UniProtKB - P9WP85 (COBT_MYCTU)
Protein
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Gene
cobT
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).By similarity
Catalytic activityi
- 5,6-dimethylbenzimidazole + nicotinate β-D-ribonucleotide = α-ribazole 5'-phosphate + H+ + nicotinateEC:2.4.2.21
: alpha-ribazole biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
- Bifunctional protein Rv2228c (Rv2228c)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 314 | Proton acceptorBy similarity | 1 |
GO - Molecular functioni
- nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- cobalamin biosynthetic process Source: UniProtKB-KW
- nucleoside biosynthetic process Source: InterPro
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Cobalamin biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00061;UER00516 |
Names & Taxonomyi
Protein namesi | Recommended name: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC:2.4.2.21)Short name: NN:DBI PRT Alternative name(s): N(1)-alpha-phosphoribosyltransferase |
Gene namesi | Name:cobT Ordered Locus Names:Rv2207 ORF Names:MTCY190.18 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2207 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000167056 | 1 – 361 | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST | 361 |
Proteomic databases
PaxDbi | P9WP85 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CobT family.Curated
Phylogenomic databases
eggNOGi | COG2038, Bacteria |
OMAi | AIWYAGW |
PhylomeDBi | P9WP85 |
Family and domain databases
CDDi | cd02439, DMB-PRT_CobT, 1 hit |
Gene3Di | 1.10.1610.10, 1 hit 3.40.50.10210, 1 hit |
HAMAPi | MF_00230, CobT, 1 hit |
InterProi | View protein in InterPro IPR003200, Nict_dMeBzImd_PRibTrfase-like IPR023195, Nict_dMeBzImd_PRibTrfase_N IPR017846, Nict_dMeBzImd_PRibTrfase_pro IPR036087, Nict_dMeBzImd_PRibTrfase_sf |
Pfami | View protein in Pfam PF02277, DBI_PRT, 1 hit |
SUPFAMi | SSF52733, SSF52733, 1 hit |
TIGRFAMsi | TIGR03160, cobT_DBIPRT, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WP85-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIGFAPVSTP DAAAEAAARA RQDSLTKPRG ALGSLEDLSV WVASCQQRCP
60 70 80 90 100
PRQFERARVV VFAGDHGVAR SGVSAYPPEV TAQMVANIDA GGAAINALAD
110 120 130 140 150
VAGATVRVAD LAVDADPLSE RIGAHKVRRG SGNIATEDAL TNDETAAAIT
160 170 180 190 200
AGQQIADEEV DAGADLLIAG DMGIGNTTAA AVLVAALTDA EPVAVVGFGT
210 220 230 240 250
GIDDAGWARK TAAVRDALFR VRPVLPDPVG LLRCAGGADL AAIAGFCAQA
260 270 280 290 300
AVRRTPLLLD GVAVTAAALV AERLAPGAHR WWQAGHRSSE PGHGLALAAL
310 320 330 340 350
GLDPIVDLHM RLGEGTGAAV ALMVLRAAVA ALSSMATFTE AGVSTRSVDG
360
VDRTAPPAVS P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44984.1 |
PIRi | H70785 |
RefSeqi | NP_216723.1, NC_000962.3 WP_003411429.1, NZ_NVQJ01000008.1 |
Genome annotation databases
EnsemblBacteriai | CCP44984; CCP44984; Rv2207 |
GeneIDi | 45426183 887781 |
KEGGi | mtu:Rv2207 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44984.1 |
PIRi | H70785 |
RefSeqi | NP_216723.1, NC_000962.3 WP_003411429.1, NZ_NVQJ01000008.1 |
3D structure databases
SMRi | P9WP85 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2207 |
Proteomic databases
PaxDbi | P9WP85 |
Genome annotation databases
EnsemblBacteriai | CCP44984; CCP44984; Rv2207 |
GeneIDi | 45426183 887781 |
KEGGi | mtu:Rv2207 |
Organism-specific databases
TubercuListi | Rv2207 |
Phylogenomic databases
eggNOGi | COG2038, Bacteria |
OMAi | AIWYAGW |
PhylomeDBi | P9WP85 |
Enzyme and pathway databases
UniPathwayi | UPA00061;UER00516 |
Family and domain databases
CDDi | cd02439, DMB-PRT_CobT, 1 hit |
Gene3Di | 1.10.1610.10, 1 hit 3.40.50.10210, 1 hit |
HAMAPi | MF_00230, CobT, 1 hit |
InterProi | View protein in InterPro IPR003200, Nict_dMeBzImd_PRibTrfase-like IPR023195, Nict_dMeBzImd_PRibTrfase_N IPR017846, Nict_dMeBzImd_PRibTrfase_pro IPR036087, Nict_dMeBzImd_PRibTrfase_sf |
Pfami | View protein in Pfam PF02277, DBI_PRT, 1 hit |
SUPFAMi | SSF52733, SSF52733, 1 hit |
TIGRFAMsi | TIGR03160, cobT_DBIPRT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COBT_MYCTU | |
Accessioni | P9WP85Primary (citable) accession number: P9WP85 Secondary accession number(s): L0T8X8, P63841, Q10396 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 10, 2021 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families