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UniProtKB - Q00168 (KCC2A_DROME)

Entry version 164 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Calcium/calmodulin-dependent protein kinase type II alpha chain

Gene

CaMKII

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

CASK plays a role in regulation of CaMKII autophosphorylation. When complexed with CASK and in the presence Ca[2+]/CaM, autophosphorylation of Thr-287 causes constitutive activation of the kinase. In the absence of Ca[2+]/CaM, autophosphorylation of Thr-306 causes inactivation of the kinase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei43ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 28ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.17 1994

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-3371571 HSF1-dependent transactivation
R-DME-4086398 Ca2+ pathway
R-DME-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-DME-5578775 Ion homeostasis
R-DME-5673000 RAF activation
R-DME-936837 Ion transport by P-type ATPases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q00168

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type II alpha chain (EC:2.7.11.17)
Short name:
CaM-kinase II alpha chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CaMKII
Synonyms:CaM
ORF Names:CG18069
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0264607 CaMKII

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi306T → A: Fails to interact with CASK, catalytically active but fails to autophosphorylate, when associated with A-307. 1 Publication1
Mutagenesisi306T → D: Fails to interact with CASK, kinase inactive, when associated with D-307. 1 Publication1
Mutagenesisi306T → S: Fails to interact with CASK, catalytically active and can autophosphorylate, when associated with S-307. 1 Publication1
Mutagenesisi307T → A: Fails to interact with CASK, catalytically active but fails to autophosphorylate, when associated with A-306. 1 Publication1
Mutagenesisi307T → D: Fails to interact with CASK, kinase inactive, when associated with D-306. 1 Publication1
Mutagenesisi307T → S: Fails to interact with CASK, catalytically active and can autophosphorylate, when associated with S-306. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000860951 – 530Calcium/calmodulin-dependent protein kinase type II alpha chainAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei287Phosphothreonine; by autocatalysis2 Publications1
Modified residuei306Phosphothreonine; by autocatalysis1 Publication1
Modified residuei307Phosphothreonine; by autocatalysis1 Publication1
Modified residuei327Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylation at Thr-287 is independent of autophosphorylation at Thr-306 and Thr-307.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q00168

PRoteomics IDEntifications database

More...PRIDEi		Q00168

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q00168

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at a high level in the central nervous system during the late embryonic stage. In adults, expression is more abundant in the head than in the body.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0264607 Expressed in 50 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q00168 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q00168 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CASK.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CASKQ242105EBI-124595,EBI-214423

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		68654, 30 interactors

Protein interaction database and analysis system

More...IntActi		Q00168, 5 interactors

Molecular INTeraction database

More...MINTi		Q00168

STRING: functional protein association networks

More...STRINGi		7227.FBpp0289608

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FG8X-ray1.96A1-283[»]
5H9BX-ray2.25A1-283[»]
5HU3X-ray1.89A1-283[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q00168

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q00168

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 272Protein kinasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni291 – 301Calmodulin-bindingAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0033 Eukaryota
ENOG410XNRX LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159769

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q00168

KEGG Orthology (KO)

More...KOi		K04515

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q00168

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

More...PANTHERi		PTHR43940 PTHR43940, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00168-1) [UniParc]FASTAAdd to basket
Also known as: 530aa, D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPAACTRF SDNYDIKEEL GKGAFSIVKR CVQKSTGFEF AAKIINTKKL 
        60         70         80         90        100
TARDFQKLER EARICRKLHH PNIVRLHDSI QEENYHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREFYSE ADASHCIQQI LESVNHCHQN GVVHRDLKPE NLLLASKAKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDHQA WFGFAGTPGY LSPEVLKKEP YGKSVDIWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYSQIKAGA YDYPSPEWDT VTPEAKNLIN 
       260        270        280        290        300
QMLTVNPNKR ITAAEALKHP WICQRERVAS VVHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSSRSMI TKKGEGSQVK ESTDSSSTTL EDDDIKEDKK 
       360        370        380        390        400
GTVDRSTTVV SKEPEDIRIL CPAKTYQQNI GNSQCSSARR QEIIKITEQL 
       410        420        430        440        450
IEAINSGDFD GYTKICDPHL TAFEPEALGN LVEGIDFHKF YFENVLGKNC 
       460        470        480        490        500
KAINTTILNP HVHLLGEEAA CIAYVRLTQY IDKQGHAHTH QSEETRVWHK 
       510        520        530
RDNKWQNVHF HRSASAKISG ATTFDFIPQK
Length:530
Mass (Da):59,920
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F3D83582ABDFCFD
GO
Isoform 2 (identifier: Q00168-2) [UniParc]FASTAAdd to basket
Also known as: 516aa, G

