TFAM

Functionⁱ

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.7 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	58	Intercalates between bases and promotes DNA bending		1
Siteⁱ	182	Intercalates between bases and promotes DNA bending		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	50 – 118	HMG box 1PROSITE-ProRule annotationAdd BLAST		69
DNA bindingⁱ	155 – 219	HMG box 2PROSITE-ProRule annotationAdd BLAST		65

GO - Molecular functionⁱ

chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18063578
DNA binding, bending
Source: UniProtKB
Inferred from direct assayⁱ
- 22037171
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22037171
heat shock protein binding Source: Ensembl
mitochondrial promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19304746
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 29445193
transcription coactivator binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial respiratory chain complex assembly Source: Ensembl
mitochondrial transcription
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22037171
mitochondrion organization Source: Reactome
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 20410300
transcription initiation from mitochondrial promoter
Source: UniProtKB
Inferred from direct assayⁱ
- 20410300

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163282 Mitochondrial transcription initiation R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
SIGNORⁱ	Q00059

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor A, mitochondrial Short name: mtTFA Alternative name(s): Mitochondrial transcription factor 1 Short name: MtTF1 Transcription factor 6 Short name: TCF-6 Transcription factor 6-like 2
Gene namesⁱ	Name:TFAM Synonyms:TCF6, TCF6L2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108064.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11741 TFAM
MIMⁱ	600438 gene
neXtProtⁱ	NX_Q00059

Keywords - Cellular componentⁱ

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mitochondrial DNA depletion syndrome 15, hepatocerebral type (MTDPS15)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive mitochondrial disorder characterized by severe intrauterine growth restriction, neonatal-onset hypoglycemia and liver dysfunction, mitochondrial DNA depletion in liver and skeletal muscle, and abnormal mitochondrial morphology observed in skeletal muscle. Hepatic pathology includes cirrhosis, steatosis and cholestasis. Progression to liver failure and death is rapid with no evidence of neurological impairment or other organ involvement.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_077842	178	P → L in MTDPS15. 1 PublicationCorresponds to variant dbSNP:rs757075712EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	77	T → A: Moderate reduction in DNA bending. 1 Publication		1
Mutagenesisⁱ	162	Y → A: Moderate reduction in DNA bending. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7019
MalaCards human disease database More...MalaCardsⁱ	TFAM
MIMⁱ	617156 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000108064
PharmGKBⁱ	PA36458

Polymorphism and mutation databases

DMDMⁱ	417324

DMDMⁱ

417324

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 42	MitochondrionSequence analysisCombined sourcesAdd BLAST		42
ChainⁱPRO_0000013470	43 – 246	Transcription factor A, mitochondrialAdd BLAST		204

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	55	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	56	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	61	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	122	PhosphothreonineCombined sources	1
Modified residueⁱ	160	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	193	PhosphoserineCombined sources	1
Modified residueⁱ	195	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q00059
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q00059
PaxDbⁱ	Q00059
PeptideAtlas More...PeptideAtlasⁱ	Q00059
PRIDEⁱ	Q00059
ProteomicsDBⁱ	57840
TopDownProteomicsⁱ	Q00059-1 [Q00059-1]

PTM databases

iPTMnetⁱ	Q00059
PhosphoSitePlusⁱ	Q00059

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000108064 Expressed in 229 organ(s), highest expression level in female gonad
CleanExⁱ	HS_TFAM
ExpressionAtlasⁱ	Q00059 baseline and differential
Genevisibleⁱ	Q00059 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040648 HPA063684

HPAⁱ

HPA040648
HPA063684

Interactionⁱ

Subunit structureⁱ

Monomer; binds DNA as a monomer. Upon metabolic stress, forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (PubMed:29445193). Interacts with TFB1M and TFB2M. Interacts with CLPX; this enhances DNA-binding.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AGTRAP	Q6RW13	3	EBI-1049924,EBI-741181
ARL6IP1	Q15041	3	EBI-1049924,EBI-714543
MGST3	O14880	3	EBI-1049924,EBI-724754
TFB1M	Q8WVM0	2	EBI-1049924,EBI-2615570

GO - Molecular functionⁱ

heat shock protein binding Source: Ensembl
transcription coactivator binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112877, 30 interactors
IntActⁱ	Q00059, 32 interactors
Molecular INTeraction database More...MINTⁱ	Q00059
STRINGⁱ	9606.ENSP00000420588

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	45 – 48	Combined sources	4
Helixⁱ	56 – 71	Combined sources	16
Beta strandⁱ	73 – 75	Combined sources	3
Helixⁱ	77 – 90	Combined sources	14
Helixⁱ	93 – 120	Combined sources	28
Helixⁱ	123 – 151	Combined sources	29
Helixⁱ	161 – 173	Combined sources	13
Beta strandⁱ	175 – 177	Combined sources	3
Helixⁱ	178 – 190	Combined sources	13
Helixⁱ	194 – 217	Combined sources	24
Helixⁱ	228 – 230	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q00059
SMRⁱ	Q00059
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q00059

EvolutionaryTraceⁱ

Q00059

Family & Domainsⁱ

Domainⁱ

Binds DNA via its HMG boxes. When bound to the mitochondrial light strand promoter, bends DNA into a U-turn shape, each HMG box bending the DNA by 90 degrees.2 Publications

Keywords - Domainⁱ

Repeat, Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG0381 Eukaryota COG5648 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039001
HOGENOMⁱ	HOG000139423
HOVERGENⁱ	HBG106674
InParanoidⁱ	Q00059
KEGG Orthology (KO) More...KOⁱ	K11830
OMAⁱ	KIRYYNE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0SA8
PhylomeDBⁱ	Q00059
TreeFamⁱ	TF318343

Family and domain databases

Gene3Dⁱ	1.10.30.10, 2 hits
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit PF09011 HMG_box_2, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 2 hits
SUPFAMⁱ	SSF47095 SSF47095, 2 hits
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q00059-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFLRSMWGV LSALGRSGAE LCTGCGSRLR SPFSFVYLPR WFSSVLASCP 
        60         70         80         90        100
KKPVSSYLRF SKEQLPIFKA QNPDAKTTEL IRRIAQRWRE LPDSKKKIYQ 
       110        120        130        140        150
DAYRAEWQVY KEEISRFKEQ LTPSQIMSLE KEIMDKHLKR KAMTKKKELT 
       160        170        180        190        200
LLGKPKRPRS AYNVYVAERF QEAKGDSPQE KLKTVKENWK NLSDSEKELY 
       210        220        230        240 
IQHAKEDETR YHNEMKSWEE QMIEVGRKDL LRRTIKKQRK YGAEEC

Length:246

Mass (Da):29,097

Last modified:October 1, 1993 - v1

Checksum:ⁱ81F00CFA12DA4924

GO

Isoform 2 (identifier: Q00059-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
148-179: Missing.

« Hide

        10         20         30         40         50
MAFLRSMWGV LSALGRSGAE LCTGCGSRLR SPFSFVYLPR WFSSVLASCP 
        60         70         80         90        100
KKPVSSYLRF SKEQLPIFKA QNPDAKTTEL IRRIAQRWRE LPDSKKKIYQ 
       110        120        130        140        150
DAYRAEWQVY KEEISRFKEQ LTPSQIMSLE KEIMDKHLKR KAMTKKKEKL 
       160        170        180        190        200
KTVKENWKNL SDSEKELYIQ HAKEDETRYH NEMKSWEEQM IEVGRKDLLR 
       210 
RTIKKQRKYG AEEC

Note: Gene prediction based on EST data.

