UniProtKB - P9WPC9 (CLPC1_MYCTU)
Protein
ATP-dependent Clp protease ATP-binding subunit ClpC1
Gene
clpC1
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2.By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 216 – 223 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 553 – 560 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase activity Source: MTBBASE
- ATP binding Source: UniProtKB-KW
- protein folding chaperone Source: MTBBASE
- protein homodimerization activity Source: MTBBASE
GO - Biological processi
- protein metabolic process Source: InterPro
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7874-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-dependent Clp protease ATP-binding subunit ClpC1 |
Gene namesi | Name:clpC1 Ordered Locus Names:Rv3596c ORF Names:MTCY07H7B.26 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3596c |
Subcellular locationi
GO - Cellular componenti
- cell wall Source: MTBBASE
- cytosol Source: MTBBASE
- plasma membrane Source: MTBBASE
Pathology & Biotechi
Disruption phenotypei
Depletion experiments (using anti-sense RNA) stops degradation of anti-sigma-E factor RseA.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191236 | 1 – 848 | ATP-dependent Clp protease ATP-binding subunit ClpC1Add BLAST | 848 |
Proteomic databases
PaxDbi | P9WPC9 |
PRIDEi | P9WPC9 |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
P9WNK5 | 3 | EBI-1254029,EBI-1253936 |
GO - Molecular functioni
- protein homodimerization activity Source: MTBBASE
Protein-protein interaction databases
DIPi | DIP-61228N |
IntActi | P9WPC9, 3 interactors |
STRINGi | 83332.Rv3596c |
Chemistry databases
BindingDBi | P9WPC9 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WPC9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 144 | Clp RPROSITE-ProRule annotationAdd BLAST | 143 | |
Domaini | 425 – 460 | UVRPROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 5 – 70 | Repeat 1PROSITE-ProRule annotationAdd BLAST | 66 | |
Regioni | 80 – 144 | Repeat 2PROSITE-ProRule annotationAdd BLAST | 65 | |
Regioni | 171 – 418 | IAdd BLAST | 248 | |
Regioni | 479 – 670 | IIAdd BLAST | 192 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG4105C2Z Bacteria COG0542 LUCA |
KOi | K03696 |
OMAi | QDPKRPI |
PhylomeDBi | P9WPC9 |
Family and domain databases
Gene3Di | 1.10.1780.10, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR019489 Clp_ATPase_C IPR004176 Clp_N IPR036628 Clp_N_dom_sf IPR001270 ClpA/B IPR018368 ClpA/B_CS1 IPR041546 ClpA/ClpB_AAA_lid IPR027417 P-loop_NTPase IPR001943 UVR_dom |
Pfami | View protein in Pfam PF00004 AAA, 1 hit PF07724 AAA_2, 1 hit PF17871 AAA_lid_9, 1 hit PF02861 Clp_N, 2 hits PF10431 ClpB_D2-small, 1 hit |
PRINTSi | PR00300 CLPPROTEASEA |
SMARTi | View protein in SMART SM00382 AAA, 2 hits SM01086 ClpB_D2-small, 1 hit |
SUPFAMi | SSF52540 SSF52540, 2 hits SSF81923 SSF81923, 1 hit |
PROSITEi | View protein in PROSITE PS51903 CLP_R, 1 hit PS00870 CLPAB_1, 1 hit PS50151 UVR, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WPC9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFERFTDRAR RVVVLAQEEA RMLNHNYIGT EHILLGLIHE GEGVAAKSLE
60 70 80 90 100
SLGISLEGVR SQVEEIIGQG QQAPSGHIPF TPRAKKVLEL SLREALQLGH
110 120 130 140 150
NYIGTEHILL GLIREGEGVA AQVLVKLGAE LTRVRQQVIQ LLSGYQGKEA
