UniProtKB - P9WQ45 (FAD25_MYCTU)
Protein
Putative fatty-acid--CoA ligase fadD25
Gene
fadD25
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
GO - Molecular functioni
- adenylyltransferase activity Source: GO_Central
- ligase activity Source: UniProtKB-KW
GO - Biological processi
- fatty acid biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5709-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Putative fatty-acid--CoA ligase fadD25 (EC:6.2.1.-)Alternative name(s): Acyl-CoA synthetase |
Gene namesi | Name:fadD25 Ordered Locus Names:Rv1521 ORF Names:MTCY19G5.07 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1521 |
Subcellular locationi
- Cell membrane Curated; Multi-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 109 – 129 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 229 – 249 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: MTBBASE
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193137 | 1 – 583 | Putative fatty-acid--CoA ligase fadD25Add BLAST | 583 |
Proteomic databases
PaxDbi | P9WQ45 |
PRIDEi | P9WQ45 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4107RCI Bacteria COG0318 LUCA |
OMAi | QIMTAYY |
PhylomeDBi | P9WQ45 |
Family and domain databases
CDDi | cd05931 FAAL, 1 hit |
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR000873 AMP-dep_Synth/Lig IPR042099 AMP-dep_Synthh-like_sf IPR040097 FAAL |
Pfami | View protein in Pfam PF00501 AMP-binding, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WQ45-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVVESSLPG VLRERASFQP NDKALTFIDY ERSWDGVEET LTWSQLYRRT
60 70 80 90 100
LNLAAQLREH GSTGDRALIL APQSLDYVVS FIASLQAGIV AVPLSIPQGG
110 120 130 140 150
AHDERTVSVF ADTAPAIVLT ASSVVDNVVE YVQPQPGQNA PAVIEVDRLD
160 170 180 190 200
LDARPSSGSR SAAHGHPDIL YLQYTSGSTR TPAGVMVSNK NLFANFEQIM
210 220 230 240 250
TSYYGVYGKV APPGSTVVSW LPFYHDMGFV LGLILPILAG IPAVLTSPIG
260 270 280 290 300
FLQRPARWIQ MLASNTLAFT AAPNFAFDLA SRKTKDEDME GLDLGGVHGI
310 320 330 340 350
LNGSERVQPV TLKRFIDRFA PFNLDPKAIR PSYGMAEATV YVATRKAGQP
360 370 380 390 400
PKIVQFDPQK LPDGQAERTE SDGGTPLVSY GIVDTQLVRI VDPDTGIERP
410 420 430 440 450
AGTIGEIWVH GDNVAIGYWQ KPEATERTFS ATIVNPSEGT PAGPWLRTGD
460 470 480 490 500
SGFLSEGELF IMGRIKDLLI VYGRNHSPDD IEATIQTISP GRCAAIAVSE
510 520 530 540 550
HGAEKLVAII ELKKKDESDD EAAERLGFVK REVTSAISKS HGLSVADLVL
560 570 580
VSPGSIPITT SGKIRRAQCV ELYRQDEFTR LDA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44285.1 |
PIRi | A70723 |
RefSeqi | NP_216037.1, NC_000962.3 WP_003901187.1, NZ_NVQJ01000004.1 |
Genome annotation databases
EnsemblBacteriai | CCP44285; CCP44285; Rv1521 |
GeneIDi | 886448 |
KEGGi | mtu:Rv1521 mtv:RVBD_1521 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44285.1 |
PIRi | A70723 |
RefSeqi | NP_216037.1, NC_000962.3 WP_003901187.1, NZ_NVQJ01000004.1 |
3D structure databases
SMRi | P9WQ45 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1521 |
Proteomic databases
PaxDbi | P9WQ45 |
PRIDEi | P9WQ45 |
Genome annotation databases
EnsemblBacteriai | CCP44285; CCP44285; Rv1521 |
GeneIDi | 886448 |
KEGGi | mtu:Rv1521 mtv:RVBD_1521 |
Organism-specific databases
TubercuListi | Rv1521 |
Phylogenomic databases
eggNOGi | ENOG4107RCI Bacteria COG0318 LUCA |
OMAi | QIMTAYY |
PhylomeDBi | P9WQ45 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5709-MONOMER |
Family and domain databases
CDDi | cd05931 FAAL, 1 hit |
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR000873 AMP-dep_Synth/Lig IPR042099 AMP-dep_Synthh-like_sf IPR040097 FAAL |
Pfami | View protein in Pfam PF00501 AMP-binding, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FAD25_MYCTU | |
Accessioni | P9WQ45Primary (citable) accession number: P9WQ45 Secondary accession number(s): L0T8I2, Q50586 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 29 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names