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Protein

Probable alcohol dehydrogenase adh

Gene

adh

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Was identified as a high-confidence drug target.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43Zinc 1; catalyticBy similarity1
Metal bindingi64Zinc 1; catalyticBy similarity1
Metal bindingi97Zinc 2By similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi111Zinc 2By similarity1
Metal bindingi163Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alcohol dehydrogenase adh (EC:1.1.1.1)
Gene namesi
Name:adh
Ordered Locus Names:Rv1530
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003913401 – 367Probable alcohol dehydrogenase adhAdd BLAST367

Proteomic databases

PaxDbiP9WQC3

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1530

Structurei

3D structure databases

ProteinModelPortaliP9WQC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1063 LUCA
KOiK00001
OMAiGLNMIRK
PhylomeDBiP9WQC3

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P9WQC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDGAVVRAL VLEAPRRLVV RQYRLPRIGD DDALVRVEAC GLCGTDHEQY
60 70 80 90 100
TGELAGGFAF VPGHETVGTI AAIGPRAEQR WGVSAGDRVA VEVFQSCRQC
110 120 130 140 150
ANCRGGEYRR CVRHGLADMY GFIPVDREPG LWGGYAEYQY LAPDSMVLRV
160 170 180 190 200
AGDLSPEVAT LFNPLGAGIR WGVTIPETKP GDVVAVLGPG IRGLCAAAAA
210 220 230 240 250
KGAGAGFVMV TGLGPRDADR LALAAQFGAD LAVDVAIDDP VAALTEQTGG
260 270 280 290 300
LADVVVDVTA KAPAAFAQAI ALARPAGTVV VAGTRGVGSG APGFSPDVVV
310 320 330 340 350
FKELRVLGAL GVDATAYRAA LDLLVSGRYP FASLPRRCVR LEGAEDLLAT
360
MAGERDGVPP IHGVLTP
Length:367
Mass (Da):37,997
Last modified:April 16, 2014 - v1
Checksum:iCE6FC6E7C33EFA2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44294.1
PIRiC70820
RefSeqiNP_216046.1, NC_000962.3
WP_003407690.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP44294; CCP44294; Rv1530
GeneIDi886426
KEGGimtu:Rv1530

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44294.1
PIRiC70820
RefSeqiNP_216046.1, NC_000962.3
WP_003407690.1, NZ_KK339370.1

3D structure databases

ProteinModelPortaliP9WQC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1530

Proteomic databases

PaxDbiP9WQC3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44294; CCP44294; Rv1530
GeneIDi886426
KEGGimtu:Rv1530

Organism-specific databases

TubercuListiRv1530

Phylogenomic databases

eggNOGiCOG1063 LUCA
KOiK00001
OMAiGLNMIRK
PhylomeDBiP9WQC3

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH_MYCTU
AccessioniPrimary (citable) accession number: P9WQC3
Secondary accession number(s): L0T9P8, O53904, Q7D8B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 18, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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