UniProtKB - P9WPX4 (ASPG_MYCTO)
Protein
Probable L-asparaginase
Gene
ansA
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Catalytic activityi
- EC:3.5.1.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 12 | O-isoaspartyl threonine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- asparaginase activity Source: UniProtKB-EC
GO - Biological processi
- asparagine metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Names & Taxonomyi
Protein namesi | Recommended name: Probable L-asparaginase (EC:3.5.1.1)Short name: L-ASNase Alternative name(s): L-asparagine amidohydrolase |
Gene namesi | Name:ansA Ordered Locus Names:MT1590 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000426876 | 1 – 315 | Probable L-asparaginaseAdd BLAST | 315 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 315 | Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST | 314 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 51 – 53 | Substrate bindingBy similarity | 3 | |
Regioni | 84 – 85 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the asparaginase 1 family.Curated
Phylogenomic databases
HOGENOMi | CLU_019134_1_0_11 |
Family and domain databases
CDDi | cd08964, L-asparaginase_II, 1 hit |
Gene3Di | 3.40.50.1170, 1 hit 3.40.50.40, 1 hit |
InterProi | View protein in InterPro IPR004550, AsnASE_II IPR036152, Asp/glu_Ase-like_sf IPR006034, Asparaginase/glutaminase-like IPR020827, Asparaginase/glutaminase_AS1 IPR027475, Asparaginase/glutaminase_AS2 IPR040919, Asparaginase_C IPR027473, L-asparaginase_C IPR027474, L-asparaginase_N IPR037152, L-asparaginase_N_sf |
Pfami | View protein in Pfam PF00710, Asparaginase, 1 hit PF17763, Asparaginase_C, 1 hit |
PIRSFi | PIRSF001220, L-ASNase_gatD, 1 hit |
PRINTSi | PR00139, ASNGLNASE |
SMARTi | View protein in SMART SM00870, Asparaginase, 1 hit |
SUPFAMi | SSF53774, SSF53774, 1 hit |
PROSITEi | View protein in PROSITE PS00144, ASN_GLN_ASE_1, 1 hit PS00917, ASN_GLN_ASE_2, 1 hit PS51732, ASN_GLN_ASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WPX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARLTVITTG GTISTTAGPD GVLRPTHCGA TLIAGLDMDS DIEVVDLMAL
60 70 80 90 100
DSSKLTPADW DRIGAAVQEA FRGGADGVVI THGTDTLEET ALWLDLTYAG
110 120 130 140 150
SRPVVLTGAM LSADAPGADG PANLRDALAV AADPAARDLG VLVSFGGRVL
160 170 180 190 200
QPLGLHKVAN PDLCGFAGES LGFTSGGVRL TRTKTRPYLG DLGAAVAPRV
210 220 230 240 250
DIVAVYPGSD AVAMDACVAA GARAVVLEAL GSGNAGAAVI EGVRRHCRDG
260 270 280 290 300
SDPVVIAVST RVAGARVGAG YGPGHDLVEA GAVMVPRLPP SQARVLLMAA
310
LAANSPVADV IDRWG
Sequence cautioni
The sequence AAK45856 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK45856.1 Different initiation. |
PIRi | G70760 |
Genome annotation databases
EnsemblBacteriai | AAK45856; AAK45856; MT1590 |
KEGGi | mtc:MT1590 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK45856.1 Different initiation. |
PIRi | G70760 |
3D structure databases
SMRi | P9WPX4 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK45856; AAK45856; MT1590 |
KEGGi | mtc:MT1590 |
Phylogenomic databases
HOGENOMi | CLU_019134_1_0_11 |
Family and domain databases
CDDi | cd08964, L-asparaginase_II, 1 hit |
Gene3Di | 3.40.50.1170, 1 hit 3.40.50.40, 1 hit |
InterProi | View protein in InterPro IPR004550, AsnASE_II IPR036152, Asp/glu_Ase-like_sf IPR006034, Asparaginase/glutaminase-like IPR020827, Asparaginase/glutaminase_AS1 IPR027475, Asparaginase/glutaminase_AS2 IPR040919, Asparaginase_C IPR027473, L-asparaginase_C IPR027474, L-asparaginase_N IPR037152, L-asparaginase_N_sf |
Pfami | View protein in Pfam PF00710, Asparaginase, 1 hit PF17763, Asparaginase_C, 1 hit |
PIRSFi | PIRSF001220, L-ASNase_gatD, 1 hit |
PRINTSi | PR00139, ASNGLNASE |
SMARTi | View protein in SMART SM00870, Asparaginase, 1 hit |
SUPFAMi | SSF53774, SSF53774, 1 hit |
PROSITEi | View protein in PROSITE PS00144, ASN_GLN_ASE_1, 1 hit PS00917, ASN_GLN_ASE_2, 1 hit PS51732, ASN_GLN_ASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ASPG_MYCTO | |
Accessioni | P9WPX4Primary (citable) accession number: P9WPX4 Secondary accession number(s): L0T751, P63627, Q10759 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 29 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |