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Entry version 52 (11 Dec 2019)
Sequence version 1 (01 Dec 1992)
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Protein

Probable major glycoprotein

Gene

ORF46

Organism
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable major glycoprotein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ORF46
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiIctalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri766178 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesAlloherpesviridaeIctalurivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiIctaluridae (bullhead catfishes) [TaxID: 7996]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007643 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1308 – 1328HelicalSequence analysisAdd BLAST21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022212817 – 1355Probable major glycoproteinAdd BLAST1339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi81N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi129N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi542N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi655N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi682N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi744N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi811N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi815N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi860N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi865N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi882N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi895N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1213N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1225N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1267N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1274N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q00104

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1245 – 1299Sequence analysisAdd BLAST55

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q00104-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKTMLAIIL IPLVYAVAGE TVADDEVFFL SAPQLDGTLI DSWGTDAVIT
60 70 80 90 100
GSTLMNRLWK TFTVSATHTL REYGRVAKSV NSTAATKCTH LCVPGTVLKL
110 120 130 140 150
SVQATRSNAN NNASWRFARP VITNMHELNE TCIPMEYDCE EVISEKTSLN
160 170 180 190 200
TLSITIYGSN DLKKALGENS TCNKTWTQGC AIATALTALY ENKSVDARKL
210 220 230 240 250
NILRGTSYTC LLGYLGIGEL EPNSPCWTQL GPMCYGPLAE QVCVTAGRNP
260 270 280 290 300
FGVVPRADRP VSTGVDCRVG SRADLQFSGL TKGLFAERGC DRVFVRCDLI
310 320 330 340 350
DPYDPPATAA EFELHVECRS SFRVSGFPGE GEDMGLELAF NNFGLEGLIR
360 370 380 390 400
TKQDRLTIIT GIFDIRNNKY NALVINWIPT PELLDTFHMF MAELDTFRKI
410 420 430 440 450
HRPTVRLGVV ITGASPFVEQ YNFKLLSGVV DMVYIHPQIQ PMTSTPTLTC
460 470 480 490 500
PMPIRSDSLE CGEPHRQCPG FDGYRHLTYA TRFLLGHISP EKLTLGLDVS
510 520 530 540 550
CQLWGRRVRQ YDTNWYFQDN LFSEVQGGWV SRGYITDVIQ PNMTQAIQLN
560 570 580 590 600
GCHGVFGPEL DILLPSADAT PYVGLLWSQP SDLEDAVDFS MALGITRFSI
610 620 630 640 650
EGALGDVYMD SSENLKTVST VHEAVTVRMR AHAMMEEMLG EGGLAAFDES
660 670 680 690 700
MIWANVTRST GTATTGARKR RALTTQGPDG VNRTIPFSAS VQSGTSIVRI
710 720 730 740 750
GTGPKMVCPG IIASVRGLLF SRTSYQGFYR LTFFQNLYVT QLQNLTGCTA
760 770 780 790 800
VKPEDLPVIT QATKVPSVFA IDINTFGVVN GSEYYVVGLE GTDLVQYSPQ
810 820 830 840 850
VKQSCAFINT NETFNQTFIT IDERFFFTGP RPVADGFVIP AGINFFGSDN
860 870 880 890 900
IMTVDYIDFN VTCMNYSNPS VQSCIATVCA ANVTECTPRA TLLCNQTAAI
910 920 930 940 950
LLDFQRSNEL LKNSLVDLDL EHEKVKMFAP ASGGSVPTSD KFGLSVAAIT
960 970 980 990 1000
MSSAALVAST AALAVATLAA SKIDGLQAQL DKTADVITEL GDSIALISAK
1010 1020 1030 1040 1050
LDRNIRAVNG RVDDLQNQIN LQMLAMDTNF KRLATGLKEL GTTTNERLGE
1060 1070 1080 1090 1100
VMAYQQWYQQ IMSLTNQVTQ GAIQIGYKVG MIRTCVKSLL AGTMAGCPTD
1110 1120 1130 1140 1150
ASSFRDHPGL TFRKTVRALL YRDQKLFIVN EVPQTLTARS VQVFIPSPTI
1160 1170 1180 1190 1200
TEKKVCWPDY KLMHVDGKVV APLECTGKYC SEPIEATDYQ ECLTNPSTCR
1210 1220 1230 1240 1250
YVCGDCYRGI CYNRTTEDIS IKFENVTHAL SVSDLTSPLF NSIPQIVSME
1260 1270 1280 1290 1300
MEIQDLKLEL IQLQKINTSV HMENITGDID AMKATIEEYR AEMAKLRVTG
1310 1320 1330 1340 1350
FGEWLKYFIY AILGVIAIGA LIAIIFMAVK CYQARALLSM TAYQPVPTRP

MGMMY
Length:1,355
Mass (Da):149,120
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95E65A99E974CF63
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M75136 Genomic DNA Translation: AAA88149.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B36791 VGBEI1

NCBI Reference Sequences

More...
RefSeqi
NP_041137.1, NC_001493.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1488406

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1488406

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75136 Genomic DNA Translation: AAA88149.1
PIRiB36791 VGBEI1
RefSeqiNP_041137.1, NC_001493.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ00104

Genome annotation databases

GeneIDi1488406
KEGGivg:1488406

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVG46_ICHVA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00104
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: December 11, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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