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UniProtKB - P9WPS5 (CTPI_MYCTU)

Entry version 40 (13 Nov 2019)
Sequence version 1 (16 Apr 2014)
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Protein

Probable cation-transporting ATPase I

Gene

ctpI

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei10534-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1340MagnesiumBy similarity1
Metal bindingi1344MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MTBH37RV:G185E-4224-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable cation-transporting ATPase I (EC:7.2.2.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ctpI
Ordered Locus Names:Rv0107c
ORF Names:MTCY251.26c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...TubercuListi		Rv0107c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Transmembranei673 – 693HelicalSequence analysisAdd BLAST21
Transmembranei778 – 798HelicalSequence analysisAdd BLAST21
Transmembranei968 – 988HelicalSequence analysisAdd BLAST21
Transmembranei997 – 1017HelicalSequence analysisAdd BLAST21
Transmembranei1401 – 1421HelicalSequence analysisAdd BLAST21
Transmembranei1432 – 1452HelicalSequence analysisAdd BLAST21
Transmembranei1547 – 1567HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463471 – 1632Probable cation-transporting ATPase IAdd BLAST1632

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P9WPS5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		83332.Rv0107c

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105C52 Bacteria
COG0474 LUCA

KEGG Orthology (KO)

More...KOi		K12955

Database for complete collections of gene phylogenies

More...PhylomeDBi		P9WPS5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR001757 P_typ_ATPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00689 Cation_ATPase_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00120 HATPASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01494 ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WPS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIPGVATVL GGVTNGVAQT VRAGARLPGS AAAAVQTLAS PVLELTGPVV 
        60         70         80         90        100
QSVVQTTGRA IGVRGSHNES PDGMTPPVRW RSGRRVHFDL DPLLPFPRWH 
       110        120        130        140        150
EHAAMVEEPV RRIPGVAEAH VEGSLGRLVV ELEPDADSDI AVDEVRDVVS 
       160        170        180        190        200
AVAADIFLAG SVSSPNSAPF ADPGNPLAIL VPLTAAAMDL VAMGATVTGW 
       210        220        230        240        250
VARLPAAPQT TRALAALINH QPRMVSLMES RLGRVGTDIA LAATTAAANG 
       260        270        280        290        300
LTQSLGTPLL DLVQRSLQIS EAAAHRRVWR DREPALASPR RPQAPVVPII 
       310        320        330        340        350
SSAGAKSQEP RHSWAAAAAG EASHVVVGGS IDAAIDTAKG SRAGPVEQYV 
       360        370        380        390        400
NQAANGSLIA AASALVAGGG TEDAAGAILA GVPRAAHMGR QAFAAVLGRG 
       410        420        430        440        450
LANTGQLVLD PGALRRLDRV RVVVIDGAAL RGDNRAVLHA QGDEPGWDDD 
       460        470        480        490        500
RVYEVADALL HGEQAPEPDP DELPATGARL RWAPAQGPSA TPAQGLEHAD 
       510        520        530        540        550
LVVDGQCVGS VDVGWEVDPY AIPLLQTAHR TGARVVLRHV AGTEDLSASV 
       560        570        580        590        600
GSTHPPGTPL LKLVRELRAD RGPVLLITAV HRDFASTDTL AALAIADVGV 
       610        620        630        640        650
ALDDPRGATP WTADLITGTD LAAAVRILSA LPVARAASES AVHLAQGGTT 
       660        670        680        690        700
LAGLLLVTGE QDKTTNPASF RRWLNPVNAA AATALVSGMW SAAKVLRMPD 
       710        720        730        740        750
