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Protein

Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD3

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Miscellaneous

Was identified as a high-confidence drug target.

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

GO - Molecular functioni

GO - Biological processi

  • mycolic acid biosynthetic process Source: MTBBASE

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (EC:6.4.1.2)
Short name:
ACCase beta chain
Gene namesi
Name:accD3
Ordered Locus Names:Rv0904c
ORF Names:MTCY31.32c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0904c

Subcellular locationi

GO - Cellular componenti

  • acetyl-CoA carboxylase complex Source: InterPro
  • plasma membrane Source: MTBBASE

Pathology & Biotechi

Disruption phenotypei

Not essential for growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001997731 – 495Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST495

Proteomic databases

PaxDbiP9WQH9

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0904c

Structurei

3D structure databases

ProteinModelPortaliP9WQH9
SMRiP9WQH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 236CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST236
Domaini242 – 470CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 470CarboxyltransferasePROSITE-ProRule annotationAdd BLAST470

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated

Phylogenomic databases

eggNOGiENOG4105D8K Bacteria
COG0777 LUCA
COG0825 LUCA
KOiK01962
K01963
OMAiAVIACEF
PhylomeDBiP9WQH9

Family and domain databases

InterProiView protein in InterPro
IPR034733 AcCoA_carboxyl
IPR000438 Acetyl_CoA_COase_Trfase_b_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
IPR011762 COA_CT_N
PfamiView protein in Pfam
PF01039 Carboxyl_trans, 1 hit
PRINTSiPR01070 ACCCTRFRASEB
SUPFAMiSSF52096 SSF52096, 2 hits
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit
PS50980 COA_CT_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P9WQH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRITTDQLR HAVLDRGSFV SWDSEPLAVP VADSYARELA AARAATGADE
60 70 80 90 100
SVQTGEGRVF GRRVAVVACE FDFLGGSIGV AAAERITAAV ERATAERLPL
110 120 130 140 150
LASPSSGGTR MQEGTVAFLQ MVKIAAAIQL HNQARLPYLV YLRHPTTGGV
160 170 180 190 200
FASWGSLGHL TVAEPGALIG FLGPRVYELL YGDPFPSGVQ TAENLRRHGI
210 220 230 240 250
IDGVVALDRL RPMLDRALTV LIDAPEPLPA PQTPAPVPDV PTWDSVVASR
260 270 280 290 300
RPDRPGVRQL LRHGATDRVL LSGTDQGEAA TTLLALARFG GQPTVVLGQQ
310 320 330 340 350
RAVGGGGSTV GPAALREARR GMALAAELCL PLVLVIDAAG PALSAAAEQG
360 370 380 390 400
GLAGQIAHCL AELVTLDTPT VSILLGQGSG GPALAMLPAD RVLAALHGWL
410 420 430 440 450
APLPPEGASA IVFRDTAHAA ELAAAQGIRS ADLLKSGIVD TIVPEYPDAA
460 470 480 490
DEPIEFALRL SNAIAAEVHA LRKIPAPERL ATRLQRYRRI GLPRD
Length:495
Mass (Da):51,772
Last modified:April 16, 2014 - v1
Checksum:i156C96E927FF950C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43652.1
PIRiE70783
RefSeqiNP_215419.1, NC_000962.3
WP_003404691.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP43652; CCP43652; Rv0904c
GeneIDi885279
KEGGimtu:Rv0904c

Similar proteinsi

Entry informationi

Entry nameiACCD_MYCTU
AccessioniPrimary (citable) accession number: P9WQH9
Secondary accession number(s): L0T824, P63405, Q10561
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: February 28, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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