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UniProtKB - Q00169 (PIPNA_HUMAN)

Entry version 187 (07 Apr 2021)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Phosphatidylinositol transfer protein alpha isoform

Gene

PITPNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:10531358, PubMed:22822086, PubMed:15522822, PubMed:18636990, PubMed:14962392). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed:15522822, PubMed:22822086). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (PubMed:22822086).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Phosphatidylinositol transfer activity is inhibited by N-ethylmaleimide.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei58Phosphatidylinositol1 Publication1
Binding sitei60Phosphatidylinositol1 Publication1
Binding sitei85Phosphatidylinositol1 Publication1
Binding sitei89Phosphatidylinositol1 Publication1
Binding sitei96Phosphatidylinositol1 Publication1
Binding sitei194Phosphatidylinositol1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q00169

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418890, Role of second messengers in netrin-1 signaling
R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000415

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol transfer protein alpha isoform
Short name:
PI-TP-alpha
Short name:
PtdIns transfer protein alpha
Short name:
PtdInsTP alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PITPNA
Synonyms:PITPN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9001, PITPNA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600174, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q00169

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000174238.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58T → A: Reduced phosphatidylinositol and phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi58T → E: Complete loss of phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi58T → S: Reduced phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi60K → A: Complete loss of phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi85E → A: Reduced phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi85E → Q: Reduced phosphatidylinositol and phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi89N → F or L: Significant loss of phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi94C → A or T: No effect on phosphatidylinositol transfer activity. Resistant to inhibition by N-ethylmaleimide. 1 Publication1
Mutagenesisi102Y → A: Reduced phosphatidylinositol and phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi187C → A: No effect on phosphatidylinositol transfer activity. 1 Publication1
Mutagenesisi202 – 203WW → AA: Significant loss of phosphatidylinositol and phosphatidylcholine transfer activity. 2 Publications2

Organism-specific databases

DisGeNET

More...DisGeNETi		5306

Open Targets

More...OpenTargetsi		ENSG00000174238

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33335

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q00169, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB03690, (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
DB02144, 1,2-diacyl-sn-glycero-3-phosphoinositol

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PITPNA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001916392 – 270Phosphatidylinositol transfer protein alpha isoformAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei215N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q00169

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q00169

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q00169

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q00169

PeptideAtlas

More...PeptideAtlasi		Q00169

PRoteomics IDEntifications database

More...PRIDEi		Q00169

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57841

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q00169

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q00169

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q00169

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174238, Expressed in pigmented layer of retina and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q00169, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q00169, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000174238, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111323, 27 interactors

Protein interaction database and analysis system

More...IntActi		Q00169, 13 interactors

Molecular INTeraction database

More...MINTi		Q00169

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000316809

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q00169, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q00169

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q00169

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3668, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157119

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_046509_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q00169

Identification of Orthologs from Complete Genome Data

More...OMAi		RTAFQNE

Database of Orthologous Groups

More...OrthoDBi		951268at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q00169

TreeFam database of animal gene trees

More...TreeFami		TF313279

Family and domain databases

Database of protein disorder

More...DisProti		DP02327

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001666, PI_transfer
IPR023393, START-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR10658, PTHR10658, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02121, IP_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00391, PITRANSFER

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q00169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK 
        60         70         80         90        100
DGEKGQYTHK IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN 
       110        120        130        140        150
EYMKEDFLIK IETWHKPDLG TQENVHKLEP EAWKHVEAVY IDIADRSQVL 
       160        170        180        190        200
SKDYKAEEDP AKFKSIKTGR GPLGPNWKQE LVNQKDCPYM CAYKLVTVKF 
       210        220        230        240        250
KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM DDIRRMEEET 
       260        270
KRQLDEMRQK DPVKGMTADD
Length:270
Mass (Da):31,806
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4531E6E38697C93B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4U7I3L4U7_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWE5F5GWE5_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
270Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4C0I3L4C0_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2X8I3L2X8_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4H1I3L4H1_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3W1I3L3W1_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI10I3NI10_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L459I3L459_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L471I3L471_HUMAN
Phosphatidylinositol transfer prote...
PITPNA
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45N → P in BAA06276 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M73704 mRNA Translation: AAA36441.1
D30036 mRNA Translation: BAA06276.1
BC082976 mRNA Translation: AAH82976.1
BC045108 mRNA Translation: AAH45108.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45563.1

Protein sequence database of the Protein Information Resource

More...PIRi		I53775

NCBI Reference Sequences

More...RefSeqi		NP_006215.1, NM_006224.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313486; ENSP00000316809; ENSG00000174238

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5306

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5306

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73704 mRNA Translation: AAA36441.1
D30036 mRNA Translation: BAA06276.1
BC082976 mRNA Translation: AAH82976.1
BC045108 mRNA Translation: AAH45108.1
CCDSiCCDS45563.1
PIRiI53775
RefSeqiNP_006215.1, NM_006224.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UW5X-ray2.90A/B/C/D1-270[»]
SMRiQ00169
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111323, 27 interactors
IntActiQ00169, 13 interactors
MINTiQ00169
STRINGi9606.ENSP00000316809

Chemistry databases

DrugBankiDB03690, (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
DB02144, 1,2-diacyl-sn-glycero-3-phosphoinositol
SwissLipidsiSLP:000000415

PTM databases

iPTMnetiQ00169
MetOSiteiQ00169
PhosphoSitePlusiQ00169

Genetic variation databases

BioMutaiPITPNA

Proteomic databases

EPDiQ00169
jPOSTiQ00169
MassIVEiQ00169
PaxDbiQ00169
PeptideAtlasiQ00169
PRIDEiQ00169
ProteomicsDBi57841

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		5311, 183 antibodies

The DNASU plasmid repository

More...DNASUi		5306

Genome annotation databases

EnsembliENST00000313486; ENSP00000316809; ENSG00000174238
GeneIDi5306
KEGGihsa:5306

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5306
DisGeNETi5306

GeneCards: human genes, protein and diseases

More...GeneCardsi		PITPNA
HGNCiHGNC:9001, PITPNA
HPAiENSG00000174238, Low tissue specificity
MIMi600174, gene
neXtProtiNX_Q00169
OpenTargetsiENSG00000174238
PharmGKBiPA33335
VEuPathDBiHostDB:ENSG00000174238.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3668, Eukaryota
GeneTreeiENSGT00940000157119
HOGENOMiCLU_046509_0_0_1
InParanoidiQ00169
OMAiRTAFQNE
OrthoDBi951268at2759
PhylomeDBiQ00169
TreeFamiTF313279

Enzyme and pathway databases

PathwayCommonsiQ00169
ReactomeiR-HSA-418890, Role of second messengers in netrin-1 signaling
R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5306, 7 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PITPNA, human
EvolutionaryTraceiQ00169

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Phosphatidylinositol_transfer_protein,_alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5306
PharosiQ00169, Tbio

Protein Ontology

More...PROi		PR:Q00169
RNActiQ00169, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174238, Expressed in pigmented layer of retina and 246 other tissues
ExpressionAtlasiQ00169, baseline and differential
GenevisibleiQ00169, HS

Family and domain databases

DisProtiDP02327
Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR001666, PI_transfer
IPR023393, START-like_dom_sf
PANTHERiPTHR10658, PTHR10658, 1 hit
PfamiView protein in Pfam
PF02121, IP_trans, 1 hit
PRINTSiPR00391, PITRANSFER

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIPNA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00169
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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