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Protein

Probable alcohol dehydrogenase AdhA

Gene

adhA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Was identified as a high-confidence drug target.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Zinc 1; catalyticBy similarity1
Metal bindingi73Zinc 1; catalyticBy similarity1
Metal bindingi109Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi123Zinc 2By similarity1
Metal bindingi165Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alcohol dehydrogenase AdhA (EC:1.1.1.1)
Gene namesi
Name:adhA
Ordered Locus Names:Rv1862
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1862

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003913412 – 346Probable alcohol dehydrogenase AdhAAdd BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP9WQC1

PTM databases

iPTMnetiP9WQC1

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1862

Structurei

3D structure databases

ProteinModelPortaliP9WQC1
SMRiP9WQC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DQ4 Bacteria
COG1064 LUCA
KOiK13953
OMAiGAENLCP
PhylomeDBiP9WQC1

Family and domain databases

CDDicd08298 CAD2, 1 hit
InterProiView protein in InterPro
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR014187 ADH_Zn_typ-2
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02822 adh_fam_2, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P9WQC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSPATTATM SAWQVRRPGP MDTGPLERVT TRVPRPAPSE LLVAVHACGV
60 70 80 90 100
CRTDLHVTEG DLPVHRERVI PGHEVVGEVI EVGSAVGAAA GGEFDRGDRV
110 120 130 140 150
GIAWLRHTCG VCKYCRRGSE NLCPQSRYTG WDADGGYAEF TTVPAAFAHH
160 170 180 190 200
LPSGYSDSEL APLLCAGIIG YRSLLRTELP PGGRLGLYGF GGSAHITAQV
210 220 230 240 250
ALAQGAEIHV MTRGARARKL ALQLGAASAQ DAADRPPVPL DAAILFAPVG
260 270 280 290 300
DLVLPALEAL DRGGILAIAG IHLTDIPDLN YQQHLFQERQ IRSVTSNTRA
310 320 330 340
DARAFFDFAA QHHIEVTTPE YPLGQADRAL GDLSAGRIAG AAVLLI
Length:346
Mass (Da):36,632
Last modified:April 16, 2014 - v1
Checksum:i107AD0EF4256812C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44628.1
PIRiF70666
RefSeqiNP_216378.1, NC_000962.3
WP_003409345.1, NZ_NVQJ01000013.1

Genome annotation databases

EnsemblBacteriaiCCP44628; CCP44628; Rv1862
GeneIDi885652
KEGGimtu:Rv1862

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44628.1
PIRiF70666
RefSeqiNP_216378.1, NC_000962.3
WP_003409345.1, NZ_NVQJ01000013.1

3D structure databases

ProteinModelPortaliP9WQC1
SMRiP9WQC1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1862

PTM databases

iPTMnetiP9WQC1

Proteomic databases

PaxDbiP9WQC1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44628; CCP44628; Rv1862
GeneIDi885652
KEGGimtu:Rv1862

Organism-specific databases

TubercuListiRv1862

Phylogenomic databases

eggNOGiENOG4105DQ4 Bacteria
COG1064 LUCA
KOiK13953
OMAiGAENLCP
PhylomeDBiP9WQC1

Family and domain databases

CDDicd08298 CAD2, 1 hit
InterProiView protein in InterPro
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR014187 ADH_Zn_typ-2
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02822 adh_fam_2, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADHA_MYCTU
AccessioniPrimary (citable) accession number: P9WQC1
Secondary accession number(s): L0T838, P95153, Q7D7W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 7, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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