UniProtKB - P9WPT1 (CTPE_MYCTU)
Protein
Calcium-transporting ATPase CtpE
Gene
ctpE
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
P-type ATPase involved in specific uptake of calcium.By similarity
Catalytic activityi
- EC:7.2.2.10By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 301 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 301 | MagnesiumBy similarity | 1 | |
Metal bindingi | 303 | Magnesium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 536 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium transmembrane transporter activity, phosphorylative mechanism Source: GO_Central
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Translocase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5062-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ctpE Ordered Locus Names:Rv0908 ORF Names:MTCY21C12.02 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0908 |
Subcellular locationi
- Cell membrane Curated; Multi-pass membrane protein Sequence analysis
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 215 – 235 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 254 – 274 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 601 – 621 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 633 – 653 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 667 – 687 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 703 – 723 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 729 – 749 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 764 – 784 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046341 | 1 – 797 | Calcium-transporting ATPase CtpEAdd BLAST | 797 |
Proteomic databases
PaxDbi | P9WPT1 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105C52 Bacteria COG0474 LUCA |
KOi | K12952 |
OMAi | HFVRRVM |
PhylomeDBi | P9WPT1 |
Family and domain databases
Gene3Di | 3.40.1110.10, 2 hits 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR001757 P_typ_ATPase |
PRINTSi | PR00120 HATPASE |
SUPFAMi | SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81665 SSF81665, 1 hit |
TIGRFAMsi | TIGR01494 ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WPT1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRSASATAG LTDAEVAQRV AEGKSNDIPE RVTRTVGQIV RANVFTRINA
60 70 80 90 100
ILGVLLLIVL ATGSLINGMF GLLIIANSVI GMVQEIRAKQ TLDKLAIIGQ
110 120 130 140 150
AKPLVRRQSG TRTRSTNEVV LDDIIELGPG DQVVVDGEVV EEENLEIDES
160 170 180 190 200
LLTGEADPIA KDAGDTVMSG SFVVSGAGAY RATKVGSEAY AAKLAAEASK
210 220 230 240 250
FTLVKSELRN GINRILQFIT YLLVPAGLLT IYTQLFTTHV GWRESVLRMV
260 270 280 290 300
GALVPMVPEG LVLMTSIAFA VGVVRLGQRQ CLVQELPAIE GLARVDVVCA
310 320 330 340 350
DKTGTLTESG MRVCEVEELD GAGRQESVAD VLAALAAADA RPNASMQAIA
360 370 380 390 400
EAFHSPPGWV VAANAPFKSA TKWSGVSFRD HGNWVIGAPD VLLDPASVAA
410 420 430 440 450
RQAERIGAQG LRVLLLAAGS VAVDHAQAPG QVTPVALVVL EQKVRPDARE
460 470 480 490 500
TLDYFAVQNV SVKVISGDNA VSVGAVADRL GLHGEAMDAR ALPTGREELA
510 520 530 540 550
DTLDSYTSFG RVRPDQKRAI VHALQSHGHT VAMTGDGVND VLALKDADIG
560 570 580 590 600
VAMGSGSPAS RAVAQIVLLN NRFATLPHVV GEGRRVIGNI ERVANLFLTK
610 620 630 640 650
TVYSVLLALL VGIECLIAIP LRRDPLLFPF QPIHVTIAAW FTIGIPAFIL
660 670 680 690 700
SLAPNNERAY PGFVRRVMTS AVPFGLVIGV ATFVTYLAAY QGRYASWQEQ
710 720 730 740 750
EQASTAALIT LLMTALWVLA VIARPYQWWR LALVLASGLA YVVIFSLPLA
760 770 780 790
REKFLLDASN LATTSIALAV GVVGAATIEA MWWIRSRMLG VKPRVWR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43656.1 |
PIRi | D70581 |
RefSeqi | NP_215423.1, NC_000962.3 WP_003898639.1, NZ_NVQJ01000001.1 |
Genome annotation databases
EnsemblBacteriai | CCP43656; CCP43656; Rv0908 |
GeneIDi | 885657 |
KEGGi | mtu:Rv0908 mtv:RVBD_0908 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43656.1 |
PIRi | D70581 |
RefSeqi | NP_215423.1, NC_000962.3 WP_003898639.1, NZ_NVQJ01000001.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 83332.Rv0908 |
Proteomic databases
PaxDbi | P9WPT1 |
Genome annotation databases
EnsemblBacteriai | CCP43656; CCP43656; Rv0908 |
GeneIDi | 885657 |
KEGGi | mtu:Rv0908 mtv:RVBD_0908 |
Organism-specific databases
TubercuListi | Rv0908 |
Phylogenomic databases
eggNOGi | ENOG4105C52 Bacteria COG0474 LUCA |
KOi | K12952 |
OMAi | HFVRRVM |
PhylomeDBi | P9WPT1 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5062-MONOMER |
Family and domain databases
Gene3Di | 3.40.1110.10, 2 hits 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR001757 P_typ_ATPase |
PRINTSi | PR00120 HATPASE |
SUPFAMi | SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81665 SSF81665, 1 hit |
TIGRFAMsi | TIGR01494 ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTPE_MYCTU | |
Accessioni | P9WPT1Primary (citable) accession number: P9WPT1 Secondary accession number(s): L0T595, O08365, P0A504 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names