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Protein

Ferritin BfrB

Gene

bfrB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex.1 Publication

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Iron 1PROSITE-ProRule annotation1
Metal bindingi55Iron 1PROSITE-ProRule annotation1
Metal bindingi55Iron 2PROSITE-ProRule annotation1
Metal bindingi58Iron 1PROSITE-ProRule annotation1
Metal bindingi99Iron 2PROSITE-ProRule annotation1
Metal bindingi132Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric iron binding Source: InterPro
  • ferroxidase activity Source: MTBBASE
  • iron ion binding Source: GO_Central

GO - Biological processi

  • intracellular sequestering of iron ion Source: MTBBASE
  • iron assimilation by chelation and transport Source: Reactome
  • iron ion transport Source: InterPro
  • response to hypoxia Source: MTBBASE
  • response to nitrosative stress Source: MTBBASE

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1222449 Mtb iron assimilation by chelation

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin BfrB (EC:1.16.3.1)
Alternative name(s):
Non-heme ferritin Ftn
Nox19
Gene namesi
Name:bfrB
Synonyms:ftn
Ordered Locus Names:Rv3841
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3841

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • extracellular region Source: MTBBASE
  • plasma membrane Source: MTBBASE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003929422 – 181Ferritin BfrBAdd BLAST180

Proteomic databases

PaxDbiP9WNE5

Expressioni

Inductioni

Induced by 1 mM reactive nitrogen intermediate sodium nitroprusside dihydrate (at protein level). Induced by exposure to 50 µM FeCl3. A possible member of the dormancy regulon. Induced in response to reduced oxygen tension (hypoxia), repressed by carbon monoxide (CO). It is hoped that this regulon will give insight into the latent, or dormant phase of infection.4 Publications

Interactioni

Subunit structurei

Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored.1 Publication

Protein-protein interaction databases

STRINGi83332.Rv3841

Structurei

Secondary structure

1181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 38Combined sources29
Helixi42 – 68Combined sources27
Helixi88 – 115Combined sources28
Helixi119 – 149Combined sources31
Helixi153 – 163Combined sources11

3D structure databases

ProteinModelPortaliP9WNE5
SMRiP9WNE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 150Ferritin-like diironPROSITE-ProRule annotationAdd BLAST146

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated

Phylogenomic databases

eggNOGiENOG4107YEV Bacteria
COG1528 LUCA
KOiK22336
OMAiCEDKGFE
PhylomeDBiP9WNE5

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P9WNE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYEGPKTK FHALMQEQIH NEFTAAQQYV AIAVYFDSED LPQLAKHFYS
60 70 80 90 100
QAVEERNHAM MLVQHLLDRD LRVEIPGVDT VRNQFDRPRE ALALALDQER
110 120 130 140 150
TVTDQVGRLT AVARDEGDFL GEQFMQWFLQ EQIEEVALMA TLVRVADRAG
160 170 180
ANLFELENFV AREVDVAPAA SGAPHAAGGR L
Length:181
Mass (Da):20,442
Last modified:April 16, 2014 - v1
Checksum:iC0F375669A292F55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102693 Genomic DNA Translation: AAF06357.1
AL123456 Genomic DNA Translation: CCP46670.1
PIRiF70653
RefSeqiNP_218358.1, NC_000962.3
WP_003420920.1, NZ_KK339374.1

Genome annotation databases

EnsemblBacteriaiCCP46670; CCP46670; Rv3841
GeneIDi886176
KEGGimtu:Rv3841

Similar proteinsi

Entry informationi

Entry nameiBFRB_MYCTU
AccessioniPrimary (citable) accession number: P9WNE5
Secondary accession number(s): L0TGW6
, P96237, Q7BS08, Q7D4R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: February 28, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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