UniProtKB - P9WP89 (COBK_MYCTU)
Protein
Precorrin-6A reductase
Gene
cobK
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.By similarity
Catalytic activityi
- EC:1.3.1.54
: adenosylcobalamin biosynthesis Pathwayi
This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route).Proteins known to be involved in the 10 steps of the subpathway in this organism are:
- Cobalamin biosynthesis protein CobIJ (cobIJ)
- no protein annotated in this organism
- Cobalamin biosynthesis protein CobIJ (cobIJ)
- Precorrin-4 C(11)-methyltransferase (cobM)
- no protein annotated in this organism
- Precorrin-6A reductase (cobK)
- Precorrin-6Y C(5,15)-methyltransferase [decarboxylating] (cobL)
- Precorrin-8X methylmutase (cobH)
- Hydrogenobyrinate a,c-diamide synthase (cobB)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- precorrin-6A reductase activity Source: UniProtKB-EC
GO - Biological processi
- cobalamin biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Cobalamin biosynthesis |
Ligand | NADP |
Enzyme and pathway databases
UniPathwayi | UPA00148;UER00217 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cobK Ordered Locus Names:Rv2070c ORF Names:MTCY49.09c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2070c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000135919 | 1 – 244 | Precorrin-6A reductaseAdd BLAST | 244 |
Proteomic databases
PaxDbi | P9WP89 |
Family & Domainsi
Sequence similaritiesi
Belongs to the precorrin-6x reductase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | COG2099, Bacteria |
OMAi | THPYAAQ |
PhylomeDBi | P9WP89 |
Family and domain databases
InterProi | View protein in InterPro IPR003723, Precorrin-6x_reduct |
PANTHERi | PTHR36925, PTHR36925, 1 hit |
Pfami | View protein in Pfam PF02571, CbiJ, 1 hit |
TIGRFAMsi | TIGR00715, precor6x_red, 1 hit |
PROSITEi | View protein in PROSITE PS51014, COBK_CBIJ, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WP89-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRVLLLGGT AEGRALAKEL HPHVEIVSSL AGRVPNPALP IGPVRIGGFG
60 70 80 90 100
GVEGLRGWLR EERIDAVVDA THPFAVTITA HAAQVCGELG LPYLVLARPP
110 120 130 140 150
WDPGTAIIAV SDIEAADVVA EQGYSRVFLT TGRSGIAAFA NSDAWFLIRV
160 170 180 190 200
VTAPDGTALP RRHKLVLSRG PYGYHDEFAL LREQRIDALV TKNSGGKMTR
210 220 230 240
AKLDAAAALG ISVVMIARPL LPAGVAAVDS VHRAAMWVAG LPSR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44844.1 |
PIRi | A70765 |
RefSeqi | NP_216586.1, NC_000962.3 WP_003900455.1, NZ_NVQJ01000047.1 |
Genome annotation databases
EnsemblBacteriai | CCP44844; CCP44844; Rv2070c |
GeneIDi | 887566 |
KEGGi | mtu:Rv2070c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44844.1 |
PIRi | A70765 |
RefSeqi | NP_216586.1, NC_000962.3 WP_003900455.1, NZ_NVQJ01000047.1 |
3D structure databases
SMRi | P9WP89 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2070c |
Proteomic databases
PaxDbi | P9WP89 |
Genome annotation databases
EnsemblBacteriai | CCP44844; CCP44844; Rv2070c |
GeneIDi | 887566 |
KEGGi | mtu:Rv2070c |
Organism-specific databases
TubercuListi | Rv2070c |
Phylogenomic databases
eggNOGi | COG2099, Bacteria |
OMAi | THPYAAQ |
PhylomeDBi | P9WP89 |
Enzyme and pathway databases
UniPathwayi | UPA00148;UER00217 |
Family and domain databases
InterProi | View protein in InterPro IPR003723, Precorrin-6x_reduct |
PANTHERi | PTHR36925, PTHR36925, 1 hit |
Pfami | View protein in Pfam PF02571, CbiJ, 1 hit |
TIGRFAMsi | TIGR00715, precor6x_red, 1 hit |
PROSITEi | View protein in PROSITE PS51014, COBK_CBIJ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COBK_MYCTU | |
Accessioni | P9WP89Primary (citable) accession number: P9WP89 Secondary accession number(s): L0TBE4, Q10680 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 10, 2021 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families