Show »

Length:214

Mass (Da):25,466

Checksum:ⁱC3802AD446D4764D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7BYN3	H7BYN3_HUMAN		Transcription factor A, mitochondri... Transcription factor A, mitochondrial	TFAM	219	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	34	S → R in CAA45562 (PubMed:1610904).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_016124	12	S → T3 PublicationsCorresponds to variant dbSNP:rs1937Ensembl.		1
Natural variantⁱVAR_077842	178	P → L in MTDPS15. 1 PublicationCorresponds to variant dbSNP:rs757075712EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047019	148 – 179	Missing in isoform 2. CuratedAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M62810 mRNA Translation: AAA59849.1 EU279428 mRNA Translation: ABX72056.1 BT019658 mRNA Translation: AAV38464.1 BT019659 mRNA Translation: AAV38465.1 AK312558 mRNA Translation: BAG35455.1 AB451241 mRNA Translation: BAG70055.1 AB451366 mRNA Translation: BAG70180.1 AC023170 Genomic DNA No translation available. BC126366 mRNA Translation: AAI26367.1 X64269 Genomic DNA Translation: CAA45562.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS59217.1 [Q00059-2] CCDS7253.1 [Q00059-1]
PIRⁱ	JC1496
NCBI Reference Sequences More...RefSeqⁱ	NP_001257711.1, NM_001270782.1 [Q00059-2] NP_003192.1, NM_003201.2 [Q00059-1]
UniGeneⁱ	Hs.594250

Genome annotation databases

Ensemblⁱ	ENST00000373895; ENSP00000363002; ENSG00000108064 [Q00059-2] ENST00000487519; ENSP00000420588; ENSG00000108064 [Q00059-1]
GeneIDⁱ	7019
KEGGⁱ	hsa:7019
UCSC genome browser More...UCSCⁱ	uc001jkf.5 human [Q00059-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q00059	Transcription factor A, mitochondrial		GORGO		278	UniRef100_Q00059
Mitochondrial transcription factor A		HUMAN		246
TFAM isoform 1		PANTR		246
Q00059-2	TFAM isoform 2		PANTR		214	UniRef100_A0A2I3RPQ6
Transcription factor A, mitochondrial		GORGO		214

Protein	Similar proteins		Species	Score	Length	Source
Q00059	Transcription factor A, mitochondrial		GORGO		278	UniRef90_Q00059
Mitochondrial transcription factor A		HUMAN		246
TFAM isoform 1		PANTR		246
Transcription factor A, mitochondrial		PONAB		284
Uncharacterized protein		NOMLE		241
+9
Q00059-2	TFAM isoform 2		PANTR		214	UniRef90_A0A2I3RPQ6
Transcription factor A, mitochondrial		GORGO		214
Uncharacterized protein		COLAP		216
Uncharacterized protein		RHIRO		215
Uncharacterized protein		NOMLE		209

Protein	Similar proteins		Species	Score	Length	Source
Q00059	Transcription factor A, mitochondrial		RAT		244	UniRef50_Q00059
Transcription factor A, mitochondrial		MOUSE		243
Transcription factor A, mitochondrial		PIG		246
Transcription factor A, mitochondrial		BOVIN		246
Transcription factor A, mitochondrial		TRACR		246
+150
Q00059-2	TFAM isoform 2		PANTR		214	UniRef50_A0A2I3RPQ6
Transcription factor A, mitochondrial		GORGO		214
Uncharacterized protein		COLAP		216
Uncharacterized protein		RHIRO		215
Uncharacterized protein		NOMLE		209
+31

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M62810 mRNA Translation: AAA59849.1 EU279428 mRNA Translation: ABX72056.1 BT019658 mRNA Translation: AAV38464.1 BT019659 mRNA Translation: AAV38465.1 AK312558 mRNA Translation: BAG35455.1 AB451241 mRNA Translation: BAG70055.1 AB451366 mRNA Translation: BAG70180.1 AC023170 Genomic DNA No translation available. BC126366 mRNA Translation: AAI26367.1 X64269 Genomic DNA Translation: CAA45562.1
CCDSⁱ	CCDS59217.1 [Q00059-2] CCDS7253.1 [Q00059-1]
PIRⁱ	JC1496
RefSeqⁱ	NP_001257711.1, NM_001270782.1 [Q00059-2] NP_003192.1, NM_003201.2 [Q00059-1]
UniGeneⁱ	Hs.594250

