UniProtKB - Q00006 (2ABB_RABIT)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
PPP2R2B
Functioni
GO - Molecular functioni
- protein phosphatase regulator activity Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAlternative name(s): PP2A subunit B isoform B55-beta PP2A subunit B isoform PR55-beta PP2A subunit B isoform R2-beta PP2A subunit B isoform beta |
Gene namesi | Name:PPP2R2B |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Membrane By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- membrane Source: UniProtKB-SubCell
- protein phosphatase type 2A complex Source: InterPro
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071426 | ‹1 – 413 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAdd BLAST | ›413 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 245 | PhosphoserineBy similarity | 1 | |
Modified residuei | 265 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 268 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinExpressioni
Tissue specificityi
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity).
Interacts with TOMM22 (By similarity).
Interacts with IER5 (via N- and C-terminal regions) (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9986.ENSOCUP00000022978 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | ‹1 – 31 | WD 1Add BLAST | ›31 | |
Repeati | 57 – 98 | WD 2Add BLAST | 42 | |
Repeati | 141 – 179 | WD 3Add BLAST | 39 | |
Repeati | 190 – 230 | WD 4Add BLAST | 41 | |
Repeati | 249 – 287 | WD 5Add BLAST | 39 | |
Repeati | 304 – 345 | WD 6Add BLAST | 42 | |
Repeati | 380 – 412 | WD 7Add BLAST | 33 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1354, Eukaryota |
InParanoidi | Q00006 |
OMAi | RRKNQSH |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit PS00678, WD_REPEATS_1, 1 hit |
i Sequence
Sequence statusi: Fragment.
10 20 30 40 50
EFNHTGELLA TGDKGGRVVI FQREQESKNQ VHRRGEYNVY STFQSHEPEF
60 70 80 90 100
DYLKSLEIEE KINKIRWLPQ QNAAYFLLST NDKTVKLWKV SERDKRPEGY
110 120 130 140 150
NLKDEEGRLR DPATITTLRV PVLRPMDLMV EATPRRVFAN AHTYHINSIS
160 170 180 190 200
VNSDYETYMS ADDLRINLWN FEITNQSFNI VDIKPANMEE LTEVITAAEF
210 220 230 240 250
HPHHCNTFVY SSSKGTIRLC DMRASALCDR HTKFFEEPED PSNRSFFSEI
260 270 280 290 300
ISSISDVKFS HSGRYIMTRD YLTVKVWDLN MENRPIETYQ VHDYLRSKLC
310 320 330 340 350
SLYENDCIFD KFECVWNGSD SVIMTGSYNN FFRMFDRNTK RDVTLEASRE
360 370 380 390 400
NSKPRAILKP RKVCVGGKRR KDEISVDSLD FSKKILHTAW HPSENIIAVA
410
ATNNLYIFQD KVN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64931 mRNA Translation: AAA31458.1 |
PIRi | C38351 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64931 mRNA Translation: AAA31458.1 |
PIRi | C38351 |
3D structure databases
SMRi | Q00006 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000022978 |
Phylogenomic databases
eggNOGi | KOG1354, Eukaryota |
InParanoidi | Q00006 |
OMAi | RRKNQSH |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit PS00678, WD_REPEATS_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2ABB_RABIT | |
Accessioni | Q00006Primary (citable) accession number: Q00006 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families