Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 7,8-dihydroneopterin aldolase (LH57_19660), Dihydroneopterin aldolase (folB)
  4. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00077;UER00155

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Ordered Locus Names:Rv3606c
ORF Names:MTCY07H7B.16
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3606c

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682551 – 1882-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd BLAST188

Proteomic databases

PaxDbiP9WNC7
PRIDEiP9WNC7

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3606c

Structurei

3D structure databases

ProteinModelPortaliP9WNC7
SMRiP9WNC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiENOG4105K8U Bacteria
COG0801 LUCA
KOiK00950
OMAiKDERWGP
PhylomeDBiP9WNC7

Family and domain databases

CDDicd00483 HPPK, 1 hit
Gene3Di3.30.70.560, 1 hit
InterProiView protein in InterPro
IPR000550 Hppk
IPR035907 Hppk_sf
PfamiView protein in Pfam
PF01288 HPPK, 1 hit
SUPFAMiSSF55083 SSF55083, 1 hit
TIGRFAMsiTIGR01498 folK, 1 hit
PROSITEiView protein in PROSITE
PS00794 HPPK, 1 hit

Sequencei

Sequence statusi: Complete.

P9WNC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRVVLSVGS NLGDRLARLR SVADGLGDAL IAASPIYEAD PWGGVEQGQF
60 70 80 90 100
LNAVLIADDP TCEPREWLRR AQEFERAAGR VRGQRWGPRN LDVDLIACYQ
110 120 130 140 150
TSATEALVEV TARENHLTLP HPLAHLRAFV LIPWIAVDPT AQLTVAGCPR
160 170 180
PVTRLLAELE PADRDSVRLF RPSFDLNSRH PVSRAPES
Length:188
Mass (Da):20,732
Last modified:April 16, 2014 - v1
Checksum:iD14AE440760CDCF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46429.1
PIRiG70955
RefSeqiNP_218123.1, NC_000962.3
WP_003419536.1, NZ_KK339374.1

Genome annotation databases

EnsemblBacteriaiCCP46429; CCP46429; Rv3606c
GeneIDi885848
KEGGimtu:Rv3606c

Similar proteinsi

Entry informationi

Entry nameiHPPK_MYCTU
AccessioniPrimary (citable) accession number: P9WNC7
Secondary accession number(s): L0TDA6, O06276, P64143
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: May 23, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again