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UniProtKB - P9WNF6 (MYMA_MYCTO)
Protein
Putative FAD-containing monooxygenase MymA
Gene
mymA
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH.
By similarityCofactori
FADBy similarityNote: Binds 1 FAD per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 15 | FADBy similarity | 1 | |
Binding sitei | 36 | FADBy similarity | 1 | |
Binding sitei | 45 | FADBy similarity | 1 | |
Binding sitei | 104 | FAD; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Sitei | 296 | Transition state stabilizerSequence analysis | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 56 – 57 | FADBy similarity | 2 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- N,N-dimethylaniline monooxygenase activity Source: InterPro
- NADP binding Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | FAD, Flavoprotein |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mymA Ordered Locus Names:MT3168 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000427135 | 1 – 495 | Putative FAD-containing monooxygenase MymAAdd BLAST | 495 |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAD-binding monooxygenase family.Curated
Phylogenomic databases
HOGENOMi | CLU_032067_2_0_11 |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR020946, Flavin_mOase-like |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
SUPFAMi | SSF51905, SSF51905, 2 hits |
i Sequence
Sequence statusi: Complete.
P9WNF6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNQHFDVLII GAGLSGIGTA CHVTAEFPDK TIALLERRER LGGTWDLFRY
60 70 80 90 100
PGVRSDSDMF TFGYKFRPWR DVKVLADGAS IRQYIADTAT EFGVDEKIHY
110 120 130 140 150
GLKVNTAEWS SRQCRWTVAG VHEATGETRT YTCDYLISCT GYYNYDAGYL
160 170 180 190 200
PDFPGVHRFG GRCVHPQHWP EDLDYSGKKV VVIGSGATAV TLVPAMAGSN
210 220 230 240 250
PGSAAHVTML QRSPSYIFSL PAVDKISEVL GRFLPDRWVY EFGRRRNIAI
260 270 280 290 300
QRKLYQACRR WPKLMRRLLL WEVRRRLGRS VDMSNFTPNY LPWDERLCAV
310 320 330 340 350
PNGDLFKTLA SGAASVVTDQ IETFTEKGIL CKSGREIEAD IIVTATGLNI
360 370 380 390 400
QMLGGMRLIV DGAEYQLPEK MTYKGVLLEN APNLAWIIGY TNASWTLKSD
410 420 430 440 450
IAGAYLCRLL RHMADNGYTV ATPRDAQDCA LDVGMFDQLN SGYVKRGQDI
460 470 480 490
MPRQGSKHPW RVLMHYEKDA KILLEDPIDD GVLHFAAAAQ DHAAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK47504.1 |
PIRi | G70852 |
RefSeqi | WP_003899906.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK47504; AAK47504; MT3168 |
KEGGi | mtc:MT3168 |
PATRICi | fig|83331.31.peg.3414 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK47504.1 |
PIRi | G70852 |
RefSeqi | WP_003899906.1, NZ_KK341227.1 |
3D structure databases
AlphaFoldDBi | P9WNF6 |
SMRi | P9WNF6 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK47504; AAK47504; MT3168 |
KEGGi | mtc:MT3168 |
PATRICi | fig|83331.31.peg.3414 |
Phylogenomic databases
HOGENOMi | CLU_032067_2_0_11 |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR020946, Flavin_mOase-like |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
SUPFAMi | SSF51905, SSF51905, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MYMA_MYCTO | |
Accessioni | P9WNF6Primary (citable) accession number: P9WNF6 Secondary accession number(s): F2GNY5 Q7D658 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | May 25, 2022 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |