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Entry version 29 (18 Sep 2019)
Sequence version 1 (16 Apr 2014)
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Protein

ESX-3 secretion system protein EccC3

Gene

eccC3

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.2 Publications

Miscellaneous

Was identified as a high-confidence drug target.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi479 – 486ATPPROSITE-ProRule annotation8
Nucleotide bindingi829 – 836ATPPROSITE-ProRule annotation8
Nucleotide bindingi1107 – 1114ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-4407-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ESX-3 secretion system protein EccC3Curated
Alternative name(s):
ESX conserved component C3Curated
Type VII secretion system protein EccC3Curated
Short name:
T7SS protein EccC3Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eccC31 Publication
Ordered Locus Names:Rv0284
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv0284

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003934301 – 1330ESX-3 secretion system protein EccC3Add BLAST1330

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WNA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed by IdeR in the presence of iron and by Zur in the presence of zinc.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the ESX-3 / type VII secretion system (T7SS), which is composed of cytosolic and membrane components. The ESX-3 membrane complex is composed of EccB3, EccC3, EccD3 and EccE3.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv0284

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P9WNA9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini456 – 662FtsK 1PROSITE-ProRule annotationAdd BLAST207
Domaini811 – 1000FtsK 2PROSITE-ProRule annotationAdd BLAST190
Domaini1090 – 1280FtsK 3PROSITE-ProRule annotationAdd BLAST191

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1674 LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
DGIYDPP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P9WNA9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR023836 EccCa-like_Actinobacteria
IPR023837 EccCb-like_Actinobacteria
IPR002543 FtsK_dom
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01580 FtsK_SpoIIIE, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03924 T7SS_EccC_a, 1 hit
TIGR03925 T7SS_EccC_b, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50901 FTSK, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WNA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRLIFEARR RLAPPSSHQG TIIIEAPPEL PRVIPPSLLR RALPYLIGIL
60 70 80 90 100
IVGMIVALVA TGMRVISPQT LFFPFVLLLA ATALYRGNDK KMRTEEVDAE
110 120 130 140 150
RADYLRYLSV VRDNIRAQAA EQRASALWSH PDPTALASVP GSRRQWERDP
160 170 180 190 200
HDPDFLVLRA GRHTVPLATT LRVNDTADEI DLEPVSHSAL RSLLDTQRSI
210 220 230 240 250
GDVPTGIDLT KVSPITVLGE RAQVRAVLRA WIAQAVTWHD PTVLGVALAA
260 270 280 290 300
RDLEGRDWNW LKWLPHVDIP GRLDALGPAR NLSTDPDELI ALLGPVLADR
310 320 330 340 350
PAFTGQPTDA LRHLLIVVDD PDYDLGASPL AVGRAGVTVV HCSASAPHRE
360 370 380 390 400
QYSDPEKPIL RVAHGAIERW QTGGWQPYID AADQFSADEA AHLARRLSRW
410 420 430 440 450
DSNPTHAGLR SAATRGASFT TLLGIEDASR LDVPALWAPR RRDEELRVPI
460 470 480 490 500
GVTGTGEPLM FDLKDEAEGG MGPHGLMIGM TGSGKSQTLM SILLSLLTTH
510 520 530 540 550
SAERLIVIYA DFKGEAGADS FRDFPQVVAV ISNMAEKKSL ADRFADTLRG
560 570 580 590 600
EVARREMLLR EAGRKVQGSA FNSVLEYENA IAAGHSLPPI PTLFVVADEF
610 620 630 640 650
TLMLADHPEY AELFDYVARK GRSFRIHILF ASQTLDVGKI KDIDKNTAYR
660 670 680 690 700
IGLKVASPSV SRQIIGVEDA YHIESGKEHK GVGFLVPAPG ATPIRFRSTY
710 720 730 740 750
VDGIYEPPQT AKAVVVQSVP EPKLFTAAAV EPDPGTVIAD TDEQEPADPP
760 770 780 790 800
RKLIATIGEQ LARYGPRAPQ LWLPPLDETI PLSAALARAG VGPRQWRWPL
810 820 830 840 850
GEIDRPFEMR RDPLVFDARS SAGNMVIHGG PKSGKSTALQ TFILSAASLH
860 870 880 890 900
SPHEVSFYCL DYGGGQLRAL QDLAHVGSVA SALEPERIRR TFGELEQLLL
910 920 930 940 950
SRQQREVFRD RGANGSTPDD GFGEVFLVID NLYGFGRDNT DQFNTRNPLL
960 970 980 990 1000
ARVTELVNVG LAYGIHVIIT TPSWLEVPLA MRDGLGLRLE LRLHDARDSN
1010 1020 1030 1040 1050
VRVVGALRRP ADAVPHDQPG RGLTMAAEHF LFAAPELDAQ TNPVAAINAR
1060 1070 1080 1090 1100
YPGMAAPPVR LLPTNLAPHA VGELYRGPDQ LVIGQREEDL APVILDLAAN
1110 1120 1130 1140 1150
PLLMVFGDAR SGKTTLLRHI IRTVREHSTA DRVAFTVLDR RLHLVDEPLF
1160 1170 1180 1190 1200
PDNEYTANID RIIPAMLGLA NLIEARRPPA GMSAAELSRW TFAGHTHYLI
1210 1220 1230 1240 1250
IDDVDQVPDS PAMTGPYIGQ RPWTPLIGLL AQAGDLGLRV IVTGRATGSA
1260 1270 1280 1290 1300
HLLMTSPLLR RFNDLQATTL MLAGNPADSG KIRGERFARL PAGRAILLTD
1310 1320 1330
SDSPTYVQLI NPLVDAAAVS GETQQKGSQS
Length:1,330
Mass (Da):145,170
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7D09C3067EE751B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43014.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B70836

NCBI Reference Sequences

More...
RefSeqi
NP_214798.1, NC_000962.3
WP_003916637.1, NZ_NVQJ01000026.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP43014; CCP43014; Rv0284

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
886611

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv0284
mtv:RVBD_0284

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43014.1
PIRiB70836
RefSeqiNP_214798.1, NC_000962.3
WP_003916637.1, NZ_NVQJ01000026.1

3D structure databases

SMRiP9WNA9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0284

Proteomic databases

PaxDbiP9WNA9

Genome annotation databases

EnsemblBacteriaiCCP43014; CCP43014; Rv0284
GeneIDi886611
KEGGimtu:Rv0284
mtv:RVBD_0284

Organism-specific databases

TubercuListiRv0284

Phylogenomic databases

eggNOGiCOG1674 LUCA
OMAiDGIYDPP
PhylomeDBiP9WNA9

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4407-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR023836 EccCa-like_Actinobacteria
IPR023837 EccCb-like_Actinobacteria
IPR002543 FtsK_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01580 FtsK_SpoIIIE, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 3 hits
SUPFAMiSSF52540 SSF52540, 3 hits
TIGRFAMsiTIGR03924 T7SS_EccC_a, 1 hit
TIGR03925 T7SS_EccC_b, 1 hit
PROSITEiView protein in PROSITE
PS50901 FTSK, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECCC3_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WNA9
Secondary accession number(s): L0T4X3, O53689, Q7DA37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 18, 2019
This is version 29 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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