transfer protein alpha Short name: PtdInsTP alpha
Gene namesⁱ	Name:PITPNA Synonyms:PITPN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174238.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9001 PITPNA
MIMⁱ	600174 gene
neXtProtⁱ	NX_Q00169

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5306
Open Targets More...OpenTargetsⁱ	ENSG00000174238
PharmGKBⁱ	PA33335

Polymorphism and mutation databases

BioMutaⁱ	PITPNA

BioMutaⁱ

PITPNA

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191639	1 – 270	Phosphatidylinositol transfer protein alpha isoformAdd BLAST		270

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	215	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q00169
PaxDbⁱ	Q00169
PeptideAtlas More...PeptideAtlasⁱ	Q00169
PRIDEⁱ	Q00169
ProteomicsDBⁱ	57841

PTM databases

iPTMnetⁱ	Q00169
PhosphoSitePlusⁱ	Q00169

Expressionⁱ

Tissue specificityⁱ

Expressed in a wide range of tissues.

Gene expression databases

Bgeeⁱ	ENSG00000174238 Expressed in 231 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_PITPNA
ExpressionAtlasⁱ	Q00169 baseline and differential
Genevisibleⁱ	Q00169 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000528

HPAⁱ

HPA000528

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	111323, 25 interactors
IntActⁱ	Q00169, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q00169
STRINGⁱ	9606.ENSP00000316809

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	3 – 13	Combined sources	11
Helixⁱ	15 – 33	Combined sources	19
Beta strandⁱ	38 – 49	Combined sources	12
Beta strandⁱ	54 – 65	Combined sources	12
Helixⁱ	70 – 73	Combined sources	4
Beta strandⁱ	81 – 90	Combined sources	10
Beta strandⁱ	93 – 99	Combined sources	7
Helixⁱ	101 – 103	Combined sources	3
Beta strandⁱ	106 – 120	Combined sources	15
Turnⁱ	123 – 126	Combined sources	4
Helixⁱ	130 – 133	Combined sources	4
Beta strandⁱ	137 – 141	Combined sources	5
Helixⁱ	146 – 148	Combined sources	3
Helixⁱ	151 – 153	Combined sources	3
Helixⁱ	156 – 158	Combined sources	3
Helixⁱ	160 – 162	Combined sources	3
Turnⁱ	166 – 168	Combined sources	3
Helixⁱ	177 – 182	Combined sources	6
Beta strandⁱ	190 – 200	Combined sources	11
Turnⁱ	203 – 205	Combined sources	3
Helixⁱ	206 – 230	Combined sources	25
Helixⁱ	232 – 235	Combined sources	4
Helixⁱ	240 – 260	Combined sources	21

Show more details

3D structure databases

ProteinModelPortalⁱ	Q00169
SMRⁱ	Q00169
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q00169

EvolutionaryTraceⁱ

Q00169

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3668 Eukaryota COG5083 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119216
HOVERGENⁱ	HBG058915
InParanoidⁱ	Q00169
OMAⁱ	ETWHKSD
PhylomeDBⁱ	Q00169
TreeFamⁱ	TF313279

Family and domain databases

Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR001666 PI_transfer IPR023393 START-like_dom_sf
PANTHERⁱ	PTHR10658 PTHR10658, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02121 IP_trans, 1 hit
PRINTSⁱ	PR00391 PITRANSFER

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show all Align All

Q00169-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK 
        60         70         80         90        100
DGEKGQYTHK IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN 
       110        120        130        140        150
EYMKEDFLIK IETWHKPDLG TQENVHKLEP EAWKHVEAVY IDIADRSQVL 
       160        170        180        190        200
SKDYKAEEDP AKFKSIKTGR GPLGPNWKQE LVNQKDCPYM CAYKLVTVKF 
       210        220        230        240        250
KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM DDIRRMEEET 
       260        270
KRQLDEMRQK DPVKGMTADD

Length:270

Mass (Da):31,806

Last modified:January 23, 2007 - v2

Checksum:ⁱ4531E6E38697C93B

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GWE5	F5GWE5_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein alpha isoform	PITPNA	270	Annotation score:
I3L459	I3L459_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein alpha isoform	PITPNA	142	Annotation score:
I3L4U7	I3L4U7_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein alpha isoform	PITPNA	121	Annotation score:
I3NI10	I3NI10_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein alpha isoform	PITPNA	66	Annotation score:
I3L3W1	I3L3W1_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein alpha isoform	PITPNA	44	Annotation score:
I3L4C0	I3L4C0_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein alpha isoform	PITPNA	115	Annotation score:
I3L2X8	I3L2X8_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein alpha isoform	PITPNA	83	Annotation score:
I3L471	I3L471_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein alpha isoform	PITPNA	98	Annotation score:
I3L4H1	I3L4H1_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein alpha isoform	PITPNA	209	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	45	N → P in BAA06276 (Ref. 2) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M73704 mRNA Translation: AAA36441.1 D30036 mRNA Translation: BAA06276.1 BC082976 mRNA Translation: AAH82976.1 BC045108 mRNA Translation: AAH45108.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45563.1
PIRⁱ	I53775
NCBI Reference Sequences More...RefSeqⁱ	NP_006215.1, NM_006224.3
UniGeneⁱ	Hs.429819