PTPQPLTAWH ALDPEIVYSR LAGGSRPLAV EPGIPAWRRI LDDLSYEPVM 
       760        770        780        790        800
APLRGPARTL AQLAVATRHE LADPLTPILA VGAAASAIVG SNIDALLVAG 
       810        820        830        840        850
VMTVNAITGG VQRLRAEAAA AELFAEQDQL VRRVVVPAVA TTRRRLEAAR 
       860        870        880        890        900
HATRTATVSA KSLRVGDVID LAAPEVVPAD ARLLVAEDLE VDESFLTGES 
       910        920        930        940        950
LPVDKQVDPV AVNDPDRASM LFEGSTIVAG HARAIVVATG VGTAAHRAIS 
       960        970        980        990       1000
AVADVETAAG VQARLRELTS KVLPMTLAGG AAVTALALLR RASLRQAVAD 
      1010       1020       1030       1040       1050
GVAIAVAAVP EGLPLVATLS QLAAAQRLTA RGALVRSPRT IEALGRVDTI 
      1060       1070       1080       1090       1100
CFDKTGTLTE NRLRVVCALP SSTAAERDPL PQTTDAPSAE VLRAAARAST 
      1110       1120       1130       1140       1150
QPHNGEGHAH ATDEAILAAA SALAGSLSSQ GDSEWVVLAE VPFESSRGYA 
      1160       1170       1180       1190       1200
AAIGRVGTDG IPMLMLKGAP ETILPRCRLA DPGVDHEHAE SVVRHLAEQG 
      1210       1220       1230       1240       1250
LRVLAVAQRT WDNGTTHDDE TDADAVDAVA HDLELIGYVG LADTARSSSR 
      1260       1270       1280       1290       1300
PLIEALLDAE RNVVLITGDH PITARAIARQ LGLPADARVV TGAELAVLDE 
      1310       1320       1330       1340       1350
EAHAKLAADM QVFARVSPEQ KVQIVAALQR CGRVTAMVGD GANDAAAIRM 
      1360       1370       1380       1390       1400
ADVGIGVSGR GSSAARGAAD IVLTDDDLGV LLDALVEGRS MWAGVRDAVT 
      1410       1420       1430       1440       1450
ILVGGNVGEV LFTVIGTAFG AGRAPVGTRQ LLLVNLLTDM FPALAVAVTS 
      1460       1470       1480       1490       1500
QFAEPDDAEY PTDDAAERAQ REHRRAVLIG PTPSLDAPLL RQIVNRGVVT 
      1510       1520       1530       1540       1550
AAGATAAWAI GRWTPGTERR TATMGLTALV MTQLAQTLLT RRHSPLVIAT 
      1560       1570       1580       1590       1600
ALGSAGVLVG IIQTPVISHF SGVPRWDRSP GRASSAPRQE PPQSQRWHRS 
      1610       1620       1630 
GWQAQSVSCN LMNALTTRKT LTRVDRTYRR PR
Length:1,632
Mass (Da):169,607
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA29F651A55EF7FD8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP42832.1

Protein sequence database of the Protein Information Resource

More...PIRi		C70752

NCBI Reference Sequences

More...RefSeqi		NP_214621.1, NC_000962.3
WP_010886065.1, NZ_NVQJ01000053.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CCP42832; CCP42832; Rv0107c

Database of genes from NCBI RefSeq genomes

More...GeneIDi		886915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mtu:Rv0107c
mtv:RVBD_0107c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP42832.1
PIRiC70752
RefSeqiNP_214621.1, NC_000962.3
WP_010886065.1, NZ_NVQJ01000053.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi83332.Rv0107c

Proteomic databases

PaxDbiP9WPS5

Genome annotation databases

EnsemblBacteriaiCCP42832; CCP42832; Rv0107c
GeneIDi886915
KEGGimtu:Rv0107c
mtv:RVBD_0107c

Organism-specific databases

TubercuListiRv0107c

Phylogenomic databases

eggNOGiENOG4105C52 Bacteria
COG0474 LUCA
KOiK12955
PhylomeDBiP9WPS5

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4224-MONOMER

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PRINTSiPR00120 HATPASE
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTPI_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WPS5
Secondary accession number(s): L0T5J4, Q10900
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 13, 2019
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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