UniProtKB - P9WPD3 (CISY2_MYCTU)
Protein
Putative citrate synthase 2
Gene
citA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Miscellaneous
Citrate synthase is found in nearly all cells capable of oxidative metabolism.By similarity
Catalytic activityi
- EC:2.3.3.16PROSITE-ProRule annotation
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- 2-methylcitrate synthase (prpC), Citrate synthase 1 (gltA2), 2-methylcitrate dehydratase (prpD), Putative citrate synthase 2 (citA)
- Aconitate hydratase A (acn)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 250 | PROSITE-ProRule annotation | 1 | |
Active sitei | 303 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- citrate (Si)-synthase activity Source: GO_Central
GO - Biological processi
- carbohydrate metabolic process Source: GO_Central
- tricarboxylic acid cycle Source: GO_Central
Keywordsi
Molecular function | Allosteric enzyme, Transferase |
Biological process | Tricarboxylic acid cycle |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00717 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:citA Ordered Locus Names:Rv0889c ORF Names:MTCY31.17c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0889c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000169949 | 2 – 373 | Putative citrate synthase 2Add BLAST | 372 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | P9WPD3 |
PTM databases
iPTMneti | P9WPD3 |
Family & Domainsi
Sequence similaritiesi
Belongs to the citrate synthase family.Curated
Phylogenomic databases
eggNOGi | COG0372, Bacteria |
OMAi | YWTSAAE |
PhylomeDBi | P9WPD3 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 2 hits |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P9WPD3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVVPENFVP GLDGVVAFTT EIAEPDKDGG ALRYRGVDIE DLVSQRVTFG
60 70 80 90 100
DVWALLVDGN FGSGLPPAEP FPLPIHSGDV RVDVQAGLAM LAPIWGYAPL
110 120 130 140 150
LDIDDATARQ QLARASVMAL SYVAQSARGI YQPAVPQRII DECSTVTARF
160 170 180 190 200
MTRWQGEPDP RHIEAIDAYW VSAAEHGMNA STFTARVIAS TGADVAAALS
210 220 230 240 250
GAIGAMSGPL HGGAPARVLP MLDEVERAGD ARSVVKGILD RGEKLMGFGH
260 270 280 290 300
RVYRAEDPRA RVLRAAAERL GAPRYEVAVA VEQAALSELR ERRPDRAIET
310 320 330 340 350
NVEFWAAVVL DFARVPANMM PAMFTCGRTA GWCAHILEQK RLGKLVRPSA
360 370
IYVGPGPRSP ESVDGWERVL TTA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43637.1 |
PIRi | F70781 |
RefSeqi | NP_215404.1, NC_000962.3 WP_003898633.1, NZ_NVQJ01000001.1 |
Genome annotation databases
EnsemblBacteriai | CCP43637; CCP43637; Rv0889c |
GeneIDi | 885466 |
KEGGi | mtu:Rv0889c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43637.1 |
PIRi | F70781 |
RefSeqi | NP_215404.1, NC_000962.3 WP_003898633.1, NZ_NVQJ01000001.1 |
3D structure databases
SMRi | P9WPD3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv0889c |
PTM databases
iPTMneti | P9WPD3 |
Proteomic databases
PaxDbi | P9WPD3 |
Genome annotation databases
EnsemblBacteriai | CCP43637; CCP43637; Rv0889c |
GeneIDi | 885466 |
KEGGi | mtu:Rv0889c |
Organism-specific databases
TubercuListi | Rv0889c |
Phylogenomic databases
eggNOGi | COG0372, Bacteria |
OMAi | YWTSAAE |
PhylomeDBi | P9WPD3 |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00717 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 2 hits |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CISY2_MYCTU | |
Accessioni | P9WPD3Primary (citable) accession number: P9WPD3 Secondary accession number(s): L0T808, P63777, Q10529 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 10, 2021 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families