160 170 180 190 200
AEAGTGGRGG ESGSPSTSLV LDQFGRNLTA AAMEGKLDPV IGREKEIERV
210 220 230 240 250
MQVLSRRTKN NPVLIGEPGV GKTAVVEGLA QAIVHGEVPE TLKDKQLYTL
260 270 280 290 300
DLGSLVAGSR YRGDFEERLK KVLKEINTRG DIILFIDELH TLVGAGAAEG
310 320 330 340 350
AIDAASILKP KLARGELQTI GATTLDEYRK YIEKDAALER RFQPVQVGEP
360 370 380 390 400
TVEHTIEILK GLRDRYEAHH RVSITDAAMV AAATLADRYI NDRFLPDKAI
410 420 430 440 450
DLIDEAGARM RIRRMTAPPD LREFDEKIAE ARREKESAID AQDFEKAASL
460 470 480 490 500
RDREKTLVAQ RAEREKQWRS GDLDVVAEVD DEQIAEVLGN WTGIPVFKLT
510 520 530 540 550
EAETTRLLRM EEELHKRIIG QEDAVKAVSK AIRRTRAGLK DPKRPSGSFI
560 570 580 590 600
FAGPSGVGKT ELSKALANFL FGDDDALIQI DMGEFHDRFT ASRLFGAPPG
610 620 630 640 650
YVGYEEGGQL TEKVRRKPFS VVLFDEIEKA HQEIYNSLLQ VLEDGRLTDG
660 670 680 690 700
QGRTVDFKNT VLIFTSNLGT SDISKPVGLG FSKGGGENDY ERMKQKVNDE
710 720 730 740 750
LKKHFRPEFL NRIDDIIVFH QLTREEIIRM VDLMISRVAG QLKSKDMALV
760 770 780 790 800
LTDAAKALLA KRGFDPVLGA RPLRRTIQRE IEDQLSEKIL FEEVGPGQVV
810 820 830 840
TVDVDNWDGE GPGEDAVFTF TGTRKPPAEP DLAKAGAHSA GGPEPAAR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46419.1 |
PIRi | E70954 |
RefSeqi | WP_003419511.1, NZ_NVQJ01000056.1 YP_177995.1, NC_000962.3 |
Genome annotation databases
EnsemblBacteriai | CCP46419; CCP46419; Rv3596c |
GeneIDi | 885104 |
KEGGi | mtu:Rv3596c mtv:RVBD_3596c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46419.1 |
PIRi | E70954 |
RefSeqi | WP_003419511.1, NZ_NVQJ01000056.1 YP_177995.1, NC_000962.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3WDB | X-ray | 1.37 | A | 1-145 | [»] | |
3WDC | X-ray | 1.18 | A | 1-145 | [»] | |
3WDD | X-ray | 1.18 | A | 3-145 | [»] | |
3WDE | X-ray | 1.44 | A | 1-145 | [»] | |
6CN8 | X-ray | 1.40 | A | 1-145 | [»] | |
SMRi | P9WPC9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-61228N |
IntActi | P9WPC9, 3 interactors |
STRINGi | 83332.Rv3596c |
Chemistry databases
BindingDBi | P9WPC9 |
Proteomic databases
PaxDbi | P9WPC9 |
PRIDEi | P9WPC9 |
Genome annotation databases
EnsemblBacteriai | CCP46419; CCP46419; Rv3596c |
GeneIDi | 885104 |
KEGGi | mtu:Rv3596c mtv:RVBD_3596c |
Organism-specific databases
TubercuListi | Rv3596c |
Phylogenomic databases
eggNOGi | ENOG4105C2Z Bacteria COG0542 LUCA |
KOi | K03696 |
OMAi | QDPKRPI |
PhylomeDBi | P9WPC9 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7874-MONOMER |
Family and domain databases
Gene3Di | 1.10.1780.10, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR019489 Clp_ATPase_C IPR004176 Clp_N IPR036628 Clp_N_dom_sf IPR001270 ClpA/B IPR018368 ClpA/B_CS1 IPR041546 ClpA/ClpB_AAA_lid IPR027417 P-loop_NTPase IPR001943 UVR_dom |
Pfami | View protein in Pfam PF00004 AAA, 1 hit PF07724 AAA_2, 1 hit PF17871 AAA_lid_9, 1 hit PF02861 Clp_N, 2 hits PF10431 ClpB_D2-small, 1 hit |
PRINTSi | PR00300 CLPPROTEASEA |
SMARTi | View protein in SMART SM00382 AAA, 2 hits SM01086 ClpB_D2-small, 1 hit |
SUPFAMi | SSF52540 SSF52540, 2 hits SSF81923 SSF81923, 1 hit |
PROSITEi | View protein in PROSITE PS51903 CLP_R, 1 hit PS00870 CLPAB_1, 1 hit PS50151 UVR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLPC1_MYCTU | |
Accessioni | P9WPC9Primary (citable) accession number: P9WPC9 Secondary accession number(s): L0TD96, O06286, P0A522 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references