UniProtKB - P9WQH7 (PCC5_MYCTU)
Protein
Probable propionyl-CoA carboxylase beta chain 5
Gene
accD5
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalytic activityi
- EC:6.4.1.3
: propanoyl-CoA degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Probable propionyl-CoA carboxylase beta chain 5 (accD5), Probable propionyl-CoA carboxylase beta chain 6 (accD6)
- no protein annotated in this organism
- Probable methylmalonyl-CoA mutase large subunit (mutB), Probable methylmalonyl-CoA mutase small subunit (mutA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.
GO - Molecular functioni
- acetyl-CoA carboxylase activity Source: MTBBASE
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- propionyl-CoA carboxylase activity Source: MTBBASE
GO - Biological processi
- carbon fixation Source: MTBBASE
Keywordsi
Molecular function | Ligase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:G185E-7554-MONOMER |
UniPathwayi | UPA00945;UER00908 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable propionyl-CoA carboxylase beta chain 5 (EC:6.4.1.3)Short name: PCCase Alternative name(s): Propanoyl-CoA:carbon dioxide ligase |
Gene namesi | Name:accD5 Synonyms:pccB Ordered Locus Names:Rv3280 ORF Names:MTCY71.20 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3280 |
Subcellular locationi
GO - Cellular componenti
- acetyl-CoA carboxylase complex Source: MTBBASE
- cell wall Source: MTBBASE
- plasma membrane Source: MTBBASE
- protein-containing complex Source: MTBBASE
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000199799 | 1 – 548 | Probable propionyl-CoA carboxylase beta chain 5Add BLAST | 548 |
Proteomic databases
PaxDbi | P9WQH7 |
Interactioni
Subunit structurei
Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.
By similarityBinary interactionsi
P9WQH7
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-7151762,EBI-7151762 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
MINTi | P9WQH7 |
STRINGi | 83332.Rv3280 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WQH7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 281 | CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST | 257 | |
Domaini | 295 – 541 | CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST | 247 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 541 | CarboxyltransferasePROSITE-ProRule annotationAdd BLAST | 517 |
Sequence similaritiesi
Belongs to the AccD/PCCB family.Curated
Phylogenomic databases
eggNOGi | COG4799, Bacteria |
OMAi | CHFSVMA |
PhylomeDBi | P9WQH7 |
Family and domain databases
InterProi | View protein in InterPro IPR034733, AcCoA_carboxyl IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C IPR011762, COA_CT_N |
Pfami | View protein in Pfam PF01039, Carboxyl_trans, 1 hit |
SUPFAMi | SSF52096, SSF52096, 2 hits |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit PS50980, COA_CT_NTER, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WQH7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSVTDRSAH SAERSTEHTI DIHTTAGKLA ELHKRREESL HPVGEDAVEK
60 70 80 90 100
VHAKGKLTAR ERIYALLDED SFVELDALAK HRSTNFNLGE KRPLGDGVVT
110 120 130 140 150
GYGTIDGRDV CIFSQDATVF GGSLGEVYGE KIVKVQELAI KTGRPLIGIN
160 170 180 190 200
DGAGARIQEG VVSLGLYSRI FRNNILASGV IPQISLIMGA AAGGHVYSPA
210 220 230 240 250
LTDFVIMVDQ TSQMFITGPD VIKTVTGEEV TMEELGGAHT HMAKSGTAHY
260 270 280 290 300
AASGEQDAFD YVRELLSYLP PNNSTDAPRY QAAAPTGPIE ENLTDEDLEL
310 320 330 340 350
DTLIPDSPNQ PYDMHEVITR LLDDEFLEIQ AGYAQNIVVG FGRIDGRPVG
360 370 380 390 400
IVANQPTHFA GCLDINASEK AARFVRTCDC FNIPIVMLVD VPGFLPGTDQ
410 420 430 440 450
EYNGIIRRGA KLLYAYGEAT VPKITVITRK AYGGAYCVMG SKDMGCDVNL
460 470 480 490 500
AWPTAQIAVM GASGAVGFVY RQQLAEAAAN GEDIDKLRLR LQQEYEDTLV
510 520 530 540
NPYVAAERGY VDAVIPPSHT RGYIGTALRL LERKIAQLPP KKHGNVPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46099.1 |
PIRi | A70980 |
RefSeqi | NP_217797.1, NC_000962.3 WP_003417136.1, NZ_NVQJ01000003.1 |
Genome annotation databases
EnsemblBacteriai | CCP46099; CCP46099; Rv3280 |
GeneIDi | 23490451 888725 |
KEGGi | mtu:Rv3280 mtv:RVBD_3280 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46099.1 |
PIRi | A70980 |
RefSeqi | NP_217797.1, NC_000962.3 WP_003417136.1, NZ_NVQJ01000003.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2A7S | X-ray | 2.90 | A/B/C/D/E/F | 1-548 | [»] | |
2BZR | X-ray | 2.20 | A/B/C/D/E/F | 1-548 | [»] | |
SMRi | P9WQH7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
MINTi | P9WQH7 |
STRINGi | 83332.Rv3280 |
Proteomic databases
PaxDbi | P9WQH7 |
Genome annotation databases
EnsemblBacteriai | CCP46099; CCP46099; Rv3280 |
GeneIDi | 23490451 888725 |
KEGGi | mtu:Rv3280 mtv:RVBD_3280 |
Organism-specific databases
TubercuListi | Rv3280 |
Phylogenomic databases
eggNOGi | COG4799, Bacteria |
OMAi | CHFSVMA |
PhylomeDBi | P9WQH7 |
Enzyme and pathway databases
UniPathwayi | UPA00945;UER00908 |
BioCyci | MetaCyc:G185E-7554-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR034733, AcCoA_carboxyl IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C IPR011762, COA_CT_N |
Pfami | View protein in Pfam PF01039, Carboxyl_trans, 1 hit |
SUPFAMi | SSF52096, SSF52096, 2 hits |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit PS50980, COA_CT_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCC5_MYCTU | |
Accessioni | P9WQH7Primary (citable) accession number: P9WQH7 Secondary accession number(s): L0TF57, P96885 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families