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3FGH	X-ray	1.35	A	153-218	[»]
	3TMM	X-ray	2.50	A	43-246	[»]
	3TQ6	X-ray	2.45	A/B	43-246	[»]
	4NNU	X-ray	2.81	A/B	43-237	[»]
	4NOD	X-ray	2.90	A/B/G/H	43-237	[»]
	6ERP	X-ray	4.50	C/G	43-245	[»]
	6ERQ	X-ray	4.50	C/G	43-245	[»]
ProteinModelPortalⁱ	Q00059
SMRⁱ	Q00059
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112877, 30 interactors
IntActⁱ	Q00059, 32 interactors
MINTⁱ	Q00059
STRINGⁱ	9606.ENSP00000420588

PTM databases

iPTMnetⁱ	Q00059
PhosphoSitePlusⁱ	Q00059

Polymorphism and mutation databases

DMDMⁱ	417324

DMDMⁱ

417324

Proteomic databases

EPDⁱ	Q00059
MaxQBⁱ	Q00059
PaxDbⁱ	Q00059
PeptideAtlasⁱ	Q00059
PRIDEⁱ	Q00059
ProteomicsDBⁱ	57840
TopDownProteomicsⁱ	Q00059-1 [Q00059-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7019
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373895; ENSP00000363002; ENSG00000108064 [Q00059-2] ENST00000487519; ENSP00000420588; ENSG00000108064 [Q00059-1]
GeneIDⁱ	7019
KEGGⁱ	hsa:7019
UCSCⁱ	uc001jkf.5 human [Q00059-1]

Organism-specific databases

CTDⁱ	7019
DisGeNETⁱ	7019
EuPathDBⁱ	HostDB:ENSG00000108064.10
GeneCardsⁱ	TFAM
HGNCⁱ	HGNC:11741 TFAM
HPAⁱ	HPA040648 HPA063684
MalaCardsⁱ	TFAM
MIMⁱ	600438 gene 617156 phenotype
neXtProtⁱ	NX_Q00059
OpenTargetsⁱ	ENSG00000108064
PharmGKBⁱ	PA36458
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0381 Eukaryota COG5648 LUCA
GeneTreeⁱ	ENSGT00440000039001
HOGENOMⁱ	HOG000139423
HOVERGENⁱ	HBG106674
InParanoidⁱ	Q00059
KOⁱ	K11830
OMAⁱ	KIRYYNE
OrthoDBⁱ	EOG091G0SA8
PhylomeDBⁱ	Q00059
TreeFamⁱ	TF318343

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163282 Mitochondrial transcription initiation R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
SIGNORⁱ	Q00059

Miscellaneous databases

ChiTaRSⁱ	TFAM human
EvolutionaryTraceⁱ	Q00059
GeneWikiⁱ	TFAM
GenomeRNAiⁱ	7019
Protein Ontology More...PROⁱ	PR:Q00059
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108064 Expressed in 229 organ(s), highest expression level in female gonad
CleanExⁱ	HS_TFAM
ExpressionAtlasⁱ	Q00059 baseline and differential
Genevisibleⁱ	Q00059 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 2 hits
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit PF09011 HMG_box_2, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 2 hits
SUPFAMⁱ	SSF47095 SSF47095, 2 hits
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TFAM_HUMAN
Accessionⁱ	Q00059Primary (citable) accession number: Q00059 Secondary accession number(s): A8MRB2 , A9QXC6, B5BU05, Q5U0C6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	October 1, 1993
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - Q00059 (TFAM_HUMAN)

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Transcription factor A, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