Genome annotation databases

Ensemblⁱ	ENST00000313486; ENSP00000316809; ENSG00000174238
GeneIDⁱ	5306
KEGGⁱ	hsa:5306

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q00169	Epididymis secretory protein Li 36		HUMAN		270	UniRef100_Q00169
PITPNA isoform 1		PANTR		270

Protein	Similar proteins		Species	Score	Length	Source
Q00169	Phosphatidylinositol transfer protein alpha isoform		BOVIN		270	UniRef90_Q00169
Epididymis secretory protein Li 36		HUMAN		270
PITPNA isoform 1		PANTR		270
phosphatidylinositol transfer protein alpha isoform isoform X1		Florida manatee		288
Uncharacterized protein		RHIBE		272
+60

Protein	Similar proteins		Species	Score	Length	Source
Q00169	Phosphatidylinositol transfer protein alpha isoform		BOVIN		270	UniRef50_Q00169
Epididymis secretory protein Li 36		HUMAN		270
PITPNA isoform 1		PANTR		270
phosphatidylinositol transfer protein alpha isoform isoform X1		Florida manatee		288
Uncharacterized protein		RHIBE		272
+345

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M73704 mRNA Translation: AAA36441.1 D30036 mRNA Translation: BAA06276.1 BC082976 mRNA Translation: AAH82976.1 BC045108 mRNA Translation: AAH45108.1
CCDSⁱ	CCDS45563.1
PIRⁱ	I53775
RefSeqⁱ	NP_006215.1, NM_006224.3
UniGeneⁱ	Hs.429819

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1UW5	X-ray	2.90	A/B/C/D	1-270	[»]
ProteinModelPortalⁱ	Q00169
SMRⁱ	Q00169
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111323, 25 interactors
IntActⁱ	Q00169, 7 interactors
MINTⁱ	Q00169
STRINGⁱ	9606.ENSP00000316809

Chemistry databases

SwissLipidsⁱ	SLP:000000415

SwissLipidsⁱ

SLP:000000415

PTM databases

iPTMnetⁱ	Q00169
PhosphoSitePlusⁱ	Q00169

Polymorphism and mutation databases

BioMutaⁱ	PITPNA

BioMutaⁱ

PITPNA

Proteomic databases

EPDⁱ	Q00169
PaxDbⁱ	Q00169
PeptideAtlasⁱ	Q00169
PRIDEⁱ	Q00169
ProteomicsDBⁱ	57841

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5306
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000313486; ENSP00000316809; ENSG00000174238
GeneIDⁱ	5306
KEGGⁱ	hsa:5306

Organism-specific databases

CTDⁱ	5306
DisGeNETⁱ	5306
EuPathDBⁱ	HostDB:ENSG00000174238.14
GeneCardsⁱ	PITPNA
HGNCⁱ	HGNC:9001 PITPNA
HPAⁱ	HPA000528
MIMⁱ	600174 gene
neXtProtⁱ	NX_Q00169
OpenTargetsⁱ	ENSG00000174238
PharmGKBⁱ	PA33335
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3668 Eukaryota COG5083 LUCA
GeneTreeⁱ	ENSGT00760000119216
HOVERGENⁱ	HBG058915
InParanoidⁱ	Q00169
OMAⁱ	ETWHKSD
PhylomeDBⁱ	Q00169
TreeFamⁱ	TF313279

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418890 Role of second messengers in netrin-1 signaling R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Reactomeⁱ

R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Miscellaneous databases

ChiTaRSⁱ	PITPNA human
EvolutionaryTraceⁱ	Q00169
GeneWikiⁱ	Phosphatidylinositol_transfer_protein,_alpha
GenomeRNAiⁱ	5306
Protein Ontology More...PROⁱ	PR:Q00169
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000174238 Expressed in 231 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_PITPNA
ExpressionAtlasⁱ	Q00169 baseline and differential
Genevisibleⁱ	Q00169 HS

Family and domain databases

Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR001666 PI_transfer IPR023393 START-like_dom_sf
PANTHERⁱ	PTHR10658 PTHR10658, 1 hit
Pfamⁱ	View protein in Pfam PF02121 IP_trans, 1 hit
PRINTSⁱ	PR00391 PITRANSFER
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PIPNA_HUMAN
Accessionⁱ	Q00169Primary (citable) accession number: Q00169
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q00169 (PIPNA_HUMAN)

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Phosphatidylinositol transfer protein alpha isoform

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