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UniProtKB - P9WPC9 (CLPC1_MYCTU)

Entry version 46 (02 Jun 2021)
Sequence version 1 (16 Apr 2014)
Previous versions | rss
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Protein

ATP-dependent Clp protease ATP-binding subunit ClpC1

Gene

clpC1

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity).

Degrades anti-sigma-E factor RseA in the presence of ClpP2.

By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi216 – 223ATPSequence analysis8
Nucleotide bindingi553 – 560ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.21.92, 3445

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clpC1
Ordered Locus Names:Rv3596c
ORF Names:MTCY07H7B.26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...TubercuListi		Rv3596c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Depletion experiments (using anti-sense RNA) stops degradation of anti-sigma-E factor RseA.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001912361 – 848ATP-dependent Clp protease ATP-binding subunit ClpC1Add BLAST848

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P9WPC9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-61228N

Protein interaction database and analysis system

More...IntActi		P9WPC9, 3 interactors

STRING: functional protein association networks

More...STRINGi		83332.Rv3596c

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P9WPC9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1848
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		P9WPC9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P9WPC9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 144Clp RPROSITE-ProRule annotationAdd BLAST143
Domaini425 – 460UVRPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5 – 70Repeat 1PROSITE-ProRule annotationAdd BLAST66
Regioni80 – 144Repeat 2PROSITE-ProRule annotationAdd BLAST65
Regioni171 – 418IAdd BLAST248
Regioni479 – 670IIAdd BLAST192
Regioni821 – 848DisorderedSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ClpA/ClpB family. ClpC subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0542, Bacteria

Identification of Orthologs from Complete Genome Data

More...OMAi		ERMKAVM

Database for complete collections of gene phylogenies

More...PhylomeDBi		P9WPC9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1780.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR019489, Clp_ATPase_C
IPR036628, Clp_N_dom_sf
IPR004176, Clp_R_dom
IPR001270, ClpA/B
IPR018368, ClpA/B_CS1
IPR041546, ClpA/ClpB_AAA_lid
IPR027417, P-loop_NTPase
IPR001943, UVR_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00004, AAA, 1 hit
PF07724, AAA_2, 1 hit
PF17871, AAA_lid_9, 1 hit
PF02861, Clp_N, 2 hits
PF10431, ClpB_D2-small, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00300, CLPPROTEASEA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits
SM01086, ClpB_D2-small, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits
SSF81923, SSF81923, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51903, CLP_R, 1 hit
PS00870, CLPAB_1, 1 hit
PS50151, UVR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WPC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFERFTDRAR RVVVLAQEEA RMLNHNYIGT EHILLGLIHE GEGVAAKSLE 
        60         70         80         90        100
SLGISLEGVR SQVEEIIGQG QQAPSGHIPF TPRAKKVLEL SLREALQLGH 
       110        120        130        140        150
NYIGTEHILL GLIREGEGVA AQVLVKLGAE LTRVRQQVIQ LLSGYQGKEA 
       160        170        180        190        200
AEAGTGGRGG ESGSPSTSLV LDQFGRNLTA AAMEGKLDPV IGREKEIERV 
       210        220        230        240        250
MQVLSRRTKN NPVLIGEPGV GKTAVVEGLA QAIVHGEVPE TLKDKQLYTL 
       260        270        280        290        300
DLGSLVAGSR YRGDFEERLK KVLKEINTRG DIILFIDELH TLVGAGAAEG 
       310        320        330        340        350
AIDAASILKP KLARGELQTI GATTLDEYRK YIEKDAALER RFQPVQVGEP 
       360        370        380        390        400
TVEHTIEILK GLRDRYEAHH RVSITDAAMV AAATLADRYI NDRFLPDKAI 
       410        420        430        440        450
DLIDEAGARM RIRRMTAPPD LREFDEKIAE ARREKESAID AQDFEKAASL 
       460        470        480        490        500
RDREKTLVAQ RAEREKQWRS GDLDVVAEVD DEQIAEVLGN WTGIPVFKLT 
       510        520        530        540        550
EAETTRLLRM EEELHKRIIG QEDAVKAVSK AIRRTRAGLK DPKRPSGSFI 
       560        570        580        590        600
FAGPSGVGKT ELSKALANFL FGDDDALIQI DMGEFHDRFT ASRLFGAPPG 
       610        620        630        640        650
YVGYEEGGQL TEKVRRKPFS VVLFDEIEKA HQEIYNSLLQ VLEDGRLTDG 
       660        670        680        690        700
QGRTVDFKNT VLIFTSNLGT SDISKPVGLG FSKGGGENDY ERMKQKVNDE 
       710        720        730        740        750
LKKHFRPEFL NRIDDIIVFH QLTREEIIRM VDLMISRVAG QLKSKDMALV 
       760        770        780        790        800
LTDAAKALLA KRGFDPVLGA RPLRRTIQRE IEDQLSEKIL FEEVGPGQVV 
       810        820        830        840 
TVDVDNWDGE GPGEDAVFTF TGTRKPPAEP DLAKAGAHSA GGPEPAAR
Length:848
Mass (Da):93,552
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D536FBDA183CD94
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46419.1

Protein sequence database of the Protein Information Resource

More...PIRi		E70954

NCBI Reference Sequences

More...RefSeqi		WP_003419511.1, NZ_NVQJ01000056.1
YP_177995.1, NC_000962.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		45427583
885104

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mtu:Rv3596c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46419.1
PIRiE70954
RefSeqiWP_003419511.1, NZ_NVQJ01000056.1
YP_177995.1, NC_000962.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WDBX-ray1.37A1-145[»]
3WDCX-ray1.18A1-145[»]
3WDDX-ray1.18A3-145[»]
3WDEX-ray1.44A1-145[»]
6CN8X-ray1.40A1-145[»]
6PBAX-ray1.77A1-145[»]
6PBQX-ray1.60A1-145[»]
6PBSX-ray2.50A/B/C/G/I/K/M/O/T/W/Y/e1-145[»]
6UCRX-ray2.30A1-145[»]
SASBDBiP9WPC9
SMRiP9WPC9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-61228N
IntActiP9WPC9, 3 interactors
STRINGi83332.Rv3596c

Chemistry databases

BindingDBiP9WPC9

Proteomic databases

PaxDbiP9WPC9

Genome annotation databases

GeneIDi45427583
885104
KEGGimtu:Rv3596c

Organism-specific databases

TubercuListiRv3596c

Phylogenomic databases

eggNOGiCOG0542, Bacteria
OMAiERMKAVM
PhylomeDBiP9WPC9

Enzyme and pathway databases

BRENDAi3.4.21.92, 3445

Family and domain databases

Gene3Di1.10.1780.10, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR019489, Clp_ATPase_C
IPR036628, Clp_N_dom_sf
IPR004176, Clp_R_dom
IPR001270, ClpA/B
IPR018368, ClpA/B_CS1
IPR041546, ClpA/ClpB_AAA_lid
IPR027417, P-loop_NTPase
IPR001943, UVR_dom
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF07724, AAA_2, 1 hit
PF17871, AAA_lid_9, 1 hit
PF02861, Clp_N, 2 hits
PF10431, ClpB_D2-small, 1 hit
PRINTSiPR00300, CLPPROTEASEA
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SM01086, ClpB_D2-small, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF81923, SSF81923, 1 hit
PROSITEiView protein in PROSITE
PS51903, CLP_R, 1 hit
PS00870, CLPAB_1, 1 hit
PS50151, UVR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLPC1_MYCTU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WPC9
Secondary accession number(s): L0TD96, O06286, P0A522
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 2, 2021
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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