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Protein

Alcohol dehydrogenase B

Gene

adhB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc 1; catalyticBy similarity1
Metal bindingi62Zinc 1; catalyticBy similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi169Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase B (EC:1.1.1.1)
Gene namesi
Name:adhB
Ordered Locus Names:Rv0761c
ORF Names:MTCY369.06c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0761c

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607431 – 375Alcohol dehydrogenase BAdd BLAST375

Proteomic databases

PaxDbiP9WQC7

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0761c

Structurei

3D structure databases

ProteinModelPortaliP9WQC7
SMRiP9WQC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG41088XM Bacteria
COG1062 LUCA
KOiK00121
OMAiKRITDGG
PhylomeDBiP9WQC7

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR023921 ADH_Zn_actinomycetes
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03989 Rxyl_3153, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P9WQC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTKGALIWE FNQPWSVEEI EIGDPRKDEV KIQMEAAGMC RSDHHLVTGD
60 70 80 90 100
IPMAGFPVLG GHEGAGIVTE VGPGVDDFAP GDHVVLAFIP SCGKCPSCQA
110 120 130 140 150
GMRNLCDLGA GLLAGESVTD GSFRIQARGQ NVYPMTLLGT FSPYMVVHRS
160 170 180 190 200
SVVKIDPSVP FEVACLVGCG VTTGYGSAVR TADVRPGDDV AIVGLGGVGM
210 220 230 240 250
AALQGAVSAG ARYVFAVEPV EWKRDQALKF GATHVYPDIN AALMGIAEVT
260 270 280 290 300
YGLMAQKVII TVGKLDGADV DSYLTITAKG GTCVLTAIGS LVDTQVTLNL
310 320 330 340 350
AMLTLLQKNI QGTIFGGGNP HYDIPKLLSM YKAGKLNLDD MVTTAYKLEQ
360 370
INDGYQDMLN GKNIRGVIRY TDDDR
Length:375
Mass (Da):39,748
Last modified:April 16, 2014 - v1
Checksum:i8DBF5D1504EECDE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43508.1
PIRiD70706
RefSeqiWP_003403885.1, NZ_NVQJ01000035.1
YP_177754.1, NC_000962.3

Genome annotation databases

EnsemblBacteriaiCCP43508; CCP43508; Rv0761c
GeneIDi888738
KEGGimtu:Rv0761c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43508.1
PIRiD70706
RefSeqiWP_003403885.1, NZ_NVQJ01000035.1
YP_177754.1, NC_000962.3

3D structure databases

ProteinModelPortaliP9WQC7
SMRiP9WQC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0761c

Proteomic databases

PaxDbiP9WQC7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43508; CCP43508; Rv0761c
GeneIDi888738
KEGGimtu:Rv0761c

Organism-specific databases

TubercuListiRv0761c

Phylogenomic databases

eggNOGiENOG41088XM Bacteria
COG1062 LUCA
KOiK00121
OMAiKRITDGG
PhylomeDBiP9WQC7

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR023921 ADH_Zn_actinomycetes
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03989 Rxyl_3153, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADHB_MYCTU
AccessioniPrimary (citable) accession number: P9WQC7
Secondary accession number(s): L0T7F0, P71818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 7, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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Main funding by: National Institutes of Health

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