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UniProtKB - P9WNY4 (MMSB_MYCTO)
Protein
Probable 3-hydroxyisobutyrate dehydrogenase
Gene
mmsB
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Catalytic activityi
- EC:1.1.1.31
: L-valine degradation Pathwayi
This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 93 | NADBy similarity | 1 | |
Active sitei | 168 | By similarity | 1 | |
Binding sitei | 243 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 3 – 31 | NADBy similarityAdd BLAST | 29 |
GO - Molecular functioni
- 3-hydroxyisobutyrate dehydrogenase activity Source: UniProtKB-EC
- NAD binding Source: InterPro
- NADP binding Source: InterPro
GO - Biological processi
- valine catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Branched-chain amino acid catabolism |
Ligand | NAD |
Enzyme and pathway databases
UniPathwayi | UPA00362 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mmsB Ordered Locus Names:MT0775 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000427046 | 1 – 294 | Probable 3-hydroxyisobutyrate dehydrogenaseAdd BLAST | 294 |
Family & Domainsi
Sequence similaritiesi
Belongs to the HIBADH-related family.Curated
Phylogenomic databases
HOGENOMi | CLU_035117_6_0_11 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR002204, 3-OH-isobutyrate_DH-rel_CS IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006115, 6PGDH_NADP-bd IPR011548, HIBADH IPR015815, HIBADH-related IPR036291, NAD(P)-bd_dom_sf IPR029154, NADP-bd |
Pfami | View protein in Pfam PF14833, NAD_binding_11, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000103, HIBADH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR01692, HIBADH, 1 hit |
PROSITEi | View protein in PROSITE PS00895, 3_HYDROXYISOBUT_DH, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WNY4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTIAFLGLG NMGAPMSANL VGAGHVVRGF DPAPTAASGA AAHGVAVFRS
60 70 80 90 100
APEAVAEADV VITMLPTGEV VRRCYTDVLA AARPATLFID SSTISVTDAR
110 120 130 140 150
EVHALAESHG MLQLDAPVSG GVKGAAAATL AFMVGGDEST LRRARPVLEP
160 170 180 190 200
MAGKIIHCGA AGAGQAAKVC NNMVLAVQQI AIAEAFVLAE KLGLSAQSLF
210 220 230 240 250
DVITGATGNC WAVHTNCPVP GPVPTSPANN DFKPGFSTAL MNKDLGLAMD
260 270 280 290
AVAATGATAP LGSHAADIYA KFAADHADLD FSAVIHTLRA RADA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK45016.1 |
PIRi | B70825 |
RefSeqi | WP_003403844.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK45016; AAK45016; MT0775 |
GeneIDi | 45424715 |
KEGGi | mtc:MT0775 |
PATRICi | fig|83331.31.peg.833 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK45016.1 |
PIRi | B70825 |
RefSeqi | WP_003403844.1, NZ_KK341227.1 |
3D structure databases
SMRi | P9WNY4 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK45016; AAK45016; MT0775 |
GeneIDi | 45424715 |
KEGGi | mtc:MT0775 |
PATRICi | fig|83331.31.peg.833 |
Phylogenomic databases
HOGENOMi | CLU_035117_6_0_11 |
Enzyme and pathway databases
UniPathwayi | UPA00362 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR002204, 3-OH-isobutyrate_DH-rel_CS IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006115, 6PGDH_NADP-bd IPR011548, HIBADH IPR015815, HIBADH-related IPR036291, NAD(P)-bd_dom_sf IPR029154, NADP-bd |
Pfami | View protein in Pfam PF14833, NAD_binding_11, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000103, HIBADH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR01692, HIBADH, 1 hit |
PROSITEi | View protein in PROSITE PS00895, 3_HYDROXYISOBUT_DH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MMSB_MYCTO | |
Accessioni | P9WNY4Primary (citable) accession number: P9WNY4 Secondary accession number(s): L0T7L8, O53814, P63935 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 23, 2022 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families