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Protein

Homeobox protein Hox-A4

Gene

HOXA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi215 – 274HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • multicellular organism development Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A4
Alternative name(s):
Homeobox protein Hox-1.4
Homeobox protein Hox-1D
Gene namesi
Name:HOXA4
Synonyms:HOX1D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000197576.13
HGNCiHGNC:5105 HOXA4
MIMi142953 gene
neXtProtiNX_Q00056

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3201
OpenTargetsiENSG00000197576
PharmGKBiPA29382

Polymorphism and mutation databases

BioMutaiHOXA4
DMDMi116242514

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000481 – 320Homeobox protein Hox-A4Add BLAST320

Proteomic databases

EPDiQ00056
MaxQBiQ00056
PaxDbiQ00056
PeptideAtlasiQ00056
PRIDEiQ00056
ProteomicsDBi57839

PTM databases

iPTMnetiQ00056
PhosphoSitePlusiQ00056

Expressioni

Tissue specificityi

Embryonic nervous system.

Gene expression databases

BgeeiENSG00000197576 Expressed in 75 organ(s), highest expression level in lower esophagus
CleanExiHS_HOXA4
ExpressionAtlasiQ00056 baseline and differential
GenevisibleiQ00056 HS

Organism-specific databases

HPAiHPA060088

Interactioni

Protein-protein interaction databases

BioGridi109441, 1 interactor
STRINGi9606.ENSP00000353151

Structurei

3D structure databases

ProteinModelPortaliQ00056
SMRiQ00056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi194 – 199Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 192Pro-rich (part of the transcriptional activation domain)Add BLAST178

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiQ00056
KOiK09304
OMAiYYAPRTA
OrthoDBiEOG091G09XD
PhylomeDBiQ00056
TreeFamiTF352857

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q00056-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMSSFLINS NYIEPKFPPF EEYAQHSGSG GADGGPGGGP GYQQPPAPPT
60 70 80 90 100
QHLPLQQPQL PHAGGGREPT ASYYAPRTAR EPAYPAAALY PAHGAADTAY
110 120 130 140 150
PYGYRGGASP GRPPQPEQPP AQAKGPAHGL HASHVLQPQL PPPLQPRAVP
160 170 180 190 200
PAAPRRCEAA PATPGVPAGG SAPACPLLLA DKSPLGLKGK EPVVYPWMKK
210 220 230 240 250
IHVSAVNPSY NGGEPKRSRT AYTRQQVLEL EKEFHFNRYL TRRRRIEIAH
260 270 280 290 300
TLCLSERQVK IWFQNRRMKW KKDHKLPNTK MRSSNSASAS AGPPGKAQTQ
310 320
SPHLHPHPHP STSTPVPSSI
Length:320
Mass (Da):34,499
Last modified:October 17, 2006 - v3
Checksum:iD9B9C98901B06FE4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YHX3H0YHX3_HUMAN
Homeobox protein Hox-A4
HOXA4
140Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108A → P in AAA58664 (PubMed:1675427).Curated1
Sequence conflicti205A → S in AAA53290 (PubMed:2571574).Curated1
Sequence conflicti275 – 276KL → NC in AAA53290 (PubMed:2571574).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03626637G → D in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_02841470T → P1 PublicationCorresponds to variant dbSNP:rs6944345Ensembl.1
Natural variantiVAR_028415140L → P1 PublicationCorresponds to variant dbSNP:rs10251056Ensembl.1
Natural variantiVAR_028416178L → F. Corresponds to variant dbSNP:rs13246088Ensembl.1
Natural variantiVAR_028417251T → P. Corresponds to variant dbSNP:rs6976847Ensembl.1
Natural variantiVAR_028418317P → S. Corresponds to variant dbSNP:rs17500757Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74297 mRNA Translation: AAA58664.1
AC004080 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93872.1
CH236948 Genomic DNA Translation: EAL24224.1
M28199 Genomic DNA Translation: AAA53290.1
CCDSiCCDS5405.1
PIRiA39724
RefSeqiNP_002132.3, NM_002141.4
UniGeneiHs.533357
Hs.721126

Genome annotation databases

EnsembliENST00000360046; ENSP00000353151; ENSG00000197576
ENST00000428284; ENSP00000408845; ENSG00000197576
ENST00000610970; ENSP00000479166; ENSG00000197576
GeneIDi3201
KEGGihsa:3201
UCSCiuc003sym.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74297 mRNA Translation: AAA58664.1
AC004080 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93872.1
CH236948 Genomic DNA Translation: EAL24224.1
M28199 Genomic DNA Translation: AAA53290.1
CCDSiCCDS5405.1
PIRiA39724
RefSeqiNP_002132.3, NM_002141.4
UniGeneiHs.533357
Hs.721126

3D structure databases

ProteinModelPortaliQ00056
SMRiQ00056
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109441, 1 interactor
STRINGi9606.ENSP00000353151

PTM databases

iPTMnetiQ00056
PhosphoSitePlusiQ00056

Polymorphism and mutation databases

BioMutaiHOXA4
DMDMi116242514

Proteomic databases

EPDiQ00056
MaxQBiQ00056
PaxDbiQ00056
PeptideAtlasiQ00056
PRIDEiQ00056
ProteomicsDBi57839

Protocols and materials databases

DNASUi3201
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360046; ENSP00000353151; ENSG00000197576
ENST00000428284; ENSP00000408845; ENSG00000197576
ENST00000610970; ENSP00000479166; ENSG00000197576
GeneIDi3201
KEGGihsa:3201
UCSCiuc003sym.4 human

Organism-specific databases

CTDi3201
DisGeNETi3201
EuPathDBiHostDB:ENSG00000197576.13
GeneCardsiHOXA4
HGNCiHGNC:5105 HOXA4
HPAiHPA060088
MIMi142953 gene
neXtProtiNX_Q00056
OpenTargetsiENSG00000197576
PharmGKBiPA29382
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiQ00056
KOiK09304
OMAiYYAPRTA
OrthoDBiEOG091G09XD
PhylomeDBiQ00056
TreeFamiTF352857

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

Miscellaneous databases

GeneWikiiHOXA4
GenomeRNAii3201
PROiPR:Q00056
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197576 Expressed in 75 organ(s), highest expression level in lower esophagus
CleanExiHS_HOXA4
ExpressionAtlasiQ00056 baseline and differential
GenevisibleiQ00056 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXA4_HUMAN
AccessioniPrimary (citable) accession number: Q00056
Secondary accession number(s): A4D180, O43366
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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Main funding by: National Institutes of Health

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