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UniProtKB - P9WNP6 (FADB2_MYCTO)
Protein
3-hydroxybutyryl-CoA dehydrogenase
Gene
fadB2
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Catalytic activityi
- EC:1.1.1.157By similarity
: butanoate metabolism Pathwayi
This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 143 | Important for catalytic activityBy similarity | 1 |
GO - Molecular functioni
- 3-hydroxybutyryl-CoA dehydrogenase activity Source: UniProtKB-EC
- NAD+ binding Source: InterPro
GO - Biological processi
- butyrate metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | NADP |
Enzyme and pathway databases
UniPathwayi | UPA00863 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-hydroxybutyryl-CoA dehydrogenase (EC:1.1.1.157By similarity)Alternative name(s): Beta-hydroxybutyryl-CoA dehydrogenase Short name: BHBD |
Gene namesi | Name:fadB2 Ordered Locus Names:MT0484 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000427090 | 1 – 286 | 3-hydroxybutyryl-CoA dehydrogenaseAdd BLAST | 286 |
Family & Domainsi
Sequence similaritiesi
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
Phylogenomic databases
HOGENOMi | CLU_009834_2_0_11 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR022694, 3-OHacyl-CoA_DH IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit |
PIRSFi | PIRSF000105, HCDH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WNP6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDAIQRVGV VGAGQMGSGI AEVSARAGVE VTVFEPAEAL ITAGRNRIVK
60 70 80 90 100
SLERAVSAGK VTERERDRAL GLLTFTTDLN DLSDRQLVIE AVVEDEAVKS
110 120 130 140 150
EIFAELDRVV TDPDAVLASN TSSIPIMKVA AATKQPQRVL GLHFFNPVPV
160 170 180 190 200
LPLVELVRTL VTDEAAAART EEFASTVLGK QVVRCSDRSG FVVNALLVPY
210 220 230 240 250
LLSAIRMVEA GFATVEDVDK AVVAGLSHPM GPLRLSDLVG LDTLKLIADK
260 270 280
MFEEFKEPHY GPPPLLLRMV EAGQLGKKSG RGFYTY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK44708.1 |
PIRi | H70828 |
RefSeqi | WP_003402318.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK44708; AAK44708; MT0484 |
GeneIDi | 45424430 |
KEGGi | mtc:MT0484 |
PATRICi | fig|83331.31.peg.514 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK44708.1 |
PIRi | H70828 |
RefSeqi | WP_003402318.1, NZ_KK341227.1 |
3D structure databases
SMRi | P9WNP6 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK44708; AAK44708; MT0484 |
GeneIDi | 45424430 |
KEGGi | mtc:MT0484 |
PATRICi | fig|83331.31.peg.514 |
Phylogenomic databases
HOGENOMi | CLU_009834_2_0_11 |
Enzyme and pathway databases
UniPathwayi | UPA00863 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR022694, 3-OHacyl-CoA_DH IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit |
PIRSFi | PIRSF000105, HCDH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FADB2_MYCTO | |
Accessioni | P9WNP6Primary (citable) accession number: P9WNP6 Secondary accession number(s): L0T3U3, O53753, Q7D9R6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | April 7, 2021 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families