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Entry version 31 (18 Sep 2019)
Sequence version 1 (16 Apr 2014)
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Protein

Probable arabinosyltransferase C

Gene

embC

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.

Miscellaneous

This is one of the targets of the anti-tuberculosis drug ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB]. EMB is a first-line drug used to treat tuberculosis. EMB inhibits the transfer of arabinogalactan into the cell wall.
Was identified as a high-confidence drug target.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • arabinosyltransferase activity Source: MTBBASE

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAntibiotic resistance, Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:G185E-8089-MONOMER
MTBH37RV:G185E-8089-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT53 Glycosyltransferase Family 53

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable arabinosyltransferase C (EC:2.4.2.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:embC
Ordered Locus Names:Rv3793
ORF Names:MTCY13D12.27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv3793

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 50HelicalSequence analysisAdd BLAST23
Transmembranei232 – 251HelicalSequence analysisAdd BLAST20
Transmembranei264 – 286HelicalSequence analysisAdd BLAST23
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Transmembranei373 – 392HelicalSequence analysisAdd BLAST20
Transmembranei431 – 453HelicalSequence analysisAdd BLAST23
Transmembranei466 – 488HelicalSequence analysisAdd BLAST23
Transmembranei530 – 552HelicalSequence analysisAdd BLAST23
Transmembranei565 – 582HelicalSequence analysisAdd BLAST18
Transmembranei586 – 608HelicalSequence analysisAdd BLAST23
Transmembranei620 – 642HelicalSequence analysisAdd BLAST23
Transmembranei657 – 679HelicalSequence analysisAdd BLAST23
Transmembranei700 – 722HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00330 Ethambutol

DrugCentral

More...
DrugCentrali
P9WNL5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205731 – 1094Probable arabinosyltransferase CAdd BLAST1094

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WNL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Positively regulated by the transcriptional regulatory protein EmbR.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv3793

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11094
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P9WNL5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the emb family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105J1Z Bacteria
ENOG410XSQE LUCA

KEGG Orthology (KO)

More...
KOi
K11387

Identification of Orthologs from Complete Genome Data

More...
OMAi
RPFGHQN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P9WNL5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.610, 1 hit
2.60.120.940, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032731 Arabino_trans_C
IPR042486 Arabino_trans_C_2
IPR007680 Arabino_trans_central
IPR040920 Arabino_trans_N
IPR027451 EmbABC_dom1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14896 Arabino_trans_C, 1 hit
PF17689 Arabino_trans_N, 1 hit
PF04602 Arabinose_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WNL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATEAAPPRI AVRLPSTSVR DAGANYRIAR YVAVVAGLLG AVLAIATPLL
60 70 80 90 100
PVNQTTAQLN WPQNGTFASV EAPLIGYVAT DLNITVPCQA AAGLAGSQNT
110 120 130 140 150
GKTVLLSTVP KQAPKAVDRG LLLQRANDDL VLVVRNVPLV TAPLSQVLGP
160 170 180 190 200
TCQRLTFTAH ADRVAAEFVG LVQGPNAEHP GAPLRGERSG YDFRPQIVGV
210 220 230 240 250
FTDLAGPAPP GLSFSASVDT RYSSSPTPLK MAAMILGVAL TGAALVALHI
260 270 280 290 300
LDTADGMRHR RFLPARWWST GGLDTLVIAV LVWWHFVGAN TSDDGYILTM
310 320 330 340 350
ARVSEHAGYM ANYYRWFGTP EAPFGWYYDL LALWAHVSTA SIWMRLPTLA
360 370 380 390 400
MALTCWWVIS REVIPRLGHA VKTSRAAAWT AAGMFLAVWL PLDNGLRPEP
410 420 430 440 450
IIALGILLTW CSVERAVATS RLLPVAIACI IGALTLFSGP TGIASIGALL
460 470 480 490 500
VAIGPLRTIL HRRSRRFGVL PLVAPILAAA TVTAIPIFRD QTFAGEIQAN
510 520 530 540 550
LLKRAVGPSL KWFDEHIRYE RLFMASPDGS IARRFAVLAL VLALAVSVAM
560 570 580 590 600
SLRKGRIPGT AAGPSRRIIG ITIISFLAMM FTPTKWTHHF GVFAGLAGSL
610 620 630 640 650
GALAAVAVTG AAMRSRRNRT VFAAVVVFVL ALSFASVNGW WYVSNFGVPW
660 670 680 690 700
SNSFPKWRWS LTTALLELTV LVLLLAAWFH FVANGDGRRT ARPTRFRARL
710 720 730 740 750
AGIVQSPLAI ATWLLVLFEV VSLTQAMISQ YPAWSVGRSN LQALAGKTCG
760 770 780 790 800
LAEDVLVELD PNAGMLAPVT APLADALGAG LSEAFTPNGI PADVTADPVM
810 820 830 840 850
ERPGDRSFLN DDGLITGSEP GTEGGTTAAP GINGSRARLP YNLDPARTPV
860 870 880 890 900
LGSWRAGVQV PAMLRSGWYR LPTNEQRDRA PLLVVTAAGR FDSREVRLQW
910 920 930 940 950
ATDEQAAAGH HGGSMEFADV GAAPAWRNLR APLSAIPSTA TQVRLVADDQ
960 970 980 990 1000
DLAPQHWIAL TPPRIPRVRT LQNVVGAADP VFLDWLVGLA FPCQRPFGHQ
1010 1020 1030 1040 1050
YGVDETPKWR ILPDRFGAEA NSPVMDHNGG GPLGITELLM RATTVASYLK
1060 1070 1080 1090
DDWFRDWGAL QRLTPYYPDA QPADLNLGTV TRSGLWSPAP LRRG
Length:1,094
Mass (Da):117,490
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF8190BE0A1EA05E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti394N → D Resistance to EMB. 1 Publication1
Natural varianti738R → Q Resistance to EMB. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U68480 Genomic DNA Translation: AAC45279.1
AL123456 Genomic DNA Translation: CCP46622.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E70697

NCBI Reference Sequences

More...
RefSeqi
NP_218310.1, NC_000962.3
WP_003901726.1, NZ_NVQJ01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP46622; CCP46622; Rv3793

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
886112

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv3793
mtv:RVBD_3793

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68480 Genomic DNA Translation: AAC45279.1
AL123456 Genomic DNA Translation: CCP46622.1
PIRiE70697
RefSeqiNP_218310.1, NC_000962.3
WP_003901726.1, NZ_NVQJ01000009.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PTYX-ray2.00A719-1094[»]
SMRiP9WNL5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3793

Chemistry databases

DrugBankiDB00330 Ethambutol
DrugCentraliP9WNL5

Protein family/group databases

CAZyiGT53 Glycosyltransferase Family 53

Proteomic databases

PaxDbiP9WNL5

Genome annotation databases

EnsemblBacteriaiCCP46622; CCP46622; Rv3793
GeneIDi886112
KEGGimtu:Rv3793
mtv:RVBD_3793

Organism-specific databases

TubercuListiRv3793

Phylogenomic databases

eggNOGiENOG4105J1Z Bacteria
ENOG410XSQE LUCA
KOiK11387
OMAiRPFGHQN
PhylomeDBiP9WNL5

Enzyme and pathway databases

BioCyciMetaCyc:G185E-8089-MONOMER
MTBH37RV:G185E-8089-MONOMER

Family and domain databases

Gene3Di2.60.120.610, 1 hit
2.60.120.940, 1 hit
InterProiView protein in InterPro
IPR032731 Arabino_trans_C
IPR042486 Arabino_trans_C_2
IPR007680 Arabino_trans_central
IPR040920 Arabino_trans_N
IPR027451 EmbABC_dom1
PfamiView protein in Pfam
PF14896 Arabino_trans_C, 1 hit
PF17689 Arabino_trans_N, 1 hit
PF04602 Arabinose_trans, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMBC_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WNL5
Secondary accession number(s): L0TF98, O08116, P72059
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 18, 2019
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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