UniProtKB - P9WP99 (PDUO_MYCTU)
Protein
Corrinoid adenosyltransferase
Gene
Rv1314c
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalytic activityi
- 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphateEC:2.5.1.17
- 2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphateEC:2.5.1.17
: adenosylcobalamin biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.Proteins known to be involved in the 7 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Corrinoid adenosyltransferase (Rv1314c)
- no protein annotated in this organism
- no protein annotated in this organism
- no protein annotated in this organism
- Adenosylcobinamide kinase (cobU)
- Adenosylcobinamide-GDP ribazoletransferase (cobS)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 28 | ATPBy similarity | 1 | |
Binding sitei | 163 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPBy similarity | 9 | |
Nucleotide bindingi | 137 – 142 | ATPBy similarity | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: GO_Central
GO - Biological processi
- cobalamin biosynthetic process Source: UniProtKB-UniPathway
- porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Cobalamin biosynthesis, Porphyrin biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00148;UER00233 |
Names & Taxonomyi
Protein namesi | Recommended name: Corrinoid adenosyltransferase (EC:2.5.1.17)Alternative name(s): Cob(II)alamin adenosyltransferase Cob(II)yrinic acid a,c-diamide adenosyltransferase Cobinamide/cobalamin adenosyltransferase |
Gene namesi | Ordered Locus Names:Rv1314c ORF Names:MTCY373.34c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1314c |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000103798 | 1 – 193 | Corrinoid adenosyltransferaseAdd BLAST | 193 |
Proteomic databases
PaxDbi | P9WP99 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WP99 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the Cob(I)alamin adenosyltransferase family.Curated
Phylogenomic databases
eggNOGi | COG2096, Bacteria |
OMAi | HQACTVV |
PhylomeDBi | P9WP99 |
Family and domain databases
Gene3Di | 1.20.1200.10, 1 hit |
InterProi | View protein in InterPro IPR016030, CblAdoTrfase-like IPR036451, CblAdoTrfase-like_sf IPR029499, PduO-typ |
PANTHERi | PTHR12213, PTHR12213, 1 hit |
Pfami | View protein in Pfam PF01923, Cob_adeno_trans, 1 hit |
SUPFAMi | SSF89028, SSF89028, 1 hit |
TIGRFAMsi | TIGR00636, PduO_Nterm, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WP99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVHLTRIYT RTGDDGTTGL SDMSRVAKTD ARLVAYADCD EANAAIGAAL
60 70 80 90 100
ALGHPDTQIT DVLRQIQNDL FDAGADLSTP IVENPKHPPL RIAQSYIDRL
110 120 130 140 150
EGWCDAYNAG LPALKSFVLP GGSPLSALLH VARTVVRRAE RSAWAAVDAH
160 170 180 190
PEGVSVLPAK YLNRLSDLLF ILSRVANPDG DVLWRPGGDR TAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44071.1 |
PIRi | F70775 |
RefSeqi | NP_215830.1, NC_000962.3 WP_003406839.1, NZ_NVQJ01000059.1 |
Genome annotation databases
GeneIDi | 45425287 886925 |
KEGGi | mtu:Rv1314c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44071.1 |
PIRi | F70775 |
RefSeqi | NP_215830.1, NC_000962.3 WP_003406839.1, NZ_NVQJ01000059.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2G2D | X-ray | 2.00 | A | 1-193 | [»] | |
SMRi | P9WP99 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1314c |
Proteomic databases
PaxDbi | P9WP99 |
Genome annotation databases
GeneIDi | 45425287 886925 |
KEGGi | mtu:Rv1314c |
Organism-specific databases
TubercuListi | Rv1314c |
Phylogenomic databases
eggNOGi | COG2096, Bacteria |
OMAi | HQACTVV |
PhylomeDBi | P9WP99 |
Enzyme and pathway databases
UniPathwayi | UPA00148;UER00233 |
Family and domain databases
Gene3Di | 1.20.1200.10, 1 hit |
InterProi | View protein in InterPro IPR016030, CblAdoTrfase-like IPR036451, CblAdoTrfase-like_sf IPR029499, PduO-typ |
PANTHERi | PTHR12213, PTHR12213, 1 hit |
Pfami | View protein in Pfam PF01923, Cob_adeno_trans, 1 hit |
SUPFAMi | SSF89028, SSF89028, 1 hit |
TIGRFAMsi | TIGR00636, PduO_Nterm, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDUO_MYCTU | |
Accessioni | P9WP99Primary (citable) accession number: P9WP99 Secondary accession number(s): L0T6A0, P64803, Q10622 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | April 7, 2021 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families