ATP-dependent Clp protease ATP-binding subunit ClpC1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase activity Source: MTBBASE <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function."
    Kar N.P., Sikriwal D., Rath P., Choudhary R.K., Batra J.K.
    FEBS J. 275:6149-6158(2008) [PubMed] [Europe PMC] [Abstract]
• ATP binding Source: UniProtKB-KW
• protein folding chaperone Source: MTBBASE <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function."
    Kar N.P., Sikriwal D., Rath P., Choudhary R.K., Batra J.K.
    FEBS J. 275:6149-6158(2008) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: MTBBASE <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association."
    Singh A., Mai D., Kumar A., Steyn A.J.
    Proc. Natl. Acad. Sci. U.S.A. 103:11346-11351(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• protein metabolic process Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

GO - Cellular componentⁱ

• cell wall Source: MTBBASEInferred from high throughput direct assayⁱ
  • "Proteomic definition of the cell wall of Mycobacterium tuberculosis."
    Wolfe L.M., Mahaffey S.B., Kruh N.A., Dobos K.M.
    J. Proteome Res. 9:5816-5826(2010) [PubMed] [Europe PMC] [Abstract]
• cytosol Source: MTBBASEInferred from high throughput direct assayⁱ
  • "Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling."
    Mawuenyega K.G., Forst C.V., Dobos K.M., Belisle J.T., Chen J., Bradbury E.M., Bradbury A.R., Chen X.
    Mol. Biol. Cell 16:396-404(2005) [PubMed] [Europe PMC] [Abstract]
• plasma membrane Source: MTBBASEInferred from high throughput direct assayⁱ
  • "Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain."
    Gu S., Chen J., Dobos K.M., Bradbury E.M., Belisle J.T., Chen X.
    Mol. Cell Proteomics 2:1284-1296(2003) [PubMed] [Europe PMC] [Abstract]
  • "Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling."
    Mawuenyega K.G., Forst C.V., Dobos K.M., Belisle J.T., Chen J., Bradbury E.M., Bradbury A.R., Chen X.
    Mol. Biol. Cell 16:396-404(2005) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein homodimerization activity Source: MTBBASEInferred from physical interactionⁱ
  • "Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association."
    Singh A., Mai D., Kumar A., Steyn A.J.
    Proc. Natl. Acad. Sci. U.S.A. 103:11346-11351(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFERFTDRAR RVVVLAQEEA RMLNHNYIGT EHILLGLIHE GEGVAAKSLE 
        60         70         80         90        100
SLGISLEGVR SQVEEIIGQG QQAPSGHIPF TPRAKKVLEL SLREALQLGH 
       110        120        130        140        150
NYIGTEHILL GLIREGEGVA AQVLVKLGAE LTRVRQQVIQ LLSGYQGKEA 
       160        170        180        190        200
AEAGTGGRGG ESGSPSTSLV LDQFGRNLTA AAMEGKLDPV IGREKEIERV 
       210        220        230        240        250
MQVLSRRTKN NPVLIGEPGV GKTAVVEGLA QAIVHGEVPE TLKDKQLYTL 
       260        270        280        290        300
DLGSLVAGSR YRGDFEERLK KVLKEINTRG DIILFIDELH TLVGAGAAEG 
       310        320        330        340        350
AIDAASILKP KLARGELQTI GATTLDEYRK YIEKDAALER RFQPVQVGEP 
       360        370        380        390        400
TVEHTIEILK GLRDRYEAHH RVSITDAAMV AAATLADRYI NDRFLPDKAI 
       410        420        430        440        450
DLIDEAGARM RIRRMTAPPD LREFDEKIAE ARREKESAID AQDFEKAASL 
       460        470        480        490        500
RDREKTLVAQ RAEREKQWRS GDLDVVAEVD DEQIAEVLGN WTGIPVFKLT 
       510        520        530        540        550
EAETTRLLRM EEELHKRIIG QEDAVKAVSK AIRRTRAGLK DPKRPSGSFI 
       560        570        580        590        600
FAGPSGVGKT ELSKALANFL FGDDDALIQI DMGEFHDRFT ASRLFGAPPG 
       610        620        630        640        650
YVGYEEGGQL TEKVRRKPFS VVLFDEIEKA HQEIYNSLLQ VLEDGRLTDG 
       660        670        680        690        700
QGRTVDFKNT VLIFTSNLGT SDISKPVGLG FSKGGGENDY ERMKQKVNDE 
       710        720        730        740        750
LKKHFRPEFL NRIDDIIVFH QLTREEIIRM VDLMISRVAG QLKSKDMALV 
       760        770        780        790        800
LTDAAKALLA KRGFDPVLGA RPLRRTIQRE IEDQLSEKIL FEEVGPGQVV 
       810        820        830        840 
TVDVDNWDGE GPGEDAVFTF TGTRKPPAEP DLAKAGAHSA GGPEPAAR   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
   Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references