The sequence of this isoform differs from the canonical sequence as follows:
     366-387: DIRILCPAKTYQQNIGNSQCSS → VNLFTNKA

Show »
Length:516
Mass (Da):58,386
Checksum:i16D891160BEC6FF2
GO
Isoform 3 (identifier: Q00168-3) [UniParc]FASTAAdd to basket
Also known as: 509aa, B, E

The sequence of this isoform differs from the canonical sequence as follows:
     366-387: DIRILCPAKTYQQNIGNSQCSS → A

Show »
Length:509
Mass (Da):57,569
Checksum:iE148946CEA1E057F
GO
Isoform 4 (identifier: Q00168-4) [UniParc]FASTAAdd to basket
Also known as: 490aa, A, C

The sequence of this isoform differs from the canonical sequence as follows:
     347-386: Missing.
     387-387: S → A

Show »
Length:490
Mass (Da):55,482
Checksum:i17E1972584F9B2C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4V133A4V133_DROME
Calcium/calmodulin-dependent protei...
CaMKII Ca2+, Calcium, calcium, CaM, Cam
490Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L0MNA2L0MNA2_DROME
Calcium/calmodulin-dependent protei...
CaMKII Ca2+, Calcium, calcium, CaM, Cam
482Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D1YSG7D1YSG7_DROME
Calcium/calmodulin-dependent protei...
CaMKII Ca2+, Calcium, calcium, CaM, Cam
530Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4V134A4V134_DROME
Calcium/calmodulin-dependent protei...
CaMKII Ca2+, Calcium, calcium, CaM, Cam
509Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D1YSG8D1YSG8_DROME
Calcium/calmodulin-dependent protei...
CaMKII Ca2+, Calcium, calcium, CaM, Cam
531Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L0MLR4L0MLR4_DROME
Calcium/calmodulin-dependent protei...
CaMKII Ca2+, Calcium, calcium, CaM, Cam
522Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L0MLP2L0MLP2_DROME
Calcium/calmodulin-dependent protei...
CaMKII Ca2+, Calcium, calcium, CaM, Cam
504Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti388A → S in AAB28246 (PubMed:1910789).Curated1
Sequence conflicti388A → S in AAB28248 (PubMed:1910789).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050261347 – 386Missing in isoform 4. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_050262366 – 387DIRIL…SQCSS → VNLFTNKA in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_050263366 – 387DIRIL…SQCSS → A in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_050264387S → A in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D13330 mRNA Translation: BAA02593.1
D13331 mRNA Translation: BAA02594.1
D13332 mRNA Translation: BAA02595.1
D13333 mRNA Translation: BAA02596.1
M74583 mRNA Translation: AAA51459.1
AE014135 Genomic DNA Translation: AAF59388.3
AE014135 Genomic DNA Translation: AAF59390.2
AE014135 Genomic DNA Translation: AAN06568.2
AE014135 Genomic DNA Translation: AAX53595.1
S65712 mRNA Translation: AAB28244.1
S65716 mRNA Translation: AAB28245.1
S65717 mRNA Translation: AAB28246.2
S65719 mRNA Translation: AAB28247.1
S65724 mRNA Translation: AAB28248.2

Protein sequence database of the Protein Information Resource

More...PIRi		B44412
C44412 JU0270
D44412

NCBI Reference Sequences

More...RefSeqi		NP_001014696.1, NM_001014696.2 [Q00168-2]
NP_001162831.1, NM_001169360.2 [Q00168-4]
NP_001162832.1, NM_001169361.2 [Q00168-1]
NP_524635.3, NM_079896.4 [Q00168-4]
NP_726633.2, NM_166810.5 [Q00168-4]
NP_726634.1, NM_166811.2 [Q00168-3]
NP_726635.2, NM_166812.3 [Q00168-1]
NP_726636.2, NM_166813.3 [Q00168-3]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Dm.1709

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0089217; FBpp0088281; FBgn0264607 [Q00168-4]
FBtr0089218; FBpp0088282; FBgn0264607 [Q00168-4]
FBtr0089219; FBpp0088283; FBgn0264607 [Q00168-3]
FBtr0100146; FBpp0099496; FBgn0264607 [Q00168-1]
FBtr0100147; FBpp0099497; FBgn0264607 [Q00168-3]
FBtr0100148; FBpp0099498; FBgn0264607 [Q00168-2]
FBtr0300377; FBpp0289606; FBgn0264607 [Q00168-4]
FBtr0300378; FBpp0289607; FBgn0264607 [Q00168-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		43828

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG18069

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Calmodulin-dependent kinase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13330 mRNA Translation: BAA02593.1
D13331 mRNA Translation: BAA02594.1
D13332 mRNA Translation: BAA02595.1
D13333 mRNA Translation: BAA02596.1
M74583 mRNA Translation: AAA51459.1
AE014135 Genomic DNA Translation: AAF59388.3
AE014135 Genomic DNA Translation: AAF59390.2
AE014135 Genomic DNA Translation: AAN06568.2
AE014135 Genomic DNA Translation: AAX53595.1
S65712 mRNA Translation: AAB28244.1
S65716 mRNA Translation: AAB28245.1
S65717 mRNA Translation: AAB28246.2
S65719 mRNA Translation: AAB28247.1
S65724 mRNA Translation: AAB28248.2
PIRiB44412
C44412 JU0270
D44412
RefSeqiNP_001014696.1, NM_001014696.2 [Q00168-2]
NP_001162831.1, NM_001169360.2 [Q00168-4]
NP_001162832.1, NM_001169361.2 [Q00168-1]
NP_524635.3, NM_079896.4 [Q00168-4]
NP_726633.2, NM_166810.5 [Q00168-4]
NP_726634.1, NM_166811.2 [Q00168-3]
NP_726635.2, NM_166812.3 [Q00168-1]
NP_726636.2, NM_166813.3 [Q00168-3]
UniGeneiDm.1709

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FG8X-ray1.96A1-283[»]
5H9BX-ray2.25A1-283[»]
5HU3X-ray1.89A1-283[»]
ProteinModelPortaliQ00168
SMRiQ00168
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68654, 30 interactors
IntActiQ00168, 5 interactors
MINTiQ00168
STRINGi7227.FBpp0289608

PTM databases

iPTMnetiQ00168

Proteomic databases

PaxDbiQ00168
PRIDEiQ00168

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089217; FBpp0088281; FBgn0264607 [Q00168-4]
FBtr0089218; FBpp0088282; FBgn0264607 [Q00168-4]
FBtr0089219; FBpp0088283; FBgn0264607 [Q00168-3]
FBtr0100146; FBpp0099496; FBgn0264607 [Q00168-1]
FBtr0100147; FBpp0099497; FBgn0264607 [Q00168-3]
FBtr0100148; FBpp0099498; FBgn0264607 [Q00168-2]
FBtr0300377; FBpp0289606; FBgn0264607 [Q00168-4]
FBtr0300378; FBpp0289607; FBgn0264607 [Q00168-1]
GeneIDi43828
KEGGidme:Dmel_CG18069

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		43828
FlyBaseiFBgn0264607 CaMKII

Phylogenomic databases

eggNOGiKOG0033 Eukaryota
ENOG410XNRX LUCA
GeneTreeiENSGT00940000159769
InParanoidiQ00168
KOiK04515
PhylomeDBiQ00168

Enzyme and pathway databases

BRENDAi2.7.11.17 1994
ReactomeiR-DME-3371571 HSF1-dependent transactivation
R-DME-4086398 Ca2+ pathway
R-DME-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-DME-5578775 Ion homeostasis
R-DME-5673000 RAF activation
R-DME-936837 Ion transport by P-type ATPases
SignaLinkiQ00168

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		43828

Protein Ontology

More...PROi		PR:Q00168

Gene expression databases

BgeeiFBgn0264607 Expressed in 50 organ(s), highest expression level in head
ExpressionAtlasiQ00168 baseline and differential
GenevisibleiQ00168 DM

Family and domain databases

InterProiView protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43940 PTHR43940, 1 hit
PfamiView protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCC2A_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00168
Secondary accession number(s): Q59DP1, Q59DP2, Q9V495
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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