UniProtKB - P9WPF7 (CDSA_MYCTU)
Protein
Phosphatidate cytidylyltransferase
Gene
cdsA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalytic activityi
- EC:2.7.7.41
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glycerol-3-phosphate acyltransferase (plsB)
- no protein annotated in this organism
- Phosphatidate cytidylyltransferase (cdsA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- phosphatidate cytidylyltransferase activity Source: GO_Central
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7133-MONOMER |
UniPathwayi | UPA00557;UER00614 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidate cytidylyltransferase (EC:2.7.7.41)Alternative name(s): CDP-DAG synthase CDP-DG synthase CDP-diacylglycerol synthase Short name: CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase |
Gene namesi | Name:cdsA Ordered Locus Names:Rv2881c ORF Names:MTCY274.12c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2881c |
Subcellular locationi
- Cell membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 58 – 78 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 124 – 144 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 173 – 193 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 263 – 283 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- cell wall Source: MTBBASE
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
ChainiPRO_0000090743 | 1 – 328 | Phosphatidate cytidylyltransferaseAdd BLAST | 328 | ||
Isoform 2 (identifier: P9WPF7-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: P9WPF7-2) | |||||
Modified residuei | 2 | N-acetylthreonineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | P9WPF7 |
PRIDEi | P9WPF7 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105KNE Bacteria COG0575 LUCA |
KOi | K00981 |
OMAi | FGKHPMA |
PhylomeDBi | P9WPF7 |
Family and domain databases
InterProi | View protein in InterPro IPR000374 PC_trans |
PROSITEi | View protein in PROSITE PS01315 CDS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketIsoform 1 (identifier: P9WPF7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSWLNTKKAS CWRSSGRSAT KSVTTNDAGT GNPAEQPARG AKQQPATETS
60 70 80 90 100
RAGRDLRAAI VVGLSIGLVL IAVLVFVPRV WVAIVAVATL VATHEVVRRL
110 120 130 140 150
REAGYLIPVI PLLIGGQAAV WLTWPFGAVG ALAGFGGMVV VCMIWRLFMQ
160 170 180 190 200
DSVTRPTTGG APSPGNYLSD VSATVFLAVW VPLFCSFGAM LVYPENGSGW
210 220 230 240 250
VFCMMIAVIA SDVGGYAVGV LFGKHPMVPT ISPKKSWEGF AGSLVCGITA
260 270 280 290 300
TIITATFLVG KTPWIGALLG VLFVLTTALG DLVESQVKRD LGIKDMGRLL
310 320
PGHGGLMDRL DGILPSAVAA WIVLTLLP
Sequence cautioni
The sequence CCP45683 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059173 | 1 – 22 | Missing in isoform 2. Add BLAST | 22 | |
Alternative sequenceiVSP_059174 | 23 | V → M in isoform 2. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45683.1 Different initiation. |
PIRi | D70924 |
RefSeqi | NP_217397.1, NC_000962.3 [P9WPF7-2] |
Genome annotation databases
EnsemblBacteriai | CCP45683; CCP45683; Rv2881c |
GeneIDi | 888910 |
KEGGi | mtu:Rv2881c |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45683.1 Different initiation. |
PIRi | D70924 |
RefSeqi | NP_217397.1, NC_000962.3 [P9WPF7-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 83332.Rv2881c |
Proteomic databases
PaxDbi | P9WPF7 |
PRIDEi | P9WPF7 |
Genome annotation databases
EnsemblBacteriai | CCP45683; CCP45683; Rv2881c |
GeneIDi | 888910 |
KEGGi | mtu:Rv2881c |
Organism-specific databases
TubercuListi | Rv2881c |
Phylogenomic databases
eggNOGi | ENOG4105KNE Bacteria COG0575 LUCA |
KOi | K00981 |
OMAi | FGKHPMA |
PhylomeDBi | P9WPF7 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
BioCyci | MTBH37RV:G185E-7133-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR000374 PC_trans |
PROSITEi | View protein in PROSITE PS01315 CDS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDSA_MYCTU | |
Accessioni | P9WPF7Primary (citable) accession number: P9WPF7 Secondary accession number(s): L0TDN0, P63758, Q10807 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | November 2, 2016 | |
Last modified: | October 16, 2019 | |
This is version 37 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways