UniProtKB - P9WQI9 (BACA_MYCTU)
Protein
Vitamin B12 transport ATP-binding protein BacA
Gene
bacA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
ABC transporter involved in uptake of vitamin B12 and related corrinoids. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Contributes to maintenance of chronic infections.2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 460 – 467 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- response to host immune response Source: MTBBASE
Keywordsi
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6014-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Vitamin B12 transport ATP-binding protein BacA |
Gene namesi | Name:bacA Ordered Locus Names:Rv1819c ORF Names:MTCY1A11.24c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1819c |
Subcellular locationi
- Cell membrane Curated; Multi-pass membrane protein PROSITE-ProRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 40 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 68 – 88 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 121 – 141 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 213 – 233 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 249 – 269 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 332 – 352 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- extracellular region Source: MTBBASE
- integral component of plasma membrane Source: MTBBASE
- plasma membrane Source: MTBBASE
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Disruption results in bleomycin resistance and alters the outcome of a chronic infection within the host, but does not alter sensitivity to other membrane-disrupting agents and resistance to clinically important antituberculosis drugs. Deletion eliminates the ability of the bacterium to transport vitamin B12 and related corrinoids.2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093265 | 1 – 639 | Vitamin B12 transport ATP-binding protein BacAAdd BLAST | 639 |
Proteomic databases
PaxDbi | P9WQI9 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 83332.Rv1819c |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 67 – 393 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 327 | |
Domaini | 427 – 639 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 213 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105CQ0 Bacteria COG4178 LUCA |
KOi | K02471 |
OMAi | QLRYEAD |
PhylomeDBi | P9WQI9 |
Family and domain databases
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase |
Pfami | View protein in Pfam PF06472 ABC_membrane_2, 1 hit PF00005 ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WQI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPKLFKPSI DWSRAFPDSV YWVGKAWTIS AICVLAILVL LRYLTPWGRQ
60 70 80 90 100
FWRITRAYFV GPNSVRVWLM LGVLLLSVVL AVRLNVLFSY QGNDMYTALQ
110 120 130 140 150
KAFEGIASGD GTVKRSGVRG FWMSIGVFSV MAVLHVTRVM ADIYLTQRFI
160 170 180 190 200
IAWRVWLTHH LTQDWLDGRA YYRDLFIDET IDNPDQRIQQ DVDIFTAGAG
210 220 230 240 250
GTPNAPSNGT ASTLLFGAVQ SIISVISFTA ILWNLSGTLN IFGVSIPRAM
260 270 280 290 300
FWTVLVYVFV ATVISFIIGR PLIWLSFRNE KLNAAFRYAL VRLRDAAEAV
310 320 330 340 350
GFYRGERVEG TQLQRRFTPV IDNYRRYVRR SIAFNGWNLS VSQTIVPLPW
360 370 380 390 400
VIQAPRLFAG QIDFGDVGQT ATSFGNIHDS LSFFRNNYDA FASFRAAIIR
410 420 430 440 450
LHGLVDANEK GRALPAVLTR PSDDESVELN DIEVRTPAGD RLIDPLDVRL
460 470 480 490 500
DRGGSLVITG RSGAGKTTLL RSLAELWPYA SGTLHRPGGE NETMFLSQLP
510 520 530 540 550
YVPLGTLRDV VCYPNSAAAI PDATLRDTLT KVALAPLCDR LDEERDWAKV
560 570 580 590 600
LSPGEQQRVA FARILLTKPK AVFLDESTSA LDTGLEFALY QLLRSELPDC
610 620 630
IVISVSHRPA LERLHENQLE LLGGGQWRLA PVEAAPAEV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44585.1 |
PIRi | D70720 |
RefSeqi | NP_216335.1, NC_000962.3 WP_003900416.1, NZ_NVQJ01000013.1 |
Genome annotation databases
EnsemblBacteriai | CCP44585; CCP44585; Rv1819c |
GeneIDi | 885539 |
KEGGi | mtu:Rv1819c mtv:RVBD_1819c |
PATRICi | fig|83332.111.peg.2024 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44585.1 |
PIRi | D70720 |
RefSeqi | NP_216335.1, NC_000962.3 WP_003900416.1, NZ_NVQJ01000013.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 83332.Rv1819c |
Proteomic databases
PaxDbi | P9WQI9 |
Genome annotation databases
EnsemblBacteriai | CCP44585; CCP44585; Rv1819c |
GeneIDi | 885539 |
KEGGi | mtu:Rv1819c mtv:RVBD_1819c |
PATRICi | fig|83332.111.peg.2024 |
Organism-specific databases
TubercuListi | Rv1819c |
Phylogenomic databases
eggNOGi | ENOG4105CQ0 Bacteria COG4178 LUCA |
KOi | K02471 |
OMAi | QLRYEAD |
PhylomeDBi | P9WQI9 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6014-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase |
Pfami | View protein in Pfam PF06472 ABC_membrane_2, 1 hit PF00005 ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BACA_MYCTU | |
Accessioni | P9WQI9Primary (citable) accession number: P9WQI9 Secondary accession number(s): L0TAH3, Q50614 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names