UniProtKB - P9WND5 (LLDD_MYCTU)
Protein
Putative L-lactate dehydrogenase
Gene
lldD
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Miscellaneous
Was identified as a high-confidence drug target.
Catalytic activityi
Cofactori
FMNPROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 55 | SubstratePROSITE-ProRule annotation | 1 | |
Binding sitei | 137 | FMNPROSITE-ProRule annotation | 1 | |
Binding sitei | 159 | FMNPROSITE-ProRule annotation | 1 | |
Binding sitei | 161 | SubstratePROSITE-ProRule annotation | 1 | |
Binding sitei | 187 | FMNPROSITE-ProRule annotation | 1 | |
Binding sitei | 196 | SubstratePROSITE-ProRule annotation | 1 | |
Binding sitei | 277 | FMNPROSITE-ProRule annotation | 1 | |
Active sitei | 301 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Binding sitei | 304 | SubstratePROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 332 – 356 | FMNPROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- FMN binding Source: InterPro
- L-lactate dehydrogenase activity Source: GO_Central
GO - Biological processi
- lactate oxidation Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Flavoprotein, FMN |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:lldD Synonyms:lldD2 Ordered Locus Names:Rv1872c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1872c |
Subcellular locationi
GO - Cellular componenti
- cell wall Source: MTBBASE
- plasma membrane Source: MTBBASE
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000390893 | 1 – 414 | Putative L-lactate dehydrogenaseAdd BLAST | 414 |
Proteomic databases
PaxDbi | P9WND5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 406 | FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST | 378 |
Sequence similaritiesi
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | COG1304, Bacteria |
OMAi | RIWFRPQ |
PhylomeDBi | P9WND5 |
Family and domain databases
CDDi | cd02809, alpha_hydroxyacid_oxid_FMN, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012133, Alpha-hydoxy_acid_DH_FMN IPR000262, FMN-dep_DH IPR037396, FMN_HAD IPR008259, FMN_hydac_DH_AS |
Pfami | View protein in Pfam PF01070, FMN_dh, 1 hit |
PIRSFi | PIRSF000138, Al-hdrx_acd_dh, 1 hit |
PROSITEi | View protein in PROSITE PS00557, FMN_HYDROXY_ACID_DH_1, 1 hit PS51349, FMN_HYDROXY_ACID_DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WND5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVNRRVPRV RDLAPLLQFN RPQFDTSKRR LGAALTIQDL RRIAKRRTPR
60 70 80 90 100
AAFDYADGGA EDELSIARAR QGFRDIEFHP TILRDVTTVC AGWNVLGQPT
110 120 130 140 150
VLPFGIAPTG FTRLMHTEGE IAGARAAAAA GIPFSLSTLA TCAIEDLVIA
160 170 180 190 200
VPQGRKWFQL YMWRDRDRSM ALVRRVAAAG FDTMLVTVDV PVAGARLRDV
210 220 230 240 250
RNGMSIPPAL TLRTVLDAMG HPRWWFDLLT TEPLAFASLD RWPGTVGEYL
260 270 280 290 300
NTVFDPSLTF DDLAWIKSQW PGKLVVKGIQ TLDDARAVVD RGVDGIVLSN
310 320 330 340 350
HGGRQLDRAP VPFHLLPHVA RELGKHTEIL VDTGIMSGAD IVAAIALGAR
360 370 380 390 400
CTLIGRAYLY GLMAGGEAGV NRAIEILQTG VIRTMRLLGV TCLEELSPRH
410
VTQLRRLGPI GAPT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44638.1 |
PIRi | H70667 |
RefSeqi | NP_216388.1, NC_000962.3 WP_003899057.1, NZ_NVQJ01000013.1 |
Genome annotation databases
EnsemblBacteriai | CCP44638; CCP44638; Rv1872c |
GeneIDi | 885754 |
KEGGi | mtu:Rv1872c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44638.1 |
PIRi | H70667 |
RefSeqi | NP_216388.1, NC_000962.3 WP_003899057.1, NZ_NVQJ01000013.1 |
3D structure databases
SMRi | P9WND5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1872c |
Proteomic databases
PaxDbi | P9WND5 |
Genome annotation databases
EnsemblBacteriai | CCP44638; CCP44638; Rv1872c |
GeneIDi | 885754 |
KEGGi | mtu:Rv1872c |
Organism-specific databases
TubercuListi | Rv1872c |
Phylogenomic databases
eggNOGi | COG1304, Bacteria |
OMAi | RIWFRPQ |
PhylomeDBi | P9WND5 |
Family and domain databases
CDDi | cd02809, alpha_hydroxyacid_oxid_FMN, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012133, Alpha-hydoxy_acid_DH_FMN IPR000262, FMN-dep_DH IPR037396, FMN_HAD IPR008259, FMN_hydac_DH_AS |
Pfami | View protein in Pfam PF01070, FMN_dh, 1 hit |
PIRSFi | PIRSF000138, Al-hdrx_acd_dh, 1 hit |
PROSITEi | View protein in PROSITE PS00557, FMN_HYDROXY_ACID_DH_1, 1 hit PS51349, FMN_HYDROXY_ACID_DH_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LLDD_MYCTU | |
Accessioni | P9WND5Primary (citable) accession number: P9WND5 Secondary accession number(s): L0T848, P95143, Q7D7V5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 10, 2021 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families