UniProtKB - P9WPG5 (CRLS_MYCTU)
Protein
Putative cardiolipin synthase
Gene
pgsA2
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
May catalyze the biosynthesis of cardiolipin from phosphatidylglycerol (PG) and CDP-diacylglycerol. May also catalyze the synthesis of phosphatidylinositol.1 Publication
Catalytic activityi
- 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol = a cardiolipin + CMP + H+1 PublicationEC:2.7.8.411 Publication
- 1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
: phospholipid metabolism Pathwayi
This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.
GO - Molecular functioni
GO - Biological processi
- glycerophospholipid biosynthetic process Source: GO_Central
- phospholipid biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
Chemistry databases
SwissLipidsi | SLP:000001157 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pgsA21 PublicationImported Ordered Locus Names:Rv1822 ORF Names:MTCY1A11.21c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1822 |
Subcellular locationi
- Cell membrane Curated; Multi-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 27 – 47 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056779 | 1 – 209 | Putative cardiolipin synthaseAdd BLAST | 209 |
Proteomic databases
PaxDbi | P9WPG5 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0558, Bacteria |
OMAi | GTTLYWW |
PhylomeDBi | P9WPG5 |
Family and domain databases
Gene3Di | 1.20.120.1760, 1 hit |
InterProi | View protein in InterPro IPR000462, CDP-OH_P_trans IPR043130, CDP-OH_PTrfase_TM_dom IPR004570, Phosphatidylglycerol_P_synth |
Pfami | View protein in Pfam PF01066, CDP-OH_P_transf, 1 hit |
PIRSFi | PIRSF000847, Phos_ph_gly_syn, 1 hit |
PROSITEi | View protein in PROSITE PS00379, CDP_ALCOHOL_P_TRANSF, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WPG5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPVLTQNRV LTVPNMLSVI RLALIPAFVY VVLSAHANGW GVAILVFSGV
60 70 80 90 100
SDWADGKIAR LLNQSSRLGA LLDPAVDRLY MVTVPIVFGL SGIVPWWFVL
110 120 130 140 150
TLLTRDALLA GTLPLLWSRG LSALPVTYVG KAATFGFMVG FPTILLGQCD
160 170 180 190 200
PLWSHVLLAC GWAFLIWGMY AYLWAFVLYA VQMTMVVRQM PKLKGRAHRP
AAQNAGERG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44588.1 |
PIRi | G70720 |
RefSeqi | NP_216338.1, NC_000962.3 WP_003409227.1, NZ_NVQJ01000013.1 |
Genome annotation databases
EnsemblBacteriai | CCP44588; CCP44588; Rv1822 |
GeneIDi | 23492007 885126 |
KEGGi | mtu:Rv1822 mtv:RVBD_1822 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44588.1 |
PIRi | G70720 |
RefSeqi | NP_216338.1, NC_000962.3 WP_003409227.1, NZ_NVQJ01000013.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 83332.Rv1822 |
Chemistry databases
SwissLipidsi | SLP:000001157 |
Proteomic databases
PaxDbi | P9WPG5 |
Genome annotation databases
EnsemblBacteriai | CCP44588; CCP44588; Rv1822 |
GeneIDi | 23492007 885126 |
KEGGi | mtu:Rv1822 mtv:RVBD_1822 |
Organism-specific databases
TubercuListi | Rv1822 |
Phylogenomic databases
eggNOGi | COG0558, Bacteria |
OMAi | GTTLYWW |
PhylomeDBi | P9WPG5 |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
Family and domain databases
Gene3Di | 1.20.120.1760, 1 hit |
InterProi | View protein in InterPro IPR000462, CDP-OH_P_trans IPR043130, CDP-OH_PTrfase_TM_dom IPR004570, Phosphatidylglycerol_P_synth |
Pfami | View protein in Pfam PF01066, CDP-OH_P_transf, 1 hit |
PIRSFi | PIRSF000847, Phos_ph_gly_syn, 1 hit |
PROSITEi | View protein in PROSITE PS00379, CDP_ALCOHOL_P_TRANSF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRLS_MYCTU | |
Accessioni | P9WPG5Primary (citable) accession number: P9WPG5 Secondary accession number(s): L0T801, P63753, Q50611 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families