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UniProtKB - P9WNY1 (ALDH_MYCTU)
Protein
Probable aldehyde dehydrogenase
Gene
Rv0458
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalytic activityi
- EC:1.2.1.3
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 263 | By similarity | 1 | |
Active sitei | 302 | By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 219 – 225 | NADBy similarity | 7 |
GO - Molecular functioni
- aldehyde dehydrogenase (NAD+) activity Source: UniProtKB-EC
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Source: UniProtKB-EC
GO - Biological processi
- suppression by symbiont of host immune response Source: MTBBASE
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Ordered Locus Names:Rv0458 ORF Names:MTV038.02 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0458 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000056449 | 2 – 507 | Probable aldehyde dehydrogenaseAdd BLAST | 506 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | P9WNY1 |
PTM databases
iPTMneti | P9WNY1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | COG1012, Bacteria |
OMAi | ILMGAWK |
PhylomeDBi | P9WNY1 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P9WNY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVFSRPGSA GALMSYESRY QNFIGGQWVA PVHGRYFENP TPVTGQPFCE
60 70 80 90 100
VPRSDAADID KALDAAHAAA PGWGKTAPAE RAAILNMIAD RIDKNAAALA
110 120 130 140 150
VAEVWDNGKP VREALAADIP LAVDHFRYFA AAIRAQEGAL SQIDEDTVAY
160 170 180 190 200
HFHEPLGVVG QIIPWNFPIL MAAWKLAPAL AAGNTAVLKP AEQTPASVLY
210 220 230 240 250
LMSLIGDLLP PGVVNVVNGF GAEAGKPLAS SDRIAKVAFT GETTTGRLIM
260 270 280 290 300
QYASHNLIPV TLELGGKSPN IFFADVLAAH DDFCDKALEG FTMFALNQGE
310 320 330 340 350
VCTCPSRSLI QADIYDEFLE LAAIRTKAVR QGDPLDTETM LGSQASNDQL
360 370 380 390 400
EKVLSYIEIG KQEGAVIIAG GERAELGGDL SGGYYMQPTI FTGTNNMRIF
410 420 430 440 450
KEEIFGPVVA VTSFTDYDDA IGIANDTLYG LGAGVWSRDG NTAYRAGRDI
460 470 480 490 500
QAGRVWVNCY HLYPAHAAFG GYKQSGIGRE GHQMMLQHYQ HTKNLLVSYS
DKALGFF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43191.1 |
PIRi | F70827 |
RefSeqi | NP_214972.1, NC_000962.3 WP_003402294.1, NZ_NVQJ01000002.1 |
Genome annotation databases
GeneIDi | 45424420 886306 |
KEGGi | mtu:Rv0458 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43191.1 |
PIRi | F70827 |
RefSeqi | NP_214972.1, NC_000962.3 WP_003402294.1, NZ_NVQJ01000002.1 |
3D structure databases
AlphaFoldDBi | P9WNY1 |
SMRi | P9WNY1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv0458 |
PTM databases
iPTMneti | P9WNY1 |
Proteomic databases
PaxDbi | P9WNY1 |
Protocols and materials databases
DNASUi | 886306 |
Genome annotation databases
GeneIDi | 45424420 886306 |
KEGGi | mtu:Rv0458 |
Organism-specific databases
TubercuListi | Rv0458 |
Phylogenomic databases
eggNOGi | COG1012, Bacteria |
OMAi | ILMGAWK |
PhylomeDBi | P9WNY1 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALDH_MYCTU | |
Accessioni | P9WNY1Primary (citable) accession number: P9WNY1 Secondary accession number(s): L0T3T1, O53743, P63937 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | May 25, 2022 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families