UniProtKB - P9WQM1 (CYSA_MYCTU)
Protein
Sulfate/thiosulfate import ATP-binding protein CysA
Gene
cysA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
Catalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 37 – 44 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled sulfate transmembrane transporter activity Source: UniProtKB-UniRule
- ATPase-coupled thiosulfate transmembrane transporter activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- sulfate assimilation Source: Reactome
- sulfate transport Source: MTBBASE
Keywordsi
Molecular function | Translocase |
Biological process | Sulfate transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MTU-936635, Sulfate assimilation |
Names & Taxonomyi
Protein namesi | Recommended name: Sulfate/thiosulfate import ATP-binding protein CysAUniRule annotation (EC:7.3.2.3UniRule annotation)Alternative name(s): Sulfate-transporting ATPaseUniRule annotation |
Gene namesi | Name:cysAUniRule annotation Ordered Locus Names:Rv2397c ORF Names:MTCY253.24 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2397c |
Subcellular locationi
- Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation
GO - Cellular componenti
- ATP-binding cassette (ABC) transporter complex Source: InterPro
- plasma membrane Source: Reactome
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000092276 | 2 – 351 | Sulfate/thiosulfate import ATP-binding protein CysAAdd BLAST | 350 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | P9WQM1 |
PTM databases
iPTMneti | P9WQM1 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).
UniRule annotationProtein-protein interaction databases
STRINGi | 83332.Rv2397c |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 235 | ABC transporterUniRule annotationAdd BLAST | 231 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family. [View classification]UniRule annotation
Phylogenomic databases
eggNOGi | COG1118, Bacteria |
PhylomeDBi | P9WQM1 |
Family and domain databases
CDDi | cd03296, ABC_CysA_sulfate_importer, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR014769, ABC_CysA_ATP-bd_C IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR008995, Mo/tungstate-bd_C_term_dom IPR027417, P-loop_NTPase IPR005666, Sulph_transpt1 IPR024765, TOBE-like |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF12857, TOBE_3, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50331, SSF50331, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00968, 3a0106s01, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51237, CYSA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P9WQM1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTYAIVVADA TKRYGDFVAL DHVDFVVPTG SLTALLGPSG SGKSTLLRTI
60 70 80 90 100
AGLDQPDTGT ITINGRDVTR VPPQRRGIGF VFQHYAAFKH LTVRDNVAFG
110 120 130 140 150
LKIRKRPKAE IKAKVDNLLQ VVGLSGFQSR YPNQLSGGQR QRMALARALA
160 170 180 190 200
VDPEVLLLDE PFGALDAKVR EELRAWLRRL HDEVHVTTVL VTHDQAEALD
210 220 230 240 250
VADRIAVLHK GRIEQVGSPT DVYDAPANAF VMSFLGAVST LNGSLVRPHD
260 270 280 290 300
IRVGRTPNMA VAAADGTAGS TGVLRAVVDR VVVLGFEVRV ELTSAATGGA
310 320 330 340 350
FTAQITRGDA EALALREGDT VYVRATRVPP IAGGVSGVDD AGVERVKVTS
T
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45187.1 |
PIRi | H70682 |
RefSeqi | WP_003412325.1, NZ_NVQJ01000054.1 YP_177879.1, NC_000962.3 |
Genome annotation databases
EnsemblBacteriai | CCP45187; CCP45187; Rv2397c |
GeneIDi | 45426385 885663 |
KEGGi | mtu:Rv2397c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45187.1 |
PIRi | H70682 |
RefSeqi | WP_003412325.1, NZ_NVQJ01000054.1 YP_177879.1, NC_000962.3 |
3D structure databases
SMRi | P9WQM1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2397c |
PTM databases
iPTMneti | P9WQM1 |
Proteomic databases
PaxDbi | P9WQM1 |
Genome annotation databases
EnsemblBacteriai | CCP45187; CCP45187; Rv2397c |
GeneIDi | 45426385 885663 |
KEGGi | mtu:Rv2397c |
Organism-specific databases
TubercuListi | Rv2397c |
Phylogenomic databases
eggNOGi | COG1118, Bacteria |
PhylomeDBi | P9WQM1 |
Enzyme and pathway databases
Reactomei | R-MTU-936635, Sulfate assimilation |
Family and domain databases
CDDi | cd03296, ABC_CysA_sulfate_importer, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR014769, ABC_CysA_ATP-bd_C IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR008995, Mo/tungstate-bd_C_term_dom IPR027417, P-loop_NTPase IPR005666, Sulph_transpt1 IPR024765, TOBE-like |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF12857, TOBE_3, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50331, SSF50331, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00968, 3a0106s01, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51237, CYSA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CYSA_MYCTU | |
Accessioni | P9WQM1Primary (citable) accession number: P9WQM1 Secondary accession number(s): L0TC79, P0A4W2, P71747 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | November 26, 2014 | |
Last modified: | February 10, 2021 | |
This is version 44 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families