UniProtKB - Q00005 (2ABB_HUMAN)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
PPP2R2B
Functioni
GO - Molecular functioni
- protein phosphatase regulator activity Source: GO_Central
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- peptidyl-serine dephosphorylation Source: GO_Central
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q00005 |
SignaLinki | Q00005 |
SIGNORi | Q00005 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAlternative name(s): PP2A subunit B isoform B55-beta PP2A subunit B isoform PR55-beta PP2A subunit B isoform R2-beta PP2A subunit B isoform beta |
Gene namesi | Name:PPP2R2B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9305, PPP2R2B |
MIMi | 604325, gene |
neXtProti | NX_Q00005 |
VEuPathDBi | HostDB:ENSG00000156475.18 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
Mitochondrion
- Mitochondrion By similarity
- Mitochondrion outer membrane By similarity
Other locations
- Cytoplasm By similarity
Note: Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity).By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: GO_Central
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB
- mitochondrion Source: UniProtKB
Other locations
- protein phosphatase type 2A complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Involvement in diseasei
Spinocerebellar ataxia 12 (SCA12)1 Publication
Keywords - Diseasei
Disease variant, Neurodegeneration, Spinocerebellar ataxiaOrganism-specific databases
DisGeNETi | 5521 |
GeneReviewsi | PPP2R2B |
MalaCardsi | PPP2R2B |
MIMi | 604326, phenotype |
OpenTargetsi | ENSG00000156475 |
Orphaneti | 98762, Spinocerebellar ataxia type 12 |
PharmGKBi | PA33669 |
Miscellaneous databases
Pharosi | Q00005, Tbio |
Genetic variation databases
BioMutai | PPP2R2B |
DMDMi | 231446 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071421 | 1 – 443 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAdd BLAST | 443 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 275 | PhosphoserineBy similarity | 1 | |
Modified residuei | 295 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 298 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q00005 |
MassIVEi | Q00005 |
MaxQBi | Q00005 |
PaxDbi | Q00005 |
PeptideAtlasi | Q00005 |
PRIDEi | Q00005 |
ProteomicsDBi | 32258 57832 57833 [Q00005-2] 57834 [Q00005-3] 57835 [Q00005-4] 57836 [Q00005-5] |
PTM databases
iPTMneti | Q00005 |
PhosphoSitePlusi | Q00005 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000156475, Expressed in corpus callosum and 208 other tissues |
ExpressionAtlasi | Q00005, baseline and differential |
Genevisiblei | Q00005, HS |
Organism-specific databases
HPAi | ENSG00000156475, Tissue enriched (brain) |
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity).
Interacts with TOMM22 (By similarity).
Interacts with IER5 (via N- and C-terminal regions) (PubMed:25816751, PubMed:26496226).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ00005
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-1052159,EBI-77613 |
PDPK1 [O15530] | 8 | EBI-1052159,EBI-717097 |
PPP2R1A [P30153] | 10 | EBI-1052159,EBI-302388 |
RPS6KB1 [P23443] | 2 | EBI-1052159,EBI-1775921 |
Protein-protein interaction databases
BioGRIDi | 111513, 64 interactors |
IntActi | Q00005, 181 interactors |
STRINGi | 9606.ENSP00000377936 |
Miscellaneous databases
RNActi | Q00005, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 22 – 61 | WD 1Add BLAST | 40 | |
Repeati | 87 – 128 | WD 2Add BLAST | 42 | |
Repeati | 171 – 209 | WD 3Add BLAST | 39 | |
Repeati | 220 – 260 | WD 4Add BLAST | 41 | |
Repeati | 279 – 317 | WD 5Add BLAST | 39 | |
Repeati | 334 – 375 | WD 6Add BLAST | 42 | |
Repeati | 410 – 442 | WD 7Add BLAST | 33 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
HOGENOMi | CLU_021713_3_3_1 |
InParanoidi | Q00005 |
OMAi | RRKNQSH |
OrthoDBi | 810409at2759 |
PhylomeDBi | Q00005 |
TreeFami | TF105553 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit PS00678, WD_REPEATS_1, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEDIDTRKI NNSFLRDHSY ATEADIISTV EFNHTGELLA TGDKGGRVVI
60 70 80 90 100
FQREQESKNQ VHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ
110 120 130 140 150
QNAAYFLLST NDKTVKLWKV SERDKRPEGY NLKDEEGRLR DPATITTLRV
160 170 180 190 200
PVLRPMDLMV EATPRRVFAN AHTYHINSIS VNSDYETYMS ADDLRINLWN
210 220 230 240 250
FEITNQSFNI VDIKPANMEE LTEVITAAEF HPHHCNTFVY SSSKGTIRLC
260 270 280 290 300
DMRASALCDR HTKFFEEPED PSNRSFFSEI ISSISDVKFS HSGRYIMTRD
310 320 330 340 350
YLTVKVWDLN MENRPIETYQ VHDYLRSKLC SLYENDCIFD KFECVWNGSD
360 370 380 390 400
SVIMTGSYNN FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCVGGKRR
410 420 430 440
KDEISVDSLD FSKKILHTAW HPSENIIAVA ATNNLYIFQD KVN
The sequence of this isoform differs from the canonical sequence as follows:
1-21: MEEDIDTRKINNSFLRDHSYA → MKCFSRYLPYIFRPPNTILSSSCH
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RGF9 | D6RGF9_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2B | 58 | Annotation score: | ||
H0YA16 | H0YA16_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2B | 78 | Annotation score: | ||
E9PCT7 | E9PCT7_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2B | 44 | Annotation score: | ||
D6RB57 | D6RB57_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2B | 49 | Annotation score: | ||
D6RF04 | D6RF04_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2B | 37 | Annotation score: | ||
E5RFC4 | E5RFC4_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2B | 40 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | T → A in BAH11838 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 62 | H → N in BI669304 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 109 | S → F in BAH12040 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 163 | T → S in BI490027 (Ref. 6) Curated | 1 | |
Sequence conflicti | 164 | P → S in BAF82406 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 292 | S → R in BAH12040 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051738 | 36 | G → V. Corresponds to variant dbSNP:rs11547494Ensembl. | 1 | |
Natural variantiVAR_078654 | 138 | R → P Probable disease-associated variant found in a patient with moderate intellectual disability, authism and intractable epilepsy. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044923 | 1 – 23 | MEEDI…SYATE → MNYPDENTYGNK in isoform 6. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_037976 | 1 – 21 | MEEDI…DHSYA → MKCFSRYLPYIFRPPNTILS SSCH in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_037977 | 1 – 21 | MEEDI…DHSYA → MIPGIGTLTQDTLWCFSQVK GTIEIGT in isoform 3. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_037978 | 1 | M → MVLQPSERHYRDWNHRRLGP WCSPTGSPAPLSCETGCGEG SWILVCRLLVPTQVSLLSM in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_037979 | 1 | M → MLLSLPALHLQTSEHHPFFQ LPHRRLGPWCSPTGSPAPLS CETGCGEGSWILVCRLLVPT QVSLLSM in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_045748 | 1 | M → MHQPPPASCSSSSSSSSSSC ECARVGVRVSALAPAAAPCP APRQLPYPRLPEPPSRGTST LIPARLGPWCSPTGSPAPLS CETGCGEGSWILVCRLLVPT QVSLLSM in isoform 7. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64930 mRNA Translation: AAA36493.1 AK056192 mRNA Translation: BAG51642.1 Sequence problems. AK289717 mRNA Translation: BAF82406.1 AK294659 mRNA Translation: BAH11838.1 AK295347 mRNA Translation: BAH12040.1 AC008728 Genomic DNA No translation available. AC009186 Genomic DNA No translation available. AC010251 Genomic DNA No translation available. AC011386 Genomic DNA No translation available. AC011357 Genomic DNA No translation available. AC091919 Genomic DNA No translation available. AC091924 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61829.1 CH471062 Genomic DNA Translation: EAW61831.1 CH471062 Genomic DNA Translation: EAW61832.1 CH471062 Genomic DNA Translation: EAW61833.1 CH471062 Genomic DNA Translation: EAW61834.1 CH471062 Genomic DNA Translation: EAW61835.1 BC031790 mRNA Translation: AAH31790.1 Different initiation. BI490027 mRNA No translation available. BI669304 mRNA No translation available. |
CCDSi | CCDS4283.1 [Q00005-2] CCDS4284.2 [Q00005-5] CCDS43380.1 [Q00005-6] CCDS64281.1 [Q00005-4] CCDS64282.1 [Q00005-3] |
PIRi | B38351 |
RefSeqi | NP_001258828.1, NM_001271899.1 [Q00005-3] NP_001258829.1, NM_001271900.1 [Q00005-4] NP_001258877.1, NM_001271948.1 [Q00005-6] NP_858060.2, NM_181674.2 [Q00005-5] NP_858061.2, NM_181675.3 [Q00005-1] NP_858062.1, NM_181676.2 [Q00005-2] NP_858063.1, NM_181677.2 NP_858064.1, NM_181678.2 [Q00005-6] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64930 mRNA Translation: AAA36493.1 AK056192 mRNA Translation: BAG51642.1 Sequence problems. AK289717 mRNA Translation: BAF82406.1 AK294659 mRNA Translation: BAH11838.1 AK295347 mRNA Translation: BAH12040.1 AC008728 Genomic DNA No translation available. AC009186 Genomic DNA No translation available. AC010251 Genomic DNA No translation available. AC011386 Genomic DNA No translation available. AC011357 Genomic DNA No translation available. AC091919 Genomic DNA No translation available. AC091924 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61829.1 CH471062 Genomic DNA Translation: EAW61831.1 CH471062 Genomic DNA Translation: EAW61832.1 CH471062 Genomic DNA Translation: EAW61833.1 CH471062 Genomic DNA Translation: EAW61834.1 CH471062 Genomic DNA Translation: EAW61835.1 BC031790 mRNA Translation: AAH31790.1 Different initiation. BI490027 mRNA No translation available. BI669304 mRNA No translation available. |
CCDSi | CCDS4283.1 [Q00005-2] CCDS4284.2 [Q00005-5] CCDS43380.1 [Q00005-6] CCDS64281.1 [Q00005-4] CCDS64282.1 [Q00005-3] |
PIRi | B38351 |
RefSeqi | NP_001258828.1, NM_001271899.1 [Q00005-3] NP_001258829.1, NM_001271900.1 [Q00005-4] NP_001258877.1, NM_001271948.1 [Q00005-6] NP_858060.2, NM_181674.2 [Q00005-5] NP_858061.2, NM_181675.3 [Q00005-1] NP_858062.1, NM_181676.2 [Q00005-2] NP_858063.1, NM_181677.2 NP_858064.1, NM_181678.2 [Q00005-6] |
3D structure databases
SMRi | Q00005 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111513, 64 interactors |
IntActi | Q00005, 181 interactors |
STRINGi | 9606.ENSP00000377936 |
PTM databases
iPTMneti | Q00005 |
PhosphoSitePlusi | Q00005 |
Genetic variation databases
BioMutai | PPP2R2B |
DMDMi | 231446 |
Proteomic databases
jPOSTi | Q00005 |
MassIVEi | Q00005 |
MaxQBi | Q00005 |
PaxDbi | Q00005 |
PeptideAtlasi | Q00005 |
PRIDEi | Q00005 |
ProteomicsDBi | 32258 57832 57833 [Q00005-2] 57834 [Q00005-3] 57835 [Q00005-4] 57836 [Q00005-5] |
Protocols and materials databases
Antibodypediai | 27589, 215 antibodies |
DNASUi | 5521 |
Genome annotation databases
Organism-specific databases
CTDi | 5521 |
DisGeNETi | 5521 |
GeneCardsi | PPP2R2B |
GeneReviewsi | PPP2R2B |
HGNCi | HGNC:9305, PPP2R2B |
HPAi | ENSG00000156475, Tissue enriched (brain) |
MalaCardsi | PPP2R2B |
MIMi | 604325, gene 604326, phenotype |
neXtProti | NX_Q00005 |
OpenTargetsi | ENSG00000156475 |
Orphaneti | 98762, Spinocerebellar ataxia type 12 |
PharmGKBi | PA33669 |
VEuPathDBi | HostDB:ENSG00000156475.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
HOGENOMi | CLU_021713_3_3_1 |
InParanoidi | Q00005 |
OMAi | RRKNQSH |
OrthoDBi | 810409at2759 |
PhylomeDBi | Q00005 |
TreeFami | TF105553 |
Enzyme and pathway databases
PathwayCommonsi | Q00005 |
SignaLinki | Q00005 |
SIGNORi | Q00005 |
Miscellaneous databases
BioGRID-ORCSi | 5521, 7 hits in 875 CRISPR screens |
ChiTaRSi | PPP2R2B, human |
GeneWikii | PPP2R2B |
GenomeRNAii | 5521 |
Pharosi | Q00005, Tbio |
PROi | PR:Q00005 |
RNActi | Q00005, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156475, Expressed in corpus callosum and 208 other tissues |
ExpressionAtlasi | Q00005, baseline and differential |
Genevisiblei | Q00005, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit PS00678, WD_REPEATS_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2ABB_HUMAN | |
Accessioni | Q00005Primary (citable) accession number: Q00005 Secondary accession number(s): A6NEJ2 G3V149 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 10, 2021 | |
This is version 203 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants