UniProtKB - P9WNQ5 (ECCD2_MYCTU)
Protein
ESX-2 secretion system protein eccD2
Gene
eccD2
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Miscellaneous
Was identified as a high-confidence drug target.
GO - Biological processi
- active evasion of host immune response Source: MTBBASE
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-8185-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: ESX-2 secretion system protein eccD2Alternative name(s): ESX conserved component D2 Type VII secretion system protein eccD2 Short name: T7SS protein eccD2 |
Gene namesi | Name:eccD2 Ordered Locus Names:Rv3887c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3887c |
Subcellular locationi
- Cell membrane Curated; Multi-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 135 – 155 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 170 – 190 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 222 – 242 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 248 – 268 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 281 – 301 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 364 – 384 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 389 – 409 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 418 – 438 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 449 – 469 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 487 – 507 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000393234 | 1 – 509 | ESX-2 secretion system protein eccD2Add BLAST | 509 |
Proteomic databases
PaxDbi | P9WNQ5 |
PRIDEi | P9WNQ5 |
Interactioni
Subunit structurei
Part of the ESX-2 / type VII secretion system (T7SS), which is composed of cytosolic and membrane components.
By similarityProtein-protein interaction databases
STRINGi | 83332.Rv3887c |
Family & Domainsi
Sequence similaritiesi
Belongs to the EccD/Snm4 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
OMAi | PTIALWV |
Family and domain databases
InterProi | View protein in InterPro IPR006707 T7SS_EccD IPR024962 YukD-like |
Pfami | View protein in Pfam PF08817 YukD, 1 hit |
TIGRFAMsi | TIGR03920 T7SS_EccD, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WNQ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAPHKVAFP ARCAVNICYD KHLCSQVFPA GIPVEGFFEG MVELFDADLK
60 70 80 90 100
RKGFDGVALP AGSYELHKIN GVRLDINKSL DELGVQDGDT LVLVPRVAGE
110 120 130 140 150
SFEPQYESLS TGLAAMGKWL GRDGGDRMFA PVTSLTAAHT AMAIIAMAVG
160 170 180 190 200
VVLALTLRTR TITDSPVPAA MAGGIGVLLV IGALVVWWGW RERRDLFSGF
210 220 230 240 250
GWLAVVLLAV AAACAPPGAL GAAHALIGLV VVVLGAITIG VATRKRWQTA
260 270 280 290 300
VVTAVVTVCG ILAAVAAVRM FRPVSMQVLA ICVLVGLLVL IRMTPTVALW
310 320 330 340 350
VARVRPPHFG SITGRDLFAR RAGMPVDTVA PVSEADADDE DNELTDITAR
360 370 380 390 400
GTAIAASARL VNAVQVGMCV GVSLVLPAAV WGVLTPRQPW AWLALLVAGL
410 420 430 440 450
TVGLFITQGR GFAAKYQAVA LVCGASAAVC AGVLKYALDT PKGVQTGLLW
460 470 480 490 500
PAIFVAAFAA LGLAVALVVP ATRFRPIIRL TVEWLEVLAM IALLPAAAAL
GGLFAWLRH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46716.1 |
PIRi | H70597 |
RefSeqi | NP_218404.1, NC_000962.3 WP_003900775.1, NZ_NVQJ01000005.1 |
Genome annotation databases
EnsemblBacteriai | CCP46716; CCP46716; Rv3887c |
GeneIDi | 886211 |
KEGGi | mtu:Rv3887c mtv:RVBD_3887c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46716.1 |
PIRi | H70597 |
RefSeqi | NP_218404.1, NC_000962.3 WP_003900775.1, NZ_NVQJ01000005.1 |
3D structure databases
SMRi | P9WNQ5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv3887c |
Proteomic databases
PaxDbi | P9WNQ5 |
PRIDEi | P9WNQ5 |
Genome annotation databases
EnsemblBacteriai | CCP46716; CCP46716; Rv3887c |
GeneIDi | 886211 |
KEGGi | mtu:Rv3887c mtv:RVBD_3887c |
Organism-specific databases
TubercuListi | Rv3887c |
Phylogenomic databases
OMAi | PTIALWV |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-8185-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR006707 T7SS_EccD IPR024962 YukD-like |
Pfami | View protein in Pfam PF08817 YukD, 1 hit |
TIGRFAMsi | TIGR03920 T7SS_EccD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ECCD2_MYCTU | |
Accessioni | P9WNQ5Primary (citable) accession number: P9WNQ5 Secondary accession number(s): L0TGW9, O05457, Q8VIR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | November 13, 2019 | |
This is version 24